S31-201/ NSC 74859

Name Value
Weight 365.363 g/mol
Zinc ID ZINC1621282
Smiles Cc1ccc(S(=O)(=O)OCC(=O)Nc2ccc(C(=O)O)c(O)c2)cc1
Molecular formula C16H15NO7S
Mode of inhibition Direct STAT SH2; Non-peptide small molecule
CAS 501919-59-1

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
S3I-201 ameliorates tubulointerstitial lesion of the kidneys in MRL/lpr mice. Biochemical and biophysical research communications Yunxia Du, Wei Zhang, Shuxia Liu, Xiaojuan Feng, Fan Gao, Qingjuan Liu, 503, 1, 2018-09-03, 2018-06-11, 10.1016/j.bbrc.2018.05.207 10.1016/j.bbrc.2018.05.207 29885836 29885836

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/S31-201.html
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/sigma/sml0330?lang=pl&region=PL
MERCK (Sigma Aldrich) https://www.merckmillipore.com/PL/pl/product/STAT3-Inhibitor-VI-S3I-201-CAS-501919-59-1-Calbiochem,EMD_BIO-573102
Abcam https://www.abcam.com/s3i-201-stat3-inhibitor-ab141434.html
BioVision https://www.biovision.com/stat3-inhibitor-i-s3i-201.html
Axon Medchem https://www.axonmedchem.com/product/2313
Santa Cruz Biotechnology https://www.scbt.com/p/stat3-inhibitor-vi-s3i-201-501919-59-1
Caymanchemical https://www.caymanchem.com/product/14336/s3i-201
Tocris https://www.tocris.com/products/nsc-74859_4655

Filter data

Compound S31-201/ NSC 74859
Experiment types Blood urea nitrogen level, Serum creatinie level, Urinary protein level, Western Blot
Concentrations 10.00
Cell lines blood, renal tissue
Organisms Mus musculus
Animal models MRL/MpJ, MRL/lpr
STAT proteins STAT1, STAT3, p-STAT1, p-STAT3
Other E-Cadherin, ICAM-1, MCP-1, α-SMA, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/lpr p-STAT1
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/MpJ p-STAT1
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/lpr STAT1
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/MpJ STAT1
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/lpr p-STAT3
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/MpJ p-STAT3
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/lpr STAT3
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/MpJ STAT3
S31-201/ NSC 74859 Serum creatinie level Influence on kidney finction 10.00 mg/kg blood Mus musculus MRL/lpr
S31-201/ NSC 74859 Serum creatinie level Influence on kidney finction 10.00 mg/kg blood Mus musculus MRL/MpJ
S31-201/ NSC 74859 Blood urea nitrogen level Influence on kidney finction 10.00 mg/kg blood Mus musculus MRL/lpr
S31-201/ NSC 74859 Blood urea nitrogen level Influence on kidney finction 10.00 mg/kg blood Mus musculus MRL/MpJ
S31-201/ NSC 74859 Urinary protein level Influence on kidney finction 10.00 mg/kg blood Mus musculus MRL/lpr
S31-201/ NSC 74859 Urinary protein level Influence on kidney finction 10.00 mg/kg renal tissue Mus musculus MRL/MpJ
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/lpr
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/MpJ
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/lpr
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/MpJ
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/lpr
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/MpJ
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/lpr
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/MpJ
S31-201/ NSC 74859 Western Blot Influence on protein activity 10.00 mg/kg renal tissue Mus musculus MRL/lpr