Name	Value
Compound	Tofacitinib (CP-690.550)
Investigated event	Influence on EAE development
Experiment type	Mean Clinical Score
Concentration	15.00 mg/kg/day
Cell line
Organism	Mus musculus
Animal model	DBA/1
STAT protein
Other

Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation. Biochemical and biophysical research communications Hideyuki Yoshida, Akihiro Kimura, Tomohiro Fukaya, Takashi Sekiya, Rimpei Morita, Takashi Shichita, Hiromasa Inoue, Akihiko Yoshimura, 418, 2, 2012-02-10, 2012-01-09, 10.1016/j.bbrc.2011.12.156 DOI: 10.1016/j.bbrc.2011.12.156 PUBMED: 22252297 PMCID: 22252297