PY*LKTK

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT; Peptide
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Molecular cancer therapeutics James Turkson, Joon S Kim, Shumin Zhang, Jing Yuan, Mei Huang, Matthew Glenn, Eric Haura, Said Sebti, Andrew D Hamilton, Richard Jove, 3, 3, None, None, N/A N/A 15026546 15026546
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. The Journal of biological chemistry J Turkson, D Ryan, J S Kim, Y Zhang, Z Chen, E Haura, A Laudano, S Sebti, A D Hamilton, R Jove, 276, 48, 2001-11-30, 2001-09-28, 10.1074/jbc.M107527200 10.1074/jbc.M107527200 11579100 11579100

Filter data

Compound PY*LKTK
Experiment types EMSA, Trypan Blue staining , Western Blot
Concentrations 0.01, 0.03, 0.10, 0.30, 0.50, 0.80, 1.00, 100.00, 150.00, 200.00, 3.00, 30.00, 300.00, 50.00, 80.00
Cell lines MDA-MB-231, MDA-MB-453, NIH 3T3/v-Src, NIH3T3/v-Src
Organisms Homo sapiens, Mus musculus
Animal models
STAT proteins STAT1, STAT1:STAT1, STAT1:STAT3, STAT3:STAT3, STAT5:STAT5
Other

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
PY*LKTK EMSA Influence on protein-DNA binding 30.00 µM Homo sapiens STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 50.00 µM Homo sapiens STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 80.00 µM Homo sapiens STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 100.00 µM Homo sapiens STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 150.00 µM Homo sapiens STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 200.00 µM Homo sapiens STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 300.00 µM Homo sapiens STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 30.00 µM Homo sapiens STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 50.00 µM Homo sapiens STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 80.00 µM Homo sapiens STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 100.00 µM Homo sapiens STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 150.00 µM Homo sapiens STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 200.00 µM Homo sapiens STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 300.00 µM Homo sapiens STAT1:STAT1
PY*LKTK Trypan Blue staining Influence on cell proliferation 1.00 mM NIH3T3/v-Src Homo sapiens
PY*LKTK Trypan Blue staining Influence on cell proliferation 1.00 mM MDA-MB-231 Homo sapiens
PY*LKTK Trypan Blue staining Influence on cell proliferation 1.00 mM MDA-MB-453 Homo sapiens
PY*LKTK EMSA Infleunce on protein-DNA binding 0.01 mM NIH 3T3/v-Src Mus musculus STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.03 mM NIH 3T3/v-Src Mus musculus STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.10 mM NIH 3T3/v-Src Mus musculus STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.30 mM NIH 3T3/v-Src Mus musculus STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.50 mM NIH 3T3/v-Src Mus musculus STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 1.00 mM NIH 3T3/v-Src Mus musculus STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 3.00 mM NIH 3T3/v-Src Mus musculus STAT3:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.01 mM NIH 3T3/v-Src Mus musculus STAT1:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.03 mM NIH 3T3/v-Src Mus musculus STAT1:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.10 mM NIH 3T3/v-Src Mus musculus STAT1:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.30 mM NIH 3T3/v-Src Mus musculus STAT1:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.50 mM NIH 3T3/v-Src Mus musculus STAT1:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 1.00 mM NIH 3T3/v-Src Mus musculus STAT1:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 3.00 mM NIH 3T3/v-Src Mus musculus STAT1:STAT3
PY*LKTK EMSA Influence on protein-DNA binding 0.01 mM NIH 3T3/v-Src Mus musculus STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 0.03 mM NIH 3T3/v-Src Mus musculus STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 0.10 mM NIH 3T3/v-Src Mus musculus STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 0.30 mM NIH 3T3/v-Src Mus musculus STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 0.50 mM NIH 3T3/v-Src Mus musculus STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 1.00 mM NIH 3T3/v-Src Mus musculus STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 3.00 mM NIH 3T3/v-Src Mus musculus STAT1:STAT1
PY*LKTK EMSA Influence on protein-DNA binding 0.01 mM NIH 3T3/v-Src Mus musculus STAT5:STAT5
PY*LKTK EMSA Influence on protein-DNA binding 0.03 mM NIH 3T3/v-Src Mus musculus STAT5:STAT5
PY*LKTK EMSA Influence on protein-DNA binding 0.10 mM NIH 3T3/v-Src Mus musculus STAT5:STAT5
PY*LKTK EMSA Influence on protein-DNA binding 0.30 mM NIH 3T3/v-Src Mus musculus STAT5:STAT5
PY*LKTK EMSA Influence on protein-DNA binding 0.50 mM NIH 3T3/v-Src Mus musculus STAT5:STAT5
PY*LKTK EMSA Influence on protein-DNA binding 1.00 mM NIH 3T3/v-Src Mus musculus STAT5:STAT5
PY*LKTK EMSA Influence on protein-DNA binding 3.00 mM NIH 3T3/v-Src Mus musculus STAT5:STAT5
PY*LKTK Western Blot Influence on protein activity 0.10 mM NIH 3T3/v-Src Mus musculus STAT1
PY*LKTK Western Blot Influence on protein activity 0.30 mM NIH 3T3/v-Src Mus musculus STAT1
PY*LKTK Western Blot Influence on protein activity 0.50 mM NIH 3T3/v-Src Mus musculus STAT1
PY*LKTK Western Blot Influence on protein activity 0.80 mM NIH 3T3/v-Src Mus musculus STAT1