KDI1

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition EGFR, STAT; peptide aptamer
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells. The Journal of biological chemistry Claudia Buerger, Kerstin Nagel-Wolfrum, Christian Kunz, Ilka Wittig, Karin Butz, Felix Hoppe-Seyler, Bernd Groner, 278, 39, 2003-09-26, 2003-07-02, 10.1074/jbc.M301629200 10.1074/jbc.M301629200 12842895 12842895

Filter data

Compound KDI1
Experiment types Colony formation assay , Immunofluorescence, Western Blot, XTT
Concentrations 0.10, 0.50, 1.00, 2.00
Cell lines Herc
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3 (Y705)
Other EGFR, EGFR-PY 1068, EGFR-PY 1148, EGFR-PY 845

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
KDI1 XTT Influence on cell proliferation in presence of EGF 0.10 µM Herc Homo sapiens
KDI1 XTT Influence on cell proliferation in presence of EGF 0.50 µM Herc Homo sapiens
KDI1 XTT Influence on cell proliferation in presence of EGF 1.00 µM Herc Homo sapiens
KDI1 XTT Influence on cell proliferation in presence of EGF 2.00 µM Herc Homo sapiens
KDI1 Colony formation assay Influence on cell motility 2.00 µM Herc Homo sapiens
KDI1 Western Blot Influence on protein activity in presence of EGF 0.50 µM Herc Homo sapiens
KDI1 Western Blot Influence on protein activity in presence of EGF 1.00 µM Herc Homo sapiens
KDI1 Western Blot Influence on protein activity in presence of EGF 0.50 µM Herc Homo sapiens
KDI1 Western Blot Influence on protein activity in presence of EGF 1.00 µM Herc Homo sapiens
KDI1 Western Blot Influence on protein activity in presence of EGF 0.50 µM Herc Homo sapiens
KDI1 Western Blot Influence on protein activity in presence of EGF 1.00 µM Herc Homo sapiens
KDI1 Western Blot Influence on protein activity in presence of EGF 0.50 µM Herc Homo sapiens
KDI1 Western Blot Influence on protein activity in presence of EGF 1.00 µM Herc Homo sapiens
KDI1 Western Blot Influence on protein activity in presence of EGF 0.50 µM Herc Homo sapiens p-STAT3 (Y705)
KDI1 Western Blot Influence on protein activity in presence of EGF 1.00 µM Herc Homo sapiens p-STAT3 (Y705)
KDI1 Western Blot Influence on protein activity in presence of EGF 0.50 µM Herc Homo sapiens STAT3
KDI1 Western Blot Influence on protein activity in presence of EGF 1.00 µM Herc Homo sapiens STAT3
KDI1 Immunofluorescence Influence on protein activity in presence of EGF 1.00 µM Herc Homo sapiens p-STAT3 (Y705)
KDI1 Immunofluorescence Influence on protein activity in presence of EGF 1.00 µM Herc Homo sapiens STAT3