Chromone nicotinyl hydrazone 1

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT DBD; Non-peptide small molecule
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem : a European journal of chemical biology Judith Müller, Bianca Sperl, Wolfgang Reindl, Anke Kiessling, Thorsten Berg, 9, 5, 2008-03-25, None, 10.1002/cbic.200700701. 10.1002/cbic.200700701. 18247434 18247434

Filter data

Compound Chromone nicotinyl hydrazone 1
Experiment types EMSA, Fluorescence polarization assay, Western Blot
Concentrations 100.00, 200.00, 400.00, 50.00, 800.00, N/A
Cell lines Daudi, K562
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, STAT5, STAT5B, p-STAT1, p-STAT3, p-STAT5
Other Actin, Fos, Jun

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Chromone nicotinyl hydrazone 1 Fluorescence polarization assay Protein binding activity N/A µM STAT5B
Chromone nicotinyl hydrazone 1 Fluorescence polarization assay Protein binding activity N/A µM STAT3
Chromone nicotinyl hydrazone 1 Fluorescence polarization assay Protein binding activity N/A µM STAT1
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 100.00 µM K562 Homo sapiens STAT5
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 200.00 µM K562 Homo sapiens STAT5
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 400.00 µM K562 Homo sapiens STAT5
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 800.00 µM K562 Homo sapiens STAT5
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 100.00 µM K562 Homo sapiens
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 200.00 µM K562 Homo sapiens
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 400.00 µM K562 Homo sapiens
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 800.00 µM K562 Homo sapiens
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 100.00 µM K562 Homo sapiens
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 200.00 µM K562 Homo sapiens
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 400.00 µM K562 Homo sapiens
Chromone nicotinyl hydrazone 1 EMSA Protein binding activity 800.00 µM K562 Homo sapiens
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 50.00 µM Daudi Homo sapiens p-STAT5
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 100.00 µM Daudi Homo sapiens p-STAT5
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 200.00 µM Daudi Homo sapiens p-STAT5
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 400.00 µM Daudi Homo sapiens p-STAT5
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 50.00 µM Daudi Homo sapiens STAT5
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 100.00 µM Daudi Homo sapiens STAT5
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 200.00 µM Daudi Homo sapiens STAT5
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 400.00 µM Daudi Homo sapiens STAT5
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 50.00 µM Daudi Homo sapiens
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 100.00 µM Daudi Homo sapiens
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 200.00 µM Daudi Homo sapiens
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 400.00 µM Daudi Homo sapiens
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 50.00 µM Daudi Homo sapiens p-STAT3
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 100.00 µM Daudi Homo sapiens p-STAT3
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 200.00 µM Daudi Homo sapiens p-STAT3
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 400.00 µM Daudi Homo sapiens p-STAT3
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 50.00 µM Daudi Homo sapiens STAT3
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 100.00 µM Daudi Homo sapiens STAT3
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 200.00 µM Daudi Homo sapiens STAT3
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 400.00 µM Daudi Homo sapiens STAT3
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 50.00 µM Daudi Homo sapiens p-STAT1
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 100.00 µM Daudi Homo sapiens p-STAT1
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 200.00 µM Daudi Homo sapiens p-STAT1
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 400.00 µM Daudi Homo sapiens p-STAT1
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 50.00 µM Daudi Homo sapiens STAT1
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 100.00 µM Daudi Homo sapiens STAT1
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 200.00 µM Daudi Homo sapiens STAT1
Chromone nicotinyl hydrazone 1 Western Blot Influence on protein activity in presence of IFN 400.00 µM Daudi Homo sapiens STAT1