Capsaicin

Name Value
Weight 305.418 g/mol
Zinc ID ZINC1530575
Smiles COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O
Molecular formula C18H27NO3
Mode of inhibition STAT and gp130; Natural product
CAS 404-86-4

Clinical Trials

Study title Status Conditions Link
Clinical Trial Assessing the Efficacy of Capsaicin Patch (Qutenza®) in Cancer Patients With Neuropathic Pain Recruiting Neuropathic Pain NCT03317613
Influence on Cough and Airway Symptoms by Oral Capsaicin Recruiting Cough NCT04125563
Capsaicin for the Treatment of Cannabinoid Hyperemesis Syndrome Not yet recruiting Cannabinoid Hyperemesis Syndrome NCT04283292
Capsaicin 8% Patch for Spinal Cord Injury Neuropathic Pain Recruiting Spinal Cord Injuries|Neuropathic Pain NCT02441660
Sickle Cell Pain: Intervention With Capsaicin Exposure Active, not recruiting Neuropathic Pain|Sickle Cell Disease NCT03899246
CAPSAICIN Trial: Assessing Capsaicin as a Chemopreventive Agent for Prostate Cancer Unknown status Prostate Cancer NCT02037464
Esophageal capsaĂŻcin Infusion and Mucosal Integrity Completed TRPV1 Protein, Human|Capsaicin|Electric Impedance|Esophagus|Intracellular Space|Pain Measurement|Microscopy, Electron NCT02603783
Pain Thresholds Under High-dose Topical Capsaicin Completed Pain NCT02570841
Chest Pain Perception and Capsaicin Sensitivity Unknown status Chest Pain NCT02346903
Chest Pain Perception and Capsaicin Sensitivity in Patients With Acute Cardiac Ischemia Unknown status Chest Pain NCT02346916
Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis Completed Nonallergic Irritant Rhinitis NCT02493257
Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects Completed Healthy NCT00655811
The Qutenza Patch as Treatment for Disabling Treprostinil (Remodulin) Infusion Site Pain Completed Pulmonary Hypertension|Pulmonary Arterial Hypertension NCT01260454
fMRI and Visceral Perception Upon Capsaicin Infusion Recruiting Irritable Bowel Syndrome|Colonic Diseases, Functional|Dyspepsia|Gastrointestinal Diseases|Abdominal Pain|Visceral Pain NCT02551029
Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status End Stage Renal Failure|Neuropathic Pain NCT01704339
A Study to Evaluate Efficacy and Safety of a Single Application of Capsaicin 8%Transdermal Delivery System Compared to Placebo in Reducing Pain Intensity in Subjects With Painful Diabetic Peripheral Neuropathy (PDPN) Completed Diabetic Peripheral Neuropathy|Pain NCT01533428
A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis Completed Knee Osteoarthritis NCT03576508
Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis? Completed Osteoarthritis, Knee NCT03146689
The Efficacy and Safety Profile of Capsaicin 8% Patch Versus 5% Lidocaine Patch in Males With Diabetic Neuropathy Completed Diabetic Nerve Problems|Diabetic Neuropathy|Diabetic Complications Neurological NCT04238208
Neuro-immunological Analysis of Idiopathic Rhinitis Patients and Controls Treated With Capsaicin. Completed Idiopathic Rhinitis Patients|Healthy Controls NCT01223820
The Effect of Capsaicin and Cinnamaldehyde on Intestinal Permeability Completed Healthy NCT01667523
Qutenza (Topical Capsaicin 8%) for Painful Arteriovenous Fistulae Unknown status Neuropathic Pain|Arteriovenous Fistulae NCT01748422
Pre-emptive Analgesia With Qutenza in Lower Limb Amputation Unknown status Neuropathic Pain|Lower Limb Amputation NCT01748435
The Efficacy of Capsaicin Sensitivity Testing in Patients With Irritable Larynx Syndrome Withdrawn Cough|Larynx NCT02065128
Capsaicin Effect on Cytokines Profile in Dyslipidemia Unknown status Dyslipidemia|Overweight or Obesity NCT02823912
Capsaicin Energy Expenditure and Glucose Metabolism Recruiting Obesity|Insulin Resistance NCT03859583
Study of Possible Changes in QST After Application of Capsaicin on Patients With Peripheral Neuropathic Pain Completed Peripheral Nerve Injury|Postherpetic Neuralgia NCT01596491
Efficacy of Topical Capsaicin on Chronic Neck Pain Unknown status Chronic Neck Pain NCT01200745
0.075% Capsaicin Lotion for the Treatment of Painful Diabetic Neuropathy Completed Peripheral Diabetic Neuropathy NCT03113448
Topical Capsaicin for Cyclical Vomiting Completed Cyclical Vomiting NCT03223350
Observation of the Use of QUTENZA™ in Standard Clinical Practice Completed Peripheral Neuropathic Pain NCT01737294
A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin Active, not recruiting Capsaicin|Ultaviolet B Light Burn|Neuropathic Pain|Lidocaine NCT03587220
Efficacy of Topical Capsaicin Cream for Stable Angina Terminated Stable Angina NCT01231750
Double-blind Trial of Mannitol Cream to Block the Effect of Capsaicin Cream Completed Pain NCT01963910
Capsaicin in Treatment of Rhinogenic Headache Unknown status Headache Disorders NCT03330639
Capsaicin Nanoparticle in Patient With Painful Diabetic Neuropathy Unknown status Painful Diabetic Neuropathy NCT01125215
Sensory Function After Wound Instillation of Capsaicin Completed Primary Hyperalgesia NCT00583180
The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough. Unknown status Chronic Cough NCT01807832
A Study of Efficacy and Safety of Qutenza in Patients With Post-operative Peripheral Neuropathic Pain Completed Post-operative Peripheral Neuropathic Pain NCT02171182
ATP and Capsaicin Cough Provocation Test in Chronic Cough and Bronchiectasis Recruiting Chronic Cough|Bronchiectasis NCT03638063
A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia Unknown status Vestibulodynia NCT02854670
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls Completed Rhinitis NCT01862523
Trial to Evaluate the Efficacy of Topical Capsaicin to Reduce Pain and Improve Health-related Quality of Life in Adults With Chronic Myofascial Neck Pain Withdrawn Myofascial Pain Syndrome NCT00795106
Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery Recruiting Breast Cancer Patient NCT03794388
Efficacity of a Standardized Hypnotic Message During the Application of a Qutenza (Capsaicin) 8% Patch Completed Pain NCT02822625
The Effect of Ablation of Epidermal Nerve Fibers Using Capsaicin Cream Completed Pain NCT01883102
Capsaicin Patches In Knee Osteoarthritis In Obese Patients Terminated Pain NCT03153813
Efficacy and Safety Study of Topical Capsaicin in Painful Diabetic Neuropathy Completed Diabetic Polyneuropathy NCT00993070
Human Safety of Capsaicin Inhalation Challenge Testing for Young and Older Men Completed COPD NCT01621685
Capsaicin on Salty Gustatory Cortices Completed Volunteers NCT01974037
Effects of Capsaicin on the Structure, Distribution, and Function of Cutaneous Small Nerve Fibers in Psoriatic Skin Terminated Psoriasis NCT00697034
A Study to Investigate the Tolerability and Effects on Epidermal Nerve Fiber Density of Multiple Low-Concentrations of NGX-1998 in Healthy Volunteers Completed Pain NCT00912262
Effect Of PF-06305591 On Capsaicin And Capsaicin/Heat-Induced Neurogenic Flare Completed Healthy NCT01797796
Fenobam on Heat/Capsaicin Induced Hyperalgesia in Healthy Volunteers Completed Hyperalgesia|Allodynia NCT01981395
Acute Response Capsaicin Flare Study Completed Healthy NCT01147432
Capsaicin Patch 8 % for the Treatment of Persistent Pain After Inguinal Herniotomy Terminated Persistent Pain After Inguinal Herniotomy NCT01699854
Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch Completed or Peripheral Nerve Injury (PNI)|Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) NCT01416116
Capsaicin-induced Muscle Pain in Humans Completed Healthy NCT02377180
Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch Completed Pruritus NCT02769910
Cervical Capsaicin for Labor Induction and Pain Relief Withdrawn Labor Pain|Pregnancy Loss|Labor Induction NCT00771511
Study of Capsaicin Patch for the Management of Peripheral Neuropathic Pain Completed Peripheral Nerve Injury|Postherpetic Neuralgia NCT02228928
A Study to Compare QUTENZA With Pregabalin for the Treatment of Peripheral Neuropathic Pain (PNP) After 8 Weeks of Treatment Completed Non-diabetic Painful Peripheral Polyneuropathy|Postherpetic Neuralgia (PHN)|Peripheral Nerve Injury (PNI) NCT01713426
Study of Three Capsaicin Dermal Liquid Formulations on Epidermal Nerve Fiber Immunostaining and Sensory Function Completed Pain NCT00528216
Probiotics and Capsaicin Evoked Coughs Recruiting Atopic Asthma NCT03603522
Topical Local Anaesthesia and Cooling During Capsaicin 8% Patch Application Completed Pain NCT01523951
Efficacy Study on Symptomatic Control of Patient With Knee Osteoarthritis Between 0.0125% of Capsaicin to Placebo Completed Osteoarthritis, Knee Joint|Capsicum NCT00471055
Study to Investigate the Effects Single Oral Dose of AZD1386 (Capsaicin) Completed Capsaicin Evoked Pain|Heat Sensitivity NCT00692146
Capsaicin Lozenges in Treating Patients With Mucositis Caused by Radiation Therapy Completed Head and Neck Cancer|Radiation Toxicity NCT00003610
FS-67 in the Treatment of Pediatric Patients With Ankle Sprain Completed Ankle Sprain NCT01037816
Comparison of Cold Dry Air Exposure, Discs and Capsaicin Unknown status Nasal Hyper Reactivity NCT02334605
Stimulation of Sensation and Improvement in Swallowing Using Oral Capsaicin Completed Dysphagia|Gastroesophageal Reflux NCT01053286
Capsaicin + Diclofenac Gel in Acute Back Pain or Neck Pain Completed Acute Pain NCT02700815
Desensitization of Nociceptive Afferents by Application of Topical Capsaicin, Trans-cinnamaldehyde and L-menthol Unknown status Pain|Pruritus|Neuropathic Pain|Dermatology/Skin - Other NCT03132142
Response of Topical Capsaicin in Alopecia Areata Completed Alopecia Areata NCT00176969
Biomarker Study in Participants With Migraine Completed Migraine Disorders NCT02766517
Safety and Effectiveness of Repeated Administration of QUTENZA Patches for Treatment of Pain Caused by Nerve Damage Completed Neuralgia, Postherpetic NCT01252160
A Study To Assess The Effect Of SB-705498 In A Capsaicin Challenge Model Completed Rhinitis NCT00731250
Does the Application of Cold Decreases the Pain Associated in the Pose of a Patch of Capsaicine at High Concentration on the Carrier Patients of Localized Neuropathic Pains ? - DIDOCAP Recruiting Localized Neuropathic Pain NCT02869867
Quantitative Ultrasound Response of Capsaicin Not yet recruiting Central Sensitisation NCT03944889
Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Unknown status Non-allergic Rhinitis NCT02288156
Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy Unknown status HIV Infections NCT00061152
Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain Completed Neuralgia|Pain|Peripheral Nervous System Diseases|Herpes Zoster NCT00034710
Comparison of the Bioavailability of Diclofenac in a Combination Product (Diclofenac 2% + Capsaicin 0.075% Topical Gel) With Two Diclofenac Only Products, Diclofenac Mono Gel 2% and Voltarol® 12 Hour Emulgel 2.32% Gel, in Healthy Volunteers Completed Healthy NCT03074162
Intranasal SB-705498 in Non-allergic Rhinitis Patients Completed Rhinitis NCT01439308
Qutenza®-Remodulin® in Pulmonary Arterial Hypertension Patients Completed Pulmonary Hypertension|Pain NCT01393795
Capsaicin-Evoked Pain in Patients With CRPS Completed CRPS (Complex Regional Pain Syndromes) NCT00468390
A Study to Evaluate the Long-term Safety of Repeated QUTENZA Administration for Treatment of Pain Caused by Nerve Damage in Diabetic Patients Completed Painful Diabetic Peripheral Neuropathy (PDPN) NCT01478607
Cough Desensitization Therapy for Cough Hypersensitivity Syndrome Recruiting Cough NCT04256733
Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults Completed Cough NCT01854268
