Cucurbitacin B

Name Value
Weight 558.712 g/mol
Zinc ID ZINC4097797
Smiles CC(=O)OC(C)(C)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C
Molecular formula C32H46O8
Mode of inhibition JAK2, STAT3; Natural product
CAS 6199-67-3

Clinical Trials

References

Vendors

Company Lnk to product
AK Scientific Inc. https://aksci.com/item_detail.php?cat=X1115
MedChemExpress https://www.medchemexpress.com/Cucurbitacin-B.html
TargetMol https://www.targetmol.com/compound/Cucurbitacin-B
MERCK (Sigma Aldrich) https://www.sigmaaldrich.com/catalog/product/sigma/c8499?lang=pl&region=PL
Caymanchemical https://www.caymanchem.com/product/14820
Mcule https://mcule.com/MCULE-7414589561/
Selleckchem https://www.selleckchem.com/products/cucurbitacin-b.html

Filter data

Compound Cucurbitacin B
Experiment types AO/EB staining fluorescen microscopy, BrdU incorporation-ELISA, ELISA, LDH release assay, Luciferase activity, MTT, RT-qPCR, TUNEL assay, Western Blot
Concentrations 0.01, 0.03, 0.05, 0.50, 1.00, 10.00, 20.00, 40.00, 60.00, 80.00
Cell lines HCT-116, HT-29, Microglia
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, p-STAT1, p-STAT3
Other ARE/HO-1, Bad, Bak, Bax, Bcl-2, Bcl-xL, Bim, COX-2, Cleaved Caspase-3, Cyclin D1, EGFR, ERK, HO-1, HQO1, JAK1, JNK, Nf-κB, Nrf2, TBP, iNOS, p-ERK, p-IκBα, p-JAK1, p-JNK, p-p38, p-p65, p27kip1, p38, p65, pEGFR, tubulin, α-tubulin, β-actin

Experiments