Osmium (II) complex

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT SH2
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Antagonizing STAT5B dimerization with an osmium complex. Scientific reports Li-Juan Liu, Wanhe Wang, Tian-Shu Kang, Jia-Xin Liang, Chenfu Liu, Daniel W J Kwong, Vincent Kam Wai Wong, Dik-Lung Ma, Chung-Hang Leung, 6, None, 2016-11-17, 2016-11-17, 10.1038/srep36044 10.1038/srep36044 27853239 PMC5113070

Filter data

Compound Osmium (II) complex
Experiment types ELISA, Luciferse activity, MTT Assay , Western Blot
Concentrations 0.30, 1.00, 10.00, 3.00, N/A
Cell lines Caco-2, LO-2
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, STAT5A, STAT5B, STAT5B(cytoplasmic), STAT5B(nuclear), p-STAT1, p-STAT3, p-STAT5B
Other Anti-FLAG, Anti-GFP, GAPDH, GAPDH(cytoplasmic), Lamin B1(nuclear)

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Osmium (II) complex ELISA Influence on protein-DNA interaction 10.00 µM Caco-2 Homo sapiens STAT5A
Osmium (II) complex ELISA Influence on protein-DNA interaction 10.00 µM Caco-2 Homo sapiens STAT5B
Osmium (II) complex Luciferse activity Influence on protein translocation in presence of PRL 0.30 µM Caco-2 Homo sapiens STAT5B
Osmium (II) complex Luciferse activity Influence on protein translocation in presence of PRL 1.00 µM Caco-2 Homo sapiens STAT5B
Osmium (II) complex Luciferse activity Influence on protein translocation in presence of PRL 3.00 µM Caco-2 Homo sapiens STAT5B
Osmium (II) complex Luciferse activity Influence on protein translocation in presence of PRL 10.00 µM Caco-2 Homo sapiens STAT5B
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 1.00 µM Caco-2 Homo sapiens STAT5B(cytoplasmic)
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 3.00 µM Caco-2 Homo sapiens STAT5B(cytoplasmic)
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 10.00 µM Caco-2 Homo sapiens STAT5B(cytoplasmic)
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 1.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 3.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 10.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 1.00 µM Caco-2 Homo sapiens STAT5B(nuclear)
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 3.00 µM Caco-2 Homo sapiens STAT5B(nuclear)
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 10.00 µM Caco-2 Homo sapiens STAT5B(nuclear)
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 1.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 3.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein translocation in presence of PRL 10.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein-protein interaction in presence of PRL in cells co-transfected with p-STAT5B-GFP and p-STAT5B-Flag 1.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein-protein interaction in presence of PRL in cells co-transfected with p-STAT5B-GFP and p-STAT5B-Flag 3.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein-protein interaction in presence of PRL in cells co-transfected with p-STAT5B-GFP and p-STAT5B-Flag 10.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein-protein interaction in presence of PRL in cells co-transfected with p-STAT5B-GFP and p-STAT5B-Flag 1.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein-protein interaction in presence of PRL in cells co-transfected with p-STAT5B-GFP and p-STAT5B-Flag 3.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein-protein interaction in presence of PRL in cells co-transfected with p-STAT5B-GFP and p-STAT5B-Flag 10.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 1.00 µM Caco-2 Homo sapiens STAT5B
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 3.00 µM Caco-2 Homo sapiens STAT5B
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 10.00 µM Caco-2 Homo sapiens STAT5B
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 1.00 µM Caco-2 Homo sapiens p-STAT5B
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 3.00 µM Caco-2 Homo sapiens p-STAT5B
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 10.00 µM Caco-2 Homo sapiens p-STAT5B
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 1.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 3.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 10.00 µM Caco-2 Homo sapiens
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 1.00 µM Caco-2 Homo sapiens p-STAT1
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 3.00 µM Caco-2 Homo sapiens p-STAT1
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 10.00 µM Caco-2 Homo sapiens p-STAT1
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 1.00 µM Caco-2 Homo sapiens STAT1
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 3.00 µM Caco-2 Homo sapiens STAT1
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 10.00 µM Caco-2 Homo sapiens STAT1
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 1.00 µM Caco-2 Homo sapiens p-STAT3
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 3.00 µM Caco-2 Homo sapiens p-STAT3
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 10.00 µM Caco-2 Homo sapiens p-STAT3
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 1.00 µM Caco-2 Homo sapiens STAT3
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 3.00 µM Caco-2 Homo sapiens STAT3
Osmium (II) complex Western Blot Influence on protein activity in presence of PRL 10.00 µM Caco-2 Homo sapiens STAT3
Osmium (II) complex MTT Assay Influence on cell viability N/A µM Caco-2 Homo sapiens
Osmium (II) complex MTT Assay Influence on cell viability N/A µM LO-2 Homo sapiens