A Phase 2 Clinical Trial Examining the Effects on Osteoarthritic Knee Pain of CGS-200-1, CGS-200-5 and Vehicle Control Completed Osteoarthritis, Knee|Pain NCT03528369
High Definition Transcranial Direct Current Stimulation Motor Cortex Versus Insula Unknown status Pain NCT03216707
Effects of ICA-105665 Using the Intradermal Capsaicin and Ultraviolet B (UV-B) Models in Healthy Male Subjects Completed Healthy NCT00962663
MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough Recruiting Cough|Cough Variant Asthma|Upper-Airway Cough Syndrome|GERD|Allergic Rhinitis NCT03363698
The Functional Consequences of the CTNS-deletion for the TRPV1-receptor in Cystinosis Patients Completed Cystinosis NCT02533076
Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia Completed Pain|Hyperalgesia NCT00373893
Effect of Sex Hormone During the Menstrual Cycle on Capsaicin Evoked Cough Responses Recruiting Asthma NCT04233762
The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status Hyperalgesia NCT00886106
The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status Hyperalgesia NCT00789386
A Human Experimental Model for Neuropathic Pain Using Combined Application of Capsaicin and Local Anesthetics Completed Ipsi- and Contralateral Hypoesthesia NCT01540877
Capsaicin to Control Pain Following Third Molar Extraction Completed Facial Pain NCT00008476
Capsaicin to Control Pain Following Third Molar Extraction Completed Healthy|Tooth Extraction NCT00088686
Neuromodulation of Lidocaine and Capsaicin Cream Effects on Pain Experience Completed Pain NCT03102710
Spinal and Supra-Spinal Pain Mechanisms in Patients With Fibromyalgia Recruiting Fibromyalgia|Pain NCT03464292
Capsaicin Cough Threshold in Chronic Cough Due to Postnasal Drip Completed Post Nasal Drip NCT00588627
Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical Capsaicin in the Treatment of Patients With Myofascial Pain Syndrome of the Upper Trapezius: A Pilot Study Completed Myofascial Pain Syndrome of the Upper Trapezius NCT01884116
Intranasal Capsaicinoid Spray Recruiting Tolerance|Capsaicin|Rhinitis NCT03952845
Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed Interstitial Cystitis|Vulvar Diseases NCT00004316
Neurogenic Mechanisms in Burning Mouth Syndrome Completed Burning Mouth Syndrome NCT00875537
Topical Use of 20% Beta Caryophyllene Alone And In Combination With 0.025% Capsaicin for Pain Caused by Osteoarthritis Of The Knee Completed Pain NCT03152578
The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee Completed Osteoarthritis, Knee NCT03472677
Assessment of Dystussia in Traumatic Brain Injury Completed TBI|Brain Injury NCT02240329
Sensory Neuromodulation Protocol for the Treatment of Post-stroke Oropharyngeal Dysphagia. Completed Swallowing Disorder|Dysphagia|Stroke|Neurophysiologic Abnormality NCT04052178
Safety, Tolerability and Pharmacokinetics of Multiple Doses of AV-101 in Healthy Volunteers Completed Neuropathic Pain NCT01483846
Autofluorescent Flavoprotein Imaging of Intraepidermal Nerve Fibers: a Pilot Study Completed Small Fiber Neuropathy NCT02537951
Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients Recruiting Cough NCT03722849
Remote Ischemic Preconditioning Mechanism Study Completed Pain NCT01541436
A Study to Investigate the Effect of SB-705498 on Chronic Cough Completed Rhinitis NCT01476098
ToAST:Investigating the Effect of Bronchial Thermoplasty on Cough in Patients With Severe Asthma Unknown status Asthma Chronic, Cough NCT03281941
Capsaicinoid Ingestion, Human Metabolism and Exercise Unknown status Metabolism NCT02139852
OA Knee Pain Relief Study of 0.25% 920-CGS-200 Completed Osteoarthritis, Knee NCT03124407
Experimental Biomarker Study for Pain Thresholds Completed Pain NCT02695745
The Effects of Tiotropium on the Cough Reflex in Patients With Chronic Obstructive Pulmonary Disease (COPD) Completed Chronic Obstructive Pulmonary Disease|Chronic Bronchitis NCT00870896
Localized Neuropathic Pain: Topical Treatment Versus Systemic Treatment Recruiting Neuropathic Pain NCT03348735
Evaluation of the Antihyperalgesic Effect of Tapentadol in Two Human Experimental Models Terminated Pain|Hyperalgesia|Allodynia NCT01615510
Capsaicinoid Ingestion, Human Metabolism and Exercise (Phase 2) Unknown status Metabolism|Exercise NCT02138630
Pain Biomarker Study Active, not recruiting Migraine|Cluster Headache|Trigeminal Autonomic Cephalgia|Hemicrania Continua|Paroxysmal Hemicrania|SUNCT|Short-Lasting Unilateral Neuralgiform Headache With Conjunctival Injection and Tearing NCT03511846
Study of NGX-1998 for the Treatment of Postherpetic Neuralgia Completed Postherpetic Neuralgia|Pain NCT01228838
Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis Unknown status Allergic Rhinitis NCT00825656
Study of Endogenous Inhibitory Modulation During Gastric and Somatic Stimulation Completed Functional Dyspepsia NCT00693407
Functional Brain Imaging of Pain Phenotype and Genotype Completed Pain NCT01777087
Effect of Muscular Exercise on Cough Reflex Completed Cough NCT02882555
An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain Terminated Herpes Zoster|Neuralgia|Pain|HIV Infections|Peripheral Nervous System Diseases|Diabetic Neuropathies|Diabetes Mellitus|Polyneuropathies NCT00089557
Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy Terminated HIV Infections|Peripheral Nervous System Diseases|Pain NCT00085761
Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy Completed HIV Infections|Peripheral Nervous System Diseases|Pain NCT00064623
NGX-4010 for the Treatment of Postherpetic Neuralgia Completed Herpes Zoster|Neuralgia|Pain|Peripheral Nervous System Diseases|Shingles NCT00061776
Salivary Interactions With Chemosensations Recruiting Diet, Food Choice, Taste NCT03883880
Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease Completed Cough|Parkinson's Disease NCT02183519
Cannabinoid Modulation of Pain Active, not recruiting Pain NCT01595620
Study to Evaluate the Safety and Tolerability of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed Morton's Neuroma NCT02550756
Normal Breathing and Swallowing in Healthy Volunteers Completed Healthy NCT03122145
The Acute Effects of Capsiate During Exercise Completed Healthy NCT00692601
Study of NGX-4010 With the Use of Open Label Lidocaine (2.5%)/Prilocaine (2.5%) Cream for the Treatment of Postherpetic Neuralgia (PHN) Completed Postherpetic Neuralgia NCT00916942
Cough According to Stimulus Type in PD Completed Parkinson's Disease NCT02390089
Effect of Spinal Ketorolac After Acute Opioid Exposure Terminated Healthy NCT00693160
Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy Completed Pain|HIV Infections|Peripheral Nervous System Diseases NCT00321672
Capsimax Effect on Metabolic Rate, Satiety and Food Intake Completed Energy Metabolism|Eating|Hunger NCT03489226
Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo Completed Cough Reflex Sensitivity NCT02062710
Positron Emission Tomography to Measure Pain and Pain Control Completed Healthy|Hyperalgesia|Pain|Peripheral Nervous System Disease NCT00001307
A Study of LY3316531 in Healthy Participants Completed Healthy NCT03611608
Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy (HIV-AN) or Postherpetic Neuralgia (PHN) Completed Herpes Zoster|Neuralgia|Pain|HIV Infections|Peripheral Nervous System Diseases NCT00233155
A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain Active, not recruiting Osteoarthritis, Knee NCT03660943
Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia Completed Herpes Zoster|Neuralgia|Pain|Peripheral Nervous System Diseases NCT00068081
Transient Receptor Potential Vanilloid One (TRPV1) Receptor Expression in Children With Retrosternal Pain Completed Epigastric Pain|Retrosternal Pain|Esophagitis|Gastrointestinal Symptoms NCT00677378
Reduction in Pain Intensity Following IV or Oral Pain-relieving Products Completed Pain NCT02678416
A Clinical Study to Test Efficacy and Safety of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain Completed Osteo Arthritis Knee NCT03429049
Tolerability of Three Local Anesthetic Formulations in Conjunction With NGX-4010 for the Treatment of Neuropathic Pain Completed Herpes Zoster|Neuralgia|Pain|HIV Infections|Peripheral Nervous System Diseases|Diabetic Neuropathies|Diabetes Mellitus|Polyneuropathies NCT00082316
The Neurobiology of Expectancy and Pain Perception Completed Pain NCT01575106
To Study the Peripheral Effect of Botulinum Toxin-A (Botox-A) on Experimentally Induced Cutaneous Pain in Healthy Subjects Completed Healthy NCT00435682
Airway Protective Mechanisms in PD (R01) Recruiting Parkinson Disease NCT03321019
Accurate Screening Tools for Dysphagia in Amyotrophic Lateral Sclerosis (ALS) Completed Amyotrophic Lateral Sclerosis NCT02710162
Study of the Efficacy and Safety of SCH 486757 in Subjects With Chronic Cough (Study P04887) Completed Cough NCT00506987
Study of the Efficacy and Safety of SCH 619734 in Subjects With Chronic Cough From an Unknown Cause (Study P04888) Completed Cough NCT00506545
GSK2339345 Hypertussive Challenge Study Completed Cough NCT01899768
Ascending Single Doses of Erenumab (AMG 334) in Healthy Adults and Migraine Patients Completed Migraine NCT01688739
A Study to Compare Five Different Treatment Regimens of CNTX-4975 for Participants With Chronic, Moderate-to-Severe Osteoarthritis Pain Active, not recruiting Knee Osteoarthritis NCT03661996
Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS) Completed Amyotrophic Lateral Sclerosis NCT02710110
Efficacy and Safety Study of 4975 in Patients Undergoing Total Hip Replacement Terminated Arthroplasty NCT00683267
Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity Completed Refractory Chronic Cough NCT02397460
Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014) Completed Refractory Chronic Cough NCT02476890
Effect of Rufinamide on Chronic Postthoracotomy Pain Syndrome Withdrawn Peripheral Nerve Injuries|Pain NCT02095899
Design of a Model to Study Functionality of the Trigeminal Nerve in Relation to Controlled Nasal Fractures Unknown status Fracture of Nasal Bones, Sequela NCT02733783
Transdermal Delivery of Glucosamine to the Synovial Fluid of Male and Female With Knee Osteoarthritis Completed Osteoarthritis, Knee NCT03743896
Efficacy of Spinal Oxytocin in Healthy Volunteers Recruiting Healthy Volunteer Study NCT01996605
Effect of Nalbuphine and Naloxone on Experimentally Induced Skin Sensitivity Terminated Healthy NCT00947284
Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration Not yet recruiting Small Fiber Neuropathy NCT03912220
Efficacy and Safety of ALGRX 4975 in the Treatment of Postoperative Pain After Gall Bladder Removal Completed Postoperative Pain NCT00133133
Cough and Swallow Rehab Following Stroke Completed Ischemic Stroke NCT01907321
Efficacy and Safety of ALGRX 4975 in Treatment of Postoperative Pain After Hernia Repair Completed Postoperative Pain NCT00146198
Effect of NGX-4010 on ENFD and Sensory Function Completed Human Volunteers NCT00254449
Safety and Tolerability of 4975 in Patients Undergoing Arthroscopic Surgery to Repair the Rotator Cuff of the Shoulder Terminated Rotator Cuff Repair of the Shoulder NCT00672568
Effect of Afferent Oropharyngeal Pharmacological and Electrical Stimulation on Swallow Response and on Activation of Human Cortex in Stroke Patients With Oropharyngeal Dysphagia Completed Dysphagia|Aspiration|Stroke NCT01777672
Cough Sensitivity and Taste Preferences Completed Smoking NCT01399060
Assessment of Peripheral GABA Receptors for Local Pain Relief Unknown status Pain NCT02928328
