PG-S3-002

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics. Molecular cancer therapeutics Carolyn C Arpin, Stephen Mac, Yanlin Jiang, Huiwen Cheng, Michelle Grimard, Brent D G Page, Malgorzata M Kamocka, Sina Haftchenary, Han Su, Daniel P Ball, David A Rosa, Ping-Shan Lai, Rodolfo F Gómez-Biagi, Ahmed M Ali, Rahul Rana, Helmut Hanenberg, Kagan Kerman, Kyle C McElyea, George E Sandusky, Patrick T Gunning, Melissa L Fishel, 15, 5, None, 2016-02-12, 10.1158/1535-7163.MCT-15-0003 10.1158/1535-7163.MCT-15-0003 26873728 PMC4873422

Filter data

Compound PG-S3-002
Experiment types Fluorescence polarization competition assay , Surface Plasmon Resonance
Concentrations 0.01, 0.10, 10.00, 100.00, 1000.00
Cell lines
Organisms
Animal models
STAT proteins STAT3
Other

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
PG-S3-002 Fluorescence polarization competition assay Inhibitor interaction with protein 0.01 µM STAT3
PG-S3-002 Fluorescence polarization competition assay Inhibitor interaction with protein 0.10 µM STAT3
PG-S3-002 Fluorescence polarization competition assay Inhibitor interaction with protein 10.00 µM STAT3
PG-S3-002 Fluorescence polarization competition assay Inhibitor interaction with protein 100.00 µM STAT3
PG-S3-002 Fluorescence polarization competition assay Inhibitor interaction with protein 1000.00 µM STAT3
PG-S3-002 Surface Plasmon Resonance Inhibitor interaction with protein 0.01 µM STAT3
PG-S3-002 Surface Plasmon Resonance Inhibitor interaction with protein 0.10 µM STAT3
PG-S3-002 Surface Plasmon Resonance Inhibitor interaction with protein 10.00 µM STAT3
PG-S3-002 Surface Plasmon Resonance Inhibitor interaction with protein 100.00 µM STAT3
PG-S3-002 Surface Plasmon Resonance Inhibitor interaction with protein 1000.00 µM STAT3