GYY4137

Name Value
Weight 376.470 g/mol
Zinc ID N/A
Smiles COC1=CC=C(C=C1)P(=S)(N2CCOCC2)S.C1COCCN1
Molecular formula C11H16NO2PS2.C4H9NO
Mode of inhibition N/A
CAS 106740-09-4

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
GYY4137, a hydrogen sulfide (H₂S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. International journal of oncology Sen Lu, Yun Gao, Xinli Huang, Xuehao Wang, 44, 4, None, 2014-02-14, 10.3892/ijo.2014.2305 10.3892/ijo.2014.2305 24535538 24535538

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/gyy4137.html
MedChemExpress https://www.medchemexpress.com/gyy4137.html?src=google-product&gclid=CjwKCAiA8bqOBhANEiwA-sIlNzL8cmuVJ5SD7k9X37UOafUr-DWJaIZnhiXG6B2EzyHWyTFqx8TFABoCXcsQAvD_BwE
Tocris https://www.tocris.com/products/gyy-4137-morpholine-salt_3658?gclid=CjwKCAiA8bqOBhANEiwA-sIlNyf8SrxhGBP_gLC3HGMCTSdZpZrIzNv5drufLRZ9r6qYRvmHt2NIQhoCp7sQAvD_BwE

Filter data

Compound GYY4137
Experiment types Flow cytometry- annexin V binding and propidium iodide staining, Immunohistochemistry, MTT, Tumor volume, Western Blot
Concentrations 10.00, 100.00, 20.00, 200.00, 400.00, 50.00
Cell lines Bel7402, Bel7402(xenograft), HepG2, HepG2(xenograft)
Organisms Homo sapiens, Mus musculus
Animal models nude
STAT proteins STAT3, p-STAT3(S727), p-STAT3(Y705)
Other Bcl-2, Cyclin D1, HIF-1α, JAK2, Mcl-1, Mcl-2, Survivin, VEGF, cyclin D1, p-JAK2, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
GYY4137 Western Blot Influence on protein activity in presence of IL-6 50.00 µM HepG2 Homo sapiens p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 100.00 µM HepG2 Homo sapiens p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 200.00 µM HepG2 Homo sapiens p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 400.00 µM HepG2 Homo sapiens p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 50.00 µM HepG2 Homo sapiens p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 100.00 µM HepG2 Homo sapiens p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 200.00 µM HepG2 Homo sapiens p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 400.00 µM HepG2 Homo sapiens p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 50.00 µM HepG2 Homo sapiens STAT3
GYY4137 Western Blot Influence on protein activity in presence of IL-6 100.00 µM HepG2 Homo sapiens STAT3
GYY4137 Western Blot Influence on protein activity in presence of IL-6 200.00 µM HepG2 Homo sapiens STAT3
GYY4137 Western Blot Influence on protein activity in presence of IL-6 400.00 µM HepG2 Homo sapiens STAT3
GYY4137 Western Blot Influence on protein activity in presence of IL-6 50.00 µM Bel7402 Homo sapiens p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 100.00 µM Bel7402 Homo sapiens p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 200.00 µM Bel7402 Homo sapiens p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 400.00 µM Bel7402 Homo sapiens p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 50.00 µM Bel7402 Homo sapiens p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 100.00 µM Bel7402 Homo sapiens p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 200.00 µM Bel7402 Homo sapiens p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 400.00 µM Bel7402 Homo sapiens p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in presence of IL-6 50.00 µM Bel7402 Homo sapiens STAT3
GYY4137 Western Blot Influence on protein activity in presence of IL-6 100.00 µM Bel7402 Homo sapiens STAT3
GYY4137 Western Blot Influence on protein activity in presence of IL-6 200.00 µM Bel7402 Homo sapiens STAT3
GYY4137 Western Blot Influence on protein activity in presence of IL-6 400.00 µM Bel7402 Homo sapiens STAT3
GYY4137 Western Blot Influence on protein activity in presence of IL-6 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity in presence of IL-6 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity in presence of IL-6 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity in presence of IL-6 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity in presence of IL-6 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity in presence of IL-6 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity in presence of IL-6 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity in presence of IL-6 400.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM Bel7402 Homo sapiens
GYY4137 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycyle 100.00 µM HepG2 Homo sapiens
GYY4137 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycyle 200.00 µM HepG2 Homo sapiens
GYY4137 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycyle 400.00 µM HepG2 Homo sapiens
GYY4137 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycyle 100.00 µM Bel7402 Homo sapiens
GYY4137 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycyle 200.00 µM Bel7402 Homo sapiens
GYY4137 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycyle 400.00 µM Bel7402 Homo sapiens
GYY4137 MTT Influence on cell apoptosis 50.00 µM Bel7402 Homo sapiens
GYY4137 MTT Influence on cell apoptosis 100.00 µM Bel7402 Homo sapiens
GYY4137 MTT Influence on cell apoptosis 200.00 µM Bel7402 Homo sapiens
GYY4137 MTT Influence on cell apoptosis 400.00 µM Bel7402 Homo sapiens
GYY4137 MTT Influence on cell apoptosis 50.00 µM HepG2 Homo sapiens
GYY4137 MTT Influence on cell apoptosis 100.00 µM HepG2 Homo sapiens
GYY4137 MTT Influence on cell apoptosis 200.00 µM HepG2 Homo sapiens
GYY4137 MTT Influence on cell apoptosis 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM HepG2 Homo sapiens
GYY4137 Western Blot Influence on protein activity 50.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 100.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 200.00 µM Bel7402 Homo sapiens
GYY4137 Western Blot Influence on protein activity 400.00 µM Bel7402 Homo sapiens
GYY4137 Tumor volume Infuence on tumor growth 10.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Tumor volume Infuence on tumor growth 20.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Tumor volume Infuence on tumor growth 50.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Tumor volume Infuence on tumor growth 10.00 mg/kg Bel7402(xenograft) Mus musculus nude
GYY4137 Tumor volume Infuence on tumor growth 20.00 mg/kg Bel7402(xenograft) Mus musculus nude
GYY4137 Tumor volume Infuence on tumor growth 50.00 mg/kg Bel7402(xenograft) Mus musculus nude
GYY4137 Immunohistochemistry Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude p-STAT3(Y705)
GYY4137 Immunohistochemistry Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude p-STAT3(Y705)
GYY4137 Immunohistochemistry Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude p-STAT3(Y705)
GYY4137 Immunohistochemistry Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude STAT3
GYY4137 Immunohistochemistry Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude STAT3
GYY4137 Immunohistochemistry Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude STAT3
GYY4137 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude p-STAT3(Y705)
GYY4137 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude p-STAT3(S727)
GYY4137 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude STAT3
GYY4137 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude STAT3
GYY4137 Western Blot Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude STAT3
GYY4137 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg HepG2(xenograft) Mus musculus nude
GYY4137 Western Blot Influence on protein activity in tumor tissue 50.00 mg/kg HepG2(xenograft) Mus musculus nude