Honokiol

Name Value
Weight 266.340 g/mol
Zinc ID ZINC1536
Smiles C=CCc1ccc(O)c(-c2ccc(O)c(CC=C)c2)c1
Molecular formula C18H18O2
Mode of inhibition EGFR, SHP1, STAT; Natural product
CAS 35354-74-6

Clinical Trials

Study title Status Conditions Link
Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing. Completed Gingival Diseases NCT00966953
Effect of a Sugar-Free Chewing Gum Containing Magnolia Bark Extract on Caries Lesions in Healthy Adult Volunteers Unknown status Dental Caries NCT02310308
Clinical Trial to Evaluate Papilocare® Gel Efficacy Into Repairment of Cervical Lesions Caused by HPV Recruiting HPV Infection|Lesion Cervix NCT04210336

References

Publication DOI Pubmed PMCID
Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells. Inflammation Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Takashi Matsuo, 41, 6, None, None, 10.1007/s10753-018-0854-z 10.1007/s10753-018-0854-z 30039429 30039429

Vendors

Company Lnk to product
MedChemExpress https://www.medchemexpress.com/honokiol.html
Selleckchem https://www.selleckchem.com/products/Honokiol.html
Caymanchemical https://www.caymanchem.com/product/14597/honokiol
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/sigma/h4914?lang=pl&region=PL

Filter data

Compound Honokiol
Experiment types ELISA, Western Blot
Concentrations 12.50, 25.00, 3.12, 50.00, 6.25
Cell lines TR146
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, p-STAT1, p-STAT3
Other Akt, Akt , CXCL10, CXCL11, GAPDH, p-Akt

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 50.00 µM TR146 Homo sapiens
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 25.00 µM TR146 Homo sapiens
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 12.50 µM TR146 Homo sapiens
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 6.25 µM TR146 Homo sapiens
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 3.12 µM TR146 Homo sapiens
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 50.00 µM TR146 Homo sapiens
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 25.00 µM TR146 Homo sapiens
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 12.50 µM TR146 Homo sapiens
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 6.25 µM TR146 Homo sapiens
Honokiol ELISA Influence on chemokine ligand expression in presence of IL-27 3.12 µM TR146 Homo sapiens
Honokiol Western Blot Influence on protein activity 50.00 µM TR146 Homo sapiens p-STAT3
Honokiol Western Blot Influence on protein activity 25.00 µM TR146 Homo sapiens p-STAT3
Honokiol Western Blot Influence on protein activity 50.00 µM TR146 Homo sapiens STAT3
Honokiol Western Blot Influence on protein activity 25.00 µM TR146 Homo sapiens STAT3
Honokiol Western Blot Influence on protein activity 50.00 µM TR146 Homo sapiens p-STAT1
Honokiol Western Blot Influence on protein activity 25.00 µM TR146 Homo sapiens p-STAT1
Honokiol Western Blot Influence on protein activity 50.00 µM TR146 Homo sapiens STAT1
Honokiol Western Blot Influence on protein activity 25.00 µM TR146 Homo sapiens STAT1
Honokiol Western Blot Influence on protein activity 50.00 µM TR146 Homo sapiens
Honokiol Western Blot Influence on protein activity 25.00 µM TR146 Homo sapiens
Honokiol Western Blot Influence on protein activity 50.00 µM TR146 Homo sapiens
Honokiol Western Blot Influence on protein activity 25.00 µM TR146 Homo sapiens
Honokiol Western Blot Influence on protein activity 50.00 µM TR146 Homo sapiens
Honokiol Western Blot Influence on protein activity 25.00 µM TR146 Homo sapiens