Niflumic Acid

Name Value
Weight 282.221 g/mol
Zinc ID ZINC125031
Smiles O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1
Molecular formula C13H9F3N2O2
Mode of inhibition STAT and JAK; Non-peptide small molecule
CAS 4394-00-7

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Niflumic acid suppresses interleukin-13-induced asthma phenotypes. American journal of respiratory and critical care medicine Takako Nakano, Hiromasa Inoue, Satoru Fukuyama, Koichiro Matsumoto, Mikiko Matsumura, Miyuki Tsuda, Takafumi Matsumoto, Hisamichi Aizawa, Yoichi Nakanishi, 173, 11, 2006-06-01, 2006-03-09, 10.1164/rccm.200410-1420OC 10.1164/rccm.200410-1420OC 16528019 16528019

Vendors

Company Lnk to product
Tocris https://www.tocris.com/products/niflumic-acid_4112
Molport https://www.molport.com/shop/moleculelink/2-3-trifluoromethyl-phenyl-amino-pyridine-3-carboxylic-acid/140647
Caymanchemical https://www.caymanchem.com/product/70650/niflumic-acid
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/sigma/n0630?lang=pl&region=PL

Filter data

Compound Niflumic Acid
Experiment types Alcian-blue staining, BALF content analysis, RT-PCR, Western Blot
Concentrations 100.00, 30.00
Cell lines BEAS-2B, eosinophils, lung, lymphocytes, macrophages, neutrophils
Organisms Homo sapiens, Mus musculus
Animal models A/J
STAT proteins STAT6, p-STAT6
Other JAK2, MUC5AC, mCLCA1, mCLCA2, mCLCA3, mCLCA4, mCLCA5, mCLCA6, p-JAK2, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Niflumic Acid Alcian-blue staining Influence on trachea and intrapulmonary bronchi in presence of IL-13 30.00 mg/kg Mus musculus A/J
Niflumic Acid RT-PCR Influence on gene expression in trachea and intrapulmonary bronchi in presence of IL-13 30.00 mg/kg Mus musculus A/J
Niflumic Acid RT-PCR Influence on gene expression in trachea and intrapulmonary bronchi in presence of IL-13 30.00 mg/kg Mus musculus A/J
Niflumic Acid BALF content analysis Influence on airway responsiveness in presence of IL-13 30.00 mg/kg macrophages Mus musculus A/J
Niflumic Acid BALF content analysis Influence on airway responsiveness in presence of IL-13 30.00 mg/kg neutrophils Mus musculus A/J
Niflumic Acid BALF content analysis Influence on airway responsiveness in presence of IL-13 30.00 mg/kg lymphocytes Mus musculus A/J
Niflumic Acid BALF content analysis Influence on airway responsiveness in presence of IL-13 30.00 mg/kg eosinophils Mus musculus A/J
Niflumic Acid Western Blot Influence on protein activity in presence of IL-13 100.00 µM BEAS-2B Homo sapiens p-STAT6
Niflumic Acid Western Blot Influence on protein activity in presence of IL-13 100.00 µM BEAS-2B Homo sapiens STAT6
Niflumic Acid Western Blot Influence on protein activity in presence of IL-13 100.00 µM BEAS-2B Homo sapiens
Niflumic Acid Western Blot Influence on protein activity in presence of IL-13 100.00 µM BEAS-2B Homo sapiens
Niflumic Acid RT-PCR Influence on gene expression in lung tissue in presence of IL-13 30.00 mg/kg lung Mus musculus A/J
Niflumic Acid RT-PCR Influence on gene expression in lung tissue in presence of IL-13 30.00 mg/kg lung Mus musculus A/J
Niflumic Acid RT-PCR Influence on gene expression in lung tissue in presence of IL-13 30.00 mg/kg lung Mus musculus A/J
Niflumic Acid RT-PCR Influence on gene expression in lung tissue in presence of IL-13 30.00 mg/kg lung Mus musculus A/J
Niflumic Acid RT-PCR Influence on gene expression in lung tissue in presence of IL-13 30.00 mg/kg lung Mus musculus A/J
Niflumic Acid RT-PCR Influence on gene expression in lung tissue in presence of IL-13 30.00 mg/kg lung Mus musculus A/J
Niflumic Acid RT-PCR Influence on gene expression in lung tissue in presence of IL-13 30.00 mg/kg lung Mus musculus A/J