CJ-1383

Name Value
Weight 0.000 g/mol
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT SH2; Peptidomimetic
CAS GLXC-21813

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors. ACS medicinal chemistry letters Jianyong Chen, Longchuan Bai, Denzil Bernard, Zaneta Nikolovska-Coleska, Cindy Gomez, Jian Zhang, Han Yi, Shaomeng Wang, 1, 2, 2010-05-13, None, 10.1021/ml100010j 10.1021/ml100010j 20596242 PMC2892918

Filter data

Compound CJ-1383
Experiment types Flow cytometry , Fluorescence polarization assay, Western Blot
Concentrations 1.25, 10.00, 2.50, 20.00, 5.00, N/A
Cell lines MDA-MB-468
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3
Other Bcl-xL, Cas-3, Cleaved Cas-3, Cleaved-PARP, Cyclin D1, GAPDH, PARP

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
CJ-1383 Fluorescence polarization assay Protein binding activity N/A µM Homo sapiens
CJ-1383 Flow cytometry Influence on cell apoptosis 20.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Flow cytometry Influence on cell apoptosis 10.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Flow cytometry Influence on cell apoptosis 5.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Flow cytometry Influence on cell apoptosis 2.50 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens STAT3
CJ-1383 Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens STAT3
CJ-1383 Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens STAT3
CJ-1383 Western Blot Influence on protein activity 2.50 µM MDA-MB-468 Homo sapiens STAT3
CJ-1383 Western Blot Influence on protein activity 1.25 µM MDA-MB-468 Homo sapiens STAT3
CJ-1383 Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens p-STAT3
CJ-1383 Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens p-STAT3
CJ-1383 Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens p-STAT3
CJ-1383 Western Blot Influence on protein activity 2.50 µM MDA-MB-468 Homo sapiens p-STAT3
CJ-1383 Western Blot Influence on protein activity 1.25 µM MDA-MB-468 Homo sapiens p-STAT3
CJ-1383 Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 2.50 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 1.25 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 2.50 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 1.25 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 2.50 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 1.25 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 2.50 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 1.25 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 2.50 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 1.25 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 2.50 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 1.25 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 2.50 µM MDA-MB-468 Homo sapiens
CJ-1383 Western Blot Influence on protein activity 1.25 µM MDA-MB-468 Homo sapiens