LLL12

Name Value
Weight 303.295 g/mol
Zinc ID ZINC96908204
Smiles NS(=O)(=O)c1cccc2c1C(=O)c1cccc(O)c1C2=O
Molecular formula C14H9NO5S
Mode of inhibition N/A
CAS 1260247-42-4

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy. Oncotarget Mingxin Zuo, Chenglong Li, Jiayuh Lin, Milind Javle, 6, 13, 2015-05-10, None, 10.18632/oncotarget.3458 10.18632/oncotarget.3458 25883212 PMC4484430

Vendors

Company Lnk to product
BioVision https://www.biovision.com/lll12.html

Filter data

Compound LLL12
Experiment types Body weight, Flow cytometry , Immunofluorescence, MTT Assay , RT-PCR, Tumor weight, Western Blot
Concentrations 0.50, 1.00, 10.00, 2.50, 5.00
Cell lines HepB, SNU387, SNU398, SNU398 (xenograft), SNU449
Organisms Homo sapiens, Mus musculus
Animal models athymic nude mice
STAT proteins STAT3, p-STAT3
Other Bcl-2, Bcl-xL, Cleaved caspase-3, Cyclin D1, DNMT1, GAPDH, Survivin, VEGF

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
LLL12 MTT Assay Influence on cell proliferation 10.00 µM SNU387 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 5.00 µM SNU387 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 2.50 µM SNU387 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 1.00 µM SNU387 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 0.50 µM SNU387 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 10.00 µM SNU398 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 5.00 µM SNU398 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 2.50 µM SNU398 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 1.00 µM SNU398 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 0.50 µM SNU398 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 10.00 µM SNU449 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 5.00 µM SNU449 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 2.50 µM SNU449 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 1.00 µM SNU449 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 0.50 µM SNU449 Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 10.00 µM HepB Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 5.00 µM HepB Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 2.50 µM HepB Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 1.00 µM HepB Homo sapiens
LLL12 MTT Assay Influence on cell proliferation 0.50 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU387 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU398 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM SNU449 Homo sapiens
LLL12 RT-PCR Influence on target gene activity 5.00 µM HepB Homo sapiens
LLL12 RT-PCR Influence on target gene activity 10.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens p-STAT3
LLL12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens p-STAT3
LLL12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens p-STAT3
LLL12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens p-STAT3
LLL12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens p-STAT3
LLL12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens p-STAT3
LLL12 Western Blot Influence on protein activity 5.00 µM HepB Homo sapiens p-STAT3
LLL12 Western Blot Influence on protein activity 10.00 µM HepB Homo sapiens p-STAT3
LLL12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens STAT3
LLL12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens STAT3
LLL12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens STAT3
LLL12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens STAT3
LLL12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens STAT3
LLL12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens STAT3
LLL12 Western Blot Influence on protein activity 5.00 µM HepB Homo sapiens STAT3
LLL12 Western Blot Influence on protein activity 10.00 µM HepB Homo sapiens STAT3
LLL12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL12 Western Blot Influence on protein activity 5.00 µM HepB Homo sapiens
LLL12 Western Blot Influence on protein activity 10.00 µM HepB Homo sapiens
LLL12 Flow cytometry Influence on cell cycle 5.00 µM SNU387 Homo sapiens
LLL12 Flow cytometry Influence on cell cycle 5.00 µM SNU398 Homo sapiens
LLL12 Flow cytometry Influence on cell cycle 5.00 µM SNU449 Homo sapiens
LLL12 Flow cytometry Influence on cell cycle 5.00 µM HepB Homo sapiens
LLL12 Immunofluorescence Influence on protein activity 5.00 µM SNU387 Homo sapiens p-STAT3
LLL12 Immunofluorescence Influence on protein activity 5.00 µM SNU398 Homo sapiens p-STAT3
LLL12 Tumor weight Influence on tumor cell growth and proliferation 5.00 mg/kg SNU398 (xenograft) Mus musculus athymic nude mice
LLL12 Body weight Influence on tumor cell growth and proliferation 5.00 mg/kg SNU398 (xenograft) Mus musculus athymic nude mice