Investigated event: Influence on protein activity in presence of IL-6

Name Value
Compound OPB-31121
Investigated event Influence on protein activity in presence of IL-6
Experiment type Western Blot
Concentration 100.00 nM
Cell line SNU484
Organism Homo sapiens
Animal model
STAT protein p-STAT3 (Y705)
Other
Reference
OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer letters Mi-Jung Kim, Hyun-Jin Nam, Hwang-Phill Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang, 335, 1, 2013-07-10, 2013-02-10, 10.1016/j.canlet.2013.02.010 DOI: 10.1016/j.canlet.2013.02.010 PUBMED: 23402820 PMCID: 23402820