Homoharringtonine
Name | Value |
---|---|
Weight | 545.629 g/mol |
Zinc ID | ZINC43450324 |
Smiles | COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@@H]1C(OC)=C[C@]23CCCN2CCc2cc4c(cc2[C@@H]13)OCO4 |
Molecular formula | C29H39NO9 |
Mode of inhibition | N/A |
CAS | 26833-87-4 |
Clinical Trials
References
Vendors
Company | Lnk to product |
---|---|
MERCK/Sigma Aldrich | https://www.sigmaaldrich.com/PL/pl/product/sigma/sml1091 |
Filter data
Compound | Homoharringtonine |
Experiment types | Colony formation assay , Flow cytometry- annexin V binding and propidium iodide staining, Hoechst 33258 assay, MTT, Trypan blue exclusion assay, Tumor volume, Tumor wight , Western Blot |
Concentrations | 0.12, 0.25, 0.50, 1.00, 10.00, 160.00, 2.00, 20.00, 3.00, 4.00, 40.00, 5.00, 6.00, 60.00, 80.00 |
Cell lines | A549, H1975, H1975 (xenograft), HEL, HL60, K562, Leukemia patient cells |
Organisms | Homo sapiens, Mus musculus |
Animal models | |
STAT proteins | STAT3, STAT5, p-STAT3, p-STAT3 (S727), p-STAT3 (Y705), p-STAT5 |
Other | AKT1/2/3, Actin, BAX, BCL2, Bcl-xL, Caspase 3, Caspase 9, Cytochrome C, EGFR, ERK1/2, GAPDH, JAK1, JAK2, MCL1, PARP, PDK1, Pim-1, Smad2, Smad3, Survivin, c-Myc, p-AKT1/2/3, p-EGFR, p-ERK1/2, p-JAK1, p-JAK2, p-PDK1, p-Smad2, p-Smad3 |