Investigated event: Influence on cytokine secretion in presence of TNF
| Name | Value |
|---|---|
| Compound | Tofacitinib (CP-690.550) |
| Investigated event | Influence on cytokine secretion in presence of TNF |
| Experiment type | ELISA |
| Concentration | 1000.00 nM |
| Cell line | FLS |
| Organism | Homo sapiens |
| Animal model | |
| STAT protein | |
| Other | IL8 |
Reference
The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Annals of the rheumatic diseases Sanna Rosengren, Maripat Corr, Gary S Firestein, David L Boyle, 71, 3, None, 2011-11-25, 10.1136/ard.2011.150284
DOI: 10.1136/ard.2011.150284
PUBMED: 22121136
PMCID: 22121136