Investigated event: Influence on protein activity in tumor tissue
| Name | Value |
|---|---|
| Compound | Ponatinib |
| Investigated event | Influence on protein activity in tumor tissue |
| Experiment type | Immunohistochemistry |
| Concentration | 10.00 mg/kg |
| Cell line | DLD-1 (xenograft) |
| Organism | Mus musculus |
| Animal model | BALB/c |
| STAT protein | p-STAT3 |
| Other |
Reference
Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth. Cancers Fiona H Tan, Tracy L Putoczki, Jieqiong Lou, Elizabeth Hinde, Frédéric Hollande, Julie Giraud, Stanley S Stylli, Lucia Paradiso, Hong-Jian Zhu, Oliver M Sieber, Rodney B Luwor, 10, 12, 2018-12-19, 2018-12-19, 10.3390/cancers10120526
DOI: 10.3390/cancers10120526
PUBMED: 30572654
PMCID: PMC6316865