Ascending Multiple-Doses of Erenumab (AMG 334) in Healthy Adults and in Migraine Patients Completed Migraine NCT01723514
Effectiveness of Two Different Doses of BI 1026706 on the Overall Peak-to-Peak (PtP) N2/P2-component Amplitude of Laser (Somatosensory, Radiant-heat) Evoked Potentials (LEP) in UVB(Ultraviolet)-Irradiated Skin in Healthy Male Volunteers Completed Healthy NCT02037165
Effect of Electronic Cigarette Use on Cough Reflex Sensitivity Completed Cough NCT02203162
A Study of the Effect of 20 mg Ambroxol Hydrochloride on Acute Cough. Completed Cough NCT03415269
Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls Completed Odontalgia NCT00115102
Effect of Cyclodextrin on Sensory Nerve Activity: A Novel Anti-tussive Therapy Withdrawn Cough NCT01960621
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer Recruiting Intractable Pain|Palliative Care NCT00804154
NEO6860, a TRPV1 Antagonist, First in Human Study Completed Osteoarthritis, Knee NCT02337543
B181 Metobes-III: Weight Loss Maintenance of a New Bioactive Compound (Metobes-Long) Completed Obesity NCT00302263
Endogenous Pain Facilitation and Inhibition in Postpartum Women Completed Pain Inhibition and Facilitation in Post Partum Women NCT01843517
ALGRX 4975 in the Treatment of Patients With Morton's Neuroma Completed Neuroma NCT00130962
Efficacy and Safety of a Nutraceutical Supplement With Standardized Botanicals in Peri-menopausal and Menopausal Women With Thinning Hair Recruiting Hair Thinning NCT04048031
Investigation of Topical SB705498 on Healthy Volunteers Completed Dermatitis, Atopic NCT01673529
Functional Dyspepsia and Symptom Perception Unknown status Dyspepsia NCT02522000
Conjoint Analysis of Treatment Preferences for Osteoarthritis Completed Osteoarthritis NCT01003925
Effects of Heating Massaging Vibrating Vicinity of the Insulin Delivery Site Unknown status DIABETES NCT01307514
Delineating Swallowing Impairment and Decline in ALS Recruiting Amyotrophic Lateral Sclerosis NCT02962050
Efficacy of Co-administration of an NSAID With a Dopamine Agonist In Healthy Subjects Withdrawn Acute Pain NCT02116790
A Safety Tolerance and Experimental Hyperalgesia Study of Oral NGX426 in Healthy Male Voluneteers Completed Healthy|Hyperalgesia NCT00832546
Effects of GABA-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers Completed Pain NCT01011036
The Alcohol-Pain Connection: Mechanisms and Genetic/Psychological Correlates Recruiting Pain|Alcohol Drinking|Acute Pain|Drinking Behavior NCT03311594
Efficacy of DNK333 in Patients With COPD and Cough Completed Chronic Obstructive Pulmonary Disease NCT01287325
Cough Responses to Tussive Agents in Health and Disease Completed Chronic Obstructive Airway Disease|Asthma|Chronic Cough NCT01297790
A Study to Assess the Efficacy of XEN-D0501 in Reducing the Cough Frequency in Patients With Chronic Idiopathic Cough Completed Chronic Idiopathic Cough NCT02233699
A Study to Assess the Efficacy of XEN-D0501 in Reducing the Cough Frequency in Patients With COPD Completed Chronic Obstructive Pulmonary Disease NCT02233686
Dose-effect of SSR180575 in Diabetic Neuropathy Completed Diabetic Neuropathies NCT00502515
Physiologic Effect of Spices Ingestion Completed Healthy NCT02193438
Mannitol Cream for Post Herpetic Neuralgia Completed Neuralgia, Postherpetic NCT02484170
Effect of Valdecoxib Pretreatment on Pain and Secondary Hyperalgesia in Healthy Volunteers Completed Pain|Hyperalgesia NCT00260325
Modulatory Effects of Multichannel tDCS During Prolonged Experimental Pain Active, not recruiting Prolonged Pain|Neuroplasticity|Brain Modulation NCT04165980
The Effect of Physical Exercise in a Cold Air Environment on Normal Volunteers and Asthmatic Patients Enrolling by invitation Asthma, Exercise-Induced NCT03840044
QST and Neuropathic Pain Recruiting Chronic Pain NCT03806010
A Phase II Clinical Study of PDC-748 in Patients With Acute Cough Completed Acute Cough NCT00547846
The Effects of Topical Treatment With Clonidine + Pentoxifylline in Patients With Neuropathic Pain Recruiting Neuralgia Peripheral NCT03342950
The Effect of Caffeine on Acupuncture Analgesia With the Human Pain Model Completed Pain NCT02577770
Study of NGX-4010 for the Treatment of Postherpetic Neuralgia Completed Peripheral Nervous System Diseases|Pain|Neuralgia|Herpes Zoster|Shingles NCT00300222
Pregabalin Versus Pulsed Radiofrequency Ablation for Treatment of Chronic Post-thoracotomy Pain Enrolling by invitation Chronic Post-thoracotomy Pain NCT03942796
Study of NGX-4010 for the Treatment of Postherpetic Neuralgia Completed Peripheral Nervous System Diseases|Pain|Neuralgia|Herpes Zoster|Shingles NCT00115310
Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome Completed Chronic Fatigue Syndrome|Fibromyalgia|Gulf War Illness|Multiple Chemical Sensitivity|Interstitial Cystitis|Irritable Bowel Syndrome NCT00810329
Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Intraoperative Administration of CA-008 for the Correction of Hallux Valgus Deformity Completed Hallux Valgus Deformity NCT03307837
The Analgesic Activity of a Topical Formulation in Patients With Osteoarthritis of the Hands Unknown status Osteoarthritis of the Hands NCT02485145
Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed Prurigo Nodularis NCT00507832
Two Supplemented Against Skin Reactivity Completed Skin Sensitivity|Trans-epidermal Water Loss|Clinical Score|Assessment of Skin Moisturization Factors|Assessment of Serum Immune-regulatory Cytokine|Evaluation of Intestinal Flora Composition NCT01368224
Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain Not yet recruiting Intractable Pain|Palliative Care NCT02522611
Neuropeptide Y (NPY) Regulation of Nociceptors Completed Pain NCT00596193
ALGRX 4975 in the Treatment of Tennis Elbow Completed Tennis Elbow NCT00130949
