Ly5

Name Value
Weight 329.337 g/mol
Zinc ID ZINC101677919
Smiles NS(=O)(=O)c1cccc2c1C(=O)C=C(Nc1cccnc1)C2=O
Molecular formula C15H11N3O4S
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS 1436382-03-4

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
[Organization of military field surgery (on the 25th anniversary of the victory over Fascist Germany)]. Veterinariia A F Burdeniuk, 5, None, None, None, 10.18632/oncotarget.7338 10.18632/oncotarget.7338 4914331 PMC4914331
Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. PloS one Peter Y Yu, Heather L Gardner, Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K LeBlanc, Hui Xiao, Jiayuh Lin, Denis C Guttridge, Xiaokui Mo, Chad E Bennett, Christopher C Coss, Yonghua Ling, Mitch A Phelps, Peter Houghton, Cheryl A London, 12, 7, None, 2017-07-27, 10.1371/journal.pone.0181885 10.1371/journal.pone.0181885 28750090 PMC5531494

Vendors

Company Lnk to product
Glixx Laboratories http://glixxlabs.com/chemical-products/bioactive-screen-leads-p6/GLXC-05504

Filter data

Compound Ly5
Experiment types Alamar Blue staining , Immunohistochemistry, Luciferase activity, Western Blot
Concentrations 0.10, 0.50, 1.00, 10.00, 2.50, 20.00, 5.00, N/A
Cell lines ES-3, ES-6, ES-7, ES-8, EW8, JR-1, K7M2, MG63.3, OS-17, OS-17 (xenograft), RD, Rh30, SJSA
Organisms Homo sapiens, Mus musculus
Animal models SCID mice
STAT proteins STAT1, STAT3, p-STAT1, p-STAT3
Other GAPDH, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Ly5 Western Blot Influence on protein activity 0.50 µM Rh30 Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity 1.00 µM Rh30 Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity 0.50 µM Rh30 Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity 1.00 µM Rh30 Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity 0.50 µM Rh30 Homo sapiens
Ly5 Western Blot Influence on protein activity 1.00 µM Rh30 Homo sapiens
Ly5 Western Blot Influence on protein activity 0.50 µM EW8 Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity 1.00 µM EW8 Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity 0.50 µM EW8 Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity 1.00 µM EW8 Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity 0.50 µM EW8 Homo sapiens
Ly5 Western Blot Influence on protein activity 1.00 µM EW8 Homo sapiens
Ly5 Western Blot Influence on protein activity 0.50 µM RD Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity 1.00 µM RD Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity 0.50 µM RD Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity 1.00 µM RD Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity 0.50 µM RD Homo sapiens
Ly5 Western Blot Influence on protein activity 1.00 µM RD Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of OSM 1.00 µM SJSA Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity in presence of OSM 2.50 µM SJSA Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity in presence of OSM 1.00 µM SJSA Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity in presence of OSM 2.50 µM SJSA Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity in presence of OSM 1.00 µM SJSA Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of OSM 2.50 µM SJSA Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of IL-6 1.00 µM SJSA Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity in presence of IL-6 2.50 µM SJSA Homo sapiens p-STAT3
Ly5 Western Blot Influence on protein activity in presence of IL-6 1.00 µM SJSA Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity in presence of IL-6 2.50 µM SJSA Homo sapiens STAT3
Ly5 Western Blot Influence on protein activity in presence of IL-6 1.00 µM SJSA Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of IL-6 2.50 µM SJSA Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of IFNγ 1.00 µM SJSA Homo sapiens p-STAT1
