Investigated event: Influence on Th17 differentiation
| Name | Value |
|---|---|
| Compound | Tofacitinib (CP-690.550) |
| Investigated event | Influence on Th17 differentiation |
| Experiment type | Intracellular staining |
| Concentration | 50.00 nM |
| Cell line | Naïve CD4+ T |
| Organism | Mus musculus |
| Animal model | c57BL/6 |
| STAT protein | |
| Other | IL-17A - Foxp3 |
Reference
Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation. Biochemical and biophysical research communications Hideyuki Yoshida, Akihiro Kimura, Tomohiro Fukaya, Takashi Sekiya, Rimpei Morita, Takashi Shichita, Hiromasa Inoue, Akihiko Yoshimura, 418, 2, 2012-02-10, 2012-01-09, 10.1016/j.bbrc.2011.12.156
DOI: 10.1016/j.bbrc.2011.12.156
PUBMED: 22252297
PMCID: 22252297