The Safety, Tolerability, PK and PD of GSK2339345 in Healthy Subjects Completed Cough NCT01494636
Sb-705498 Rectal Pain Study Terminated Irritable Colon NCT00461682
Prospective Analgesic Compound Efficacy (PACE) Study Completed Arthritis|Tendonitis|Gout|Radiculopathy|Muscle Spasms|Synovitis|Migraine|Headache NCT02403687
An fMRI Study in Healthy Volunteers to Investigate the Effects of ABX-1431 on Experimental Hyperalgesia and Its Neural Correlates Completed Pain NCT02929264
Mechanisms of Sleep Disruption Hyperalgesia Completed Sleep Deprivation|Pain NCT01794689
Study of the Safety and Effectiveness of BC1036 Capsules to Treat Frequent Long-Term Cough Completed Cough NCT01656668
Civamide Nasal Solution for the Treatment of Dry Eye Completed Dry Eye NCT02116244
Civamide Nasal Solution for Postherpetic Neuralgia of the Trigeminal Nerve Terminated Postherpetic Neuralgia NCT01886313
Effect of Dihydrocapsiate on Energy Expenditure in Women Completed Obesity NCT01773356
Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis With a High Protein Very Low Calorie Diet Completed Healthy NCT01142687
Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate Completed Obesity|Weight NCT00999297
Evaluating the Safety and Efficacy Civamide in Osteoarthritis (OA) of the Knee(s) Completed Osteoarthritis of the Knee NCT00995306
Evaluation of Civamide Patch in Treatment of Postherpetic Neuralgia and Post-Incisional Neuralgia Completed Postherpetic Neuralgia NCT00845923
Oral Civamide Safety, Tolerability First in Human Study Terminated Healthy NCT00802217
Civamide Patch Safety, Tolerability and PK Study Completed Healthy Volunteers NCT00758433
Civamide in OA of the Knee(s) Completed Osteoarthritis, Knee NCT00077935
A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache Completed Episodic Cluster Headache NCT00033839
Efficacy of Two Interventions Increasing Sensory Stimulus in Elderly Patients With Oropharyngeal Dysphagia Completed Dysphagia NCT01762228
The Effects of Capsinoids on Brown Adipose Tissue Activation in Obesity Recruiting Weight Loss NCT03110809
Efficacy and Safety of a Nutraceutical Supplement With Standardized Botanicals in Women With Thinning Hair Completed Hair Thinning NCT03206567
Speech Therapy in the Management of Chronic Cough Recruiting Cough|Speech Therapy NCT03457610
Civamide Nasal Solution for Cluster Headache Not yet recruiting Episodic Cluster Headache NCT01341548
Intranasal Civamide for Episodic Cluster Headache Completed Episodic Cluster Headache NCT00069082
Pathogenetic Mechanisms of Chronic Obstructive Pulmonary Diseases Completed COPD|Asthma NCT01378039
Novel Endpoints in Cough Challenge Testing Completed Chronic Obstructive Pulmonary Disease|Asthma|Healthy|Chronic Cough|Smokers NCT01566968
Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers Completed Healthy Volunteers NCT00152724
Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy Completed Alcohol Drinking NCT00699556
ALGRX 4975 After Total Knee Replacement Completed Arthroplasty, Replacement, Knee|Knee Injuries NCT00132392
The Effect of Bariatric Surgery on Peripheral Nerve Function and Axonal Regeneration Completed Peripheral Neuropathy|Obesity NCT02218866
Indomethacin for Refractory Chronic Cough Recruiting Refractory Chronic Cough NCT03662269
Efficacy and Safety of Finalgon® Cream Multiple Doses in Acute Low Back Pain Completed Low Back Pain NCT02300311
Nonivamide/Nicoboxil Ointment in Acute Low Back Pain Completed Acute Low Back Pain NCT01708915
Intensive Insulin Treatment and Ischemic Foot Ulcer Completed Ischemic Foot Ulcer NCT01957930
Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response Not yet recruiting Chronic Low Back Pain NCT04142177
Evaluation of the Efficacy and Tolerability of ABO/MEG-B-09 in Children With Acute Cough Completed Cough NCT01259674
Physical Health in Midlife: Influences of Adversity and Relationships Over Time Completed Cardiovascular Disease|Type 2 Diabetes NCT01853332
Weight Loss Maintenance of a New Bioactive Compound (Metobes-Long) Completed Obesity NCT00302276
Analgesic Effect of Oxytocin Receptor Modulation Completed Pain|Hyperalgesia|Central Sensitization NCT01918475
NEP-TUNE: Neuropathic Pain - Treatment With Pregabalin Under Real-life Conditions in Denmark Completed Peripheral Neuropathic Pain NCT01524796
Pulsed Electromagnetic Fields for Multiple Chemical Sensitivity Completed Multiple Chemical Sensitivity NCT01834781
P38 Mitogen-activated Protein (Map) Kinase Inhibitor (SB-681323)Study In Patients With Neuropathic Pain Completed Pain, Neuropathic NCT00390845
Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? Unknown status Fibromyalgia NCT02806440

References

Publication DOI Pubmed PMCID
Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress. Biochemical and biophysical research communications Hyun Kyoung Lee, In Ae Seo, Yoon Kyung Shin, Ji Wook Park, Duk Joon Suh, Hwan Tae Park, 382, 2, 2009-05-01, 2009-03-13, 10.1016/j.bbrc.2009.03.046 10.1016/j.bbrc.2009.03.046 19285962 19285962
Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. Clinical cancer research : an official journal of the American Association for Cancer Research Manisha Bhutani, Ashutosh K Pathak, Asha S Nair, Ajaikumar B Kunnumakkara, Sushovan Guha, Gautam Sethi, Bharat B Aggarwal, 13, 10, 2007-05-15, None, 10.1158/1078-0432.CCR-06-2575 10.1158/1078-0432.CCR-06-2575 17505005 17505005
Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells. Free radical research Xun Chen, Miduo Tan, Zhiqin Xie, Bin Feng, Zhijian Zhao, Kaiqing Yang, Chen Hu, Ni Liao, Taoli Wang, Dongliang Chen, Feng Xie, Caixi Tang, 50, 7, None, 2016-04-25, 10.3109/10715762.2016.1173689 10.3109/10715762.2016.1173689 27043357 27043357
Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling. Acta pharmacologica Sinica Su-Shan Zhang, Yu-Hao Ni, Chen-Ru Zhao, Zhen Qiao, Hong-Xia Yu, Lu-Yao Wang, Jin-Yan Sun, Chen Du, Jia-Hao Zhang, Li-Ying Dong, KeWei Wang, Jian-Jun Gao, 39, 3, None, 2017-11-30, 10.1038/aps.2017.156 10.1038/aps.2017.156 29188798 PMC5843835

Vendors

Company Lnk to product
MERCK (Sigma Aldrich) https://www.sigmaaldrich.com/catalog/product/SIGMA/M2028?lang=pl&region=PL&gclid=Cj0KCQiAs67yBRC7ARIsAF49CdVqm9Dac5v2IUAMwVgrkho0VhG6BoxNpt9DDIYGZMAz7bQQXvcM4KkaAoe1EALw_wcB
Selleckchem https://www.selleckchem.com/products/capsaicin.html
Key Organics https://www.keyorganics.net/capsaicin-mfcd00017259-404-86-4-c18h27no3.html
Tocris https://www.tocris.com/products/e-capsaicin_0462
Caymanchemical https://www.caymanchem.com/product/92350/capsaicin
MedChemExpress https://www.medchemexpress.com/Capsaicin.html
AK Scientific Inc. https://aksci.com/item_detail.php?cat=I542
ANAWA https://www.anawa.ch/other-products-186/capsaicin-404-86-4-231004189.html
Fluorochem http://fluorochem.co.uk/Products/Product?code=M01481

Filter data

Compound Capsaicin
Experiment types 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, Caspase-3 activity , CellEvent Caspase-3/7 Green Detection Reagent, DCFH-DA, ELISA, EMSA, Flow cytometry , Immunocytochemistry, Immunofluorescence, Live/Dead assay, MTT Assay , RT-PCR, Tumor volume, weight, Western Blot
Concentrations 1.00, 10.00, 100.00, 150.00, 200.00, 25.00, 250.00, 5.00, 50.00, N/A
Cell lines HL-7702, HepG2, Huh7, MM1.S, PLC/PRF/5, PLC/PRF/5 (xenograft), RT4, U266
Organisms Homo sapiens, Mus musculus, Rattus norvegicus
Animal models
STAT proteins STAT3, p-STAT3, p-STAT3 (Tyr-705)
Other Bax, Bcl-2, Bcl-xL, Becilin 1, Caspase 3, Cleaved PARP, Cleaved caspase 3, Cleaved-PARP, Cyclin D1, ERK1/2, ErbB2, GADD, GAPDH, JAK1, LC3I, LC3II, PARP, Src, Survivin, TRPV1, Tubulin, VEGF, gp130, p-ERK1/2, p-JAK1, p62, pSrc, peIF2a, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Capsaicin MTT Assay Influence on cell viability 1.00 µM RT4 Rattus norvegicus
Capsaicin MTT Assay Influence on cell viability 10.00 µM RT4 Rattus norvegicus
Capsaicin MTT Assay Influence on cell viability 50.00 µM RT4 Rattus norvegicus
Capsaicin MTT Assay Influence on cell viability 100.00 µM RT4 Rattus norvegicus
Capsaicin MTT Assay Influence on cell viability 200.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 1.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 10.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 50.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 200.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on cell surace proteinc 100.00 µM RT4 Rattus norvegicus
Capsaicin RT-PCR Influence on gene expression 100.00 µM RT4 Rattus norvegicus
Capsaicin RT-PCR Influence on gene expression 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity in presence of CHX 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity in presence of CHX 100.00 µM RT4 Rattus norvegicus STAT3
Capsaicin Western Blot Influence on protein activity in presence of CHX 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity in presence of IL-6 100.00 µM RT4 Rattus norvegicus p-STAT3
Capsaicin Western Blot Influence on protein activity in presence of IL-6 100.00 µM RT4 Rattus norvegicus STAT3
Capsaicin Western Blot Influence on protein activity in presence of IL-6 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity in presence of IL-6 and CHX 100.00 µM RT4 Rattus norvegicus p-STAT3
Capsaicin Western Blot Influence on protein activity in presence of IL-6 and CHX 100.00 µM RT4 Rattus norvegicus STAT3
Capsaicin Western Blot Influence on protein activity in presence of IL-6 and CHX 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity in presence of IL-6 and CHX 100.00 µM RT4 Rattus norvegicus
Capsaicin Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence on protein activity 5.00 µM U266 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence on protein activity 10.00 µM U266 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence on protein activity 25.00 µM U266 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence on protein activity 50.00 µM U266 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens STAT3
Capsaicin Western Blot Influence on protein activity 5.00 µM U266 Homo sapiens STAT3
Capsaicin Western Blot Influence on protein activity 10.00 µM U266 Homo sapiens STAT3
Capsaicin Western Blot Influence on protein activity 25.00 µM U266 Homo sapiens STAT3
Capsaicin Western Blot Influence on protein activity 50.00 µM U266 Homo sapiens STAT3
Capsaicin EMSA Influence on protien binding to DNA 1.00 µM U266 Homo sapiens STAT3
Capsaicin EMSA Influence on protien binding to DNA 5.00 µM U266 Homo sapiens STAT3
Capsaicin EMSA Influence on protien binding to DNA 10.00 µM U266 Homo sapiens STAT3
Capsaicin EMSA Influence on protien binding to DNA 25.00 µM U266 Homo sapiens STAT3
Capsaicin EMSA Influence on protien binding to DNA 50.00 µM U266 Homo sapiens STAT3
Capsaicin Immunocytochemistry Influence on protein translocation 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on protein activity in presence of IL-6 50.00 µM MM1.S Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence on protein activity in presence of IL-6 50.00 µM MM1.S Homo sapiens STAT3
Capsaicin Western Blot Influence on protein activity in presence of IL-6 50.00 µM U266 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence on protein activity in presence of IL-6 50.00 µM U266 Homo sapiens STAT3