Ly5 Western Blot Influence on protein activity in presence of IFNγ 2.50 µM SJSA Homo sapiens p-STAT1
Ly5 Western Blot Influence on protein activity in presence of IFNγ 1.00 µM SJSA Homo sapiens STAT1
Ly5 Western Blot Influence on protein activity in presence of IFNγ 2.50 µM SJSA Homo sapiens STAT1
Ly5 Western Blot Influence on protein activity in presence of IFNγ 1.00 µM SJSA Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of IFNγ 2.50 µM SJSA Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of IFNα 1.00 µM SJSA Homo sapiens p-STAT1
Ly5 Western Blot Influence on protein activity in presence of IFNα 2.50 µM SJSA Homo sapiens p-STAT1
Ly5 Western Blot Influence on protein activity in presence of IFNα 1.00 µM SJSA Homo sapiens STAT1
Ly5 Western Blot Influence on protein activity in presence of IFNα 2.50 µM SJSA Homo sapiens STAT1
Ly5 Western Blot Influence on protein activity in presence of IFNα 1.00 µM SJSA Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of IFNα 2.50 µM SJSA Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of IL-4 1.00 µM SJSA Homo sapiens p-STAT1
Ly5 Western Blot Influence on protein activity in presence of IL-4 2.50 µM SJSA Homo sapiens p-STAT1
Ly5 Western Blot Influence on protein activity in presence of IL-4 1.00 µM SJSA Homo sapiens STAT1
Ly5 Western Blot Influence on protein activity in presence of IL-4 2.50 µM SJSA Homo sapiens STAT1
Ly5 Western Blot Influence on protein activity in presence of IL-4 1.00 µM SJSA Homo sapiens
Ly5 Western Blot Influence on protein activity in presence of IL-4 2.50 µM SJSA Homo sapiens
Ly5 Alamar Blue staining Influence on cell viability N/A nM Rh30 Homo sapiens
Ly5 Alamar Blue staining Influence on cell viability N/A nM RD Homo sapiens
Ly5 Alamar Blue staining Influence on cell viability N/A nM JR-1 Homo sapiens
Ly5 Alamar Blue staining Influence on cell viability N/A nM ES-3 Homo sapiens
Ly5 Alamar Blue staining Influence on cell viability N/A nM ES-6 Homo sapiens
Ly5 Alamar Blue staining Influence on cell viability N/A nM ES-7 Homo sapiens
Ly5 Alamar Blue staining Influence on cell viability N/A nM ES-8 Homo sapiens
Ly5 Alamar Blue staining Influence on cell viability N/A nM OS-17 Homo sapiens
Ly5 Immunohistochemistry Influence on protein activity in tumor tissue 20.00 mg/kg OS-17 (xenograft) Mus musculus SCID mice
Ly5 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg OS-17 (xenograft) Mus musculus SCID mice p-STAT3
Ly5 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg OS-17 (xenograft) Mus musculus SCID mice
Ly5 Luciferase activity Influence on protein activity in tumor tissue 20.00 mg/kg OS-17 (xenograft) Mus musculus SCID mice
Ly5 Western Blot Influence on protein activity ex vivo 1.00 µM MG63.3 Mus musculus p-STAT3
Ly5 Western Blot Influence on protein activity ex vivo 5.00 µM MG63.3 Mus musculus p-STAT3
Ly5 Western Blot Influence on protein activity ex vivo 10.00 µM MG63.3 Mus musculus p-STAT3
Ly5 Western Blot Influence on protein activity ex vivo 20.00 µM MG63.3 Mus musculus p-STAT3
Ly5 Western Blot Influence on protein activity ex vivo 1.00 µM MG63.3 Mus musculus STAT3
Ly5 Western Blot Influence on protein activity ex vivo 5.00 µM MG63.3 Mus musculus STAT3
Ly5 Western Blot Influence on protein activity ex vivo 10.00 µM MG63.3 Mus musculus STAT3
Ly5 Western Blot Influence on protein activity ex vivo 20.00 µM MG63.3 Mus musculus STAT3
Ly5 Western Blot Influence on protein activity ex vivo 0.10 µM K7M2 Mus musculus p-STAT3
Ly5 Western Blot Influence on protein activity ex vivo 1.00 µM K7M2 Mus musculus p-STAT3
Ly5 Western Blot Influence on protein activity ex vivo 10.00 µM K7M2 Mus musculus p-STAT3
Ly5 Western Blot Influence on protein activity ex vivo 0.10 µM K7M2 Mus musculus STAT3
Ly5 Western Blot Influence on protein activity ex vivo 1.00 µM K7M2 Mus musculus STAT3
Ly5 Western Blot Influence on protein activity ex vivo 10.00 µM K7M2 Mus musculus STAT3