ISS-610 prodrugs

Name Value
Weight 503.448 g/mol
Zinc ID ZINC3990015
Smiles CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)c1ccc(C#N)cc1)C(=O)O
Molecular formula C23H26N3O8P
Mode of inhibition Direct STAT SH2; peptidomimetic
CAS 725233-55-6

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
Phosphotyrosine prodrugs: design, synthesis and anti-STAT3 activity of ISS-610 aryloxy triester phosphoramidate prodrugs. MedChemComm Ageo Miccoli, Binar A Dhiani, Youcef Mehellou, 10, 2, 2019-02-01, 2018-11-07, 10.1039/c8md00244d 10.1039/c8md00244d 30881608 PMC6390693

Vendors

Company Lnk to product
MedKoo Biosciences https://www.medkoo.com/products/7586

Filter data

Compound ISS-610 prodrugs
Experiment types Western Blot
Concentrations 0.10, 1.00, 10.00, 100.00, 30.00
Cell lines MDA-MB-468
Organisms Homo sapiens
Animal models
STAT proteins STAT3
Other Bcl-xL, Survivin, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
ISS-610 prodrugs Western Blot Influence on protein activity 100.00 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 100.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 100.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 100.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 100.00 µM MDA-MB-468 Homo sapiens STAT3
ISS-610 prodrugs Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 100.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 100.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens
ISS-610 prodrugs Western Blot Influence on protein activity 100.00 µM MDA-MB-468 Homo sapiens