Capsaicin Western Blot Influence on protein activity 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on protein activity 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on protein activity 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on protein activity 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on protein activity 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on protein activity 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on gene expression 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on gene expression 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on gene expression 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on gene expression 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on gene expression 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on gene expression 50.00 µM U266 Homo sapiens
Capsaicin 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay Influence on cell proliferation 5.00 µM U266 Homo sapiens
Capsaicin 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay Influence on cell proliferation 50.00 µM U266 Homo sapiens
Capsaicin Flow cytometry Influence on cell cycle 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on cell proliferation 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on cell proliferation 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on cell proliferation 50.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on cell proliferation 50.00 µM U266 Homo sapiens
Capsaicin Live/Dead assay Influence on cell apoptosis 25.00 µM U266 Homo sapiens
Capsaicin Western Blot Influence on protein activity in precence of thalidomide 25.00 µM U266 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence on protein activity in precence of valcade 25.00 µM U266 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence on protein activity in precence of thalidomide 25.00 µM U266 Homo sapiens STAT3
Capsaicin Western Blot Influence on protein activity in precence of valcade 25.00 µM U266 Homo sapiens STAT3
Capsaicin Flow cytometry Influence on cell apoptosis 50.00 µM HepG2 Homo sapiens
Capsaicin Flow cytometry Influence on cell apoptosis 100.00 µM HepG2 Homo sapiens
Capsaicin Flow cytometry Influence on cell apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Caspase-3 activity Influence on cell apoptosis 50.00 µM HepG2 Homo sapiens
Capsaicin Caspase-3 activity Influence on cell apoptosis 100.00 µM HepG2 Homo sapiens
Capsaicin Caspase-3 activity Influence on cell apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Immunofluorescence Influence on cell autophagy 50.00 µM HepG2 Homo sapiens
Capsaicin Immunofluorescence Influence on cell autophagy 100.00 µM HepG2 Homo sapiens
Capsaicin Immunofluorescence Influence on cell autophagy 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on cell autophagy 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of autophagy of capsaicin induced apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of autophagy of capsaicin induced apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of autophagy of capsaicin induced apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of autophagy of capsaicin induced apoptosis 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy 50.00 µM HepG2 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy 100.00 µM HepG2 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy 200.00 µM HepG2 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy 50.00 µM HepG2 Homo sapiens STAT3
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy 100.00 µM HepG2 Homo sapiens STAT3
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy 200.00 µM HepG2 Homo sapiens STAT3
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy 50.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy 100.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy (siSTAT3) 200.00 µM HepG2 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy (siSTAT3) 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy (siSTAT3) 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy (siSTAT3) 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy (siSTAT3) 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy (siSTAT3) 200.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence of STAT3 in capsaicin induced autophagy (siSTAT3) 200.00 µM HepG2 Homo sapiens
Capsaicin DCFH-DA Influence on ROS 200.00 µM HepG2 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 50.00 µM PLC/PRF/5 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 100.00 µM PLC/PRF/5 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 150.00 µM PLC/PRF/5 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 200.00 µM PLC/PRF/5 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 250.00 µM PLC/PRF/5 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 50.00 µM Huh7 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 100.00 µM Huh7 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 150.00 µM Huh7 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 200.00 µM Huh7 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 250.00 µM Huh7 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 50.00 µM HepG2 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 100.00 µM HepG2 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 150.00 µM HepG2 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 200.00 µM HepG2 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability 250.00 µM HepG2 Homo sapiens
Capsaicin Western Blot Influence on tumor cell viability N/A N/A PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Influence on tumor cell viability N/A N/A Huh7 Homo sapiens
Capsaicin Western Blot Influence on tumor cell viability N/A N/A HepG2 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability i presence of NAC 200.00 µM PLC/PRF/5 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 10.00 µM PLC/PRF/5 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 50.00 µM PLC/PRF/5 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 100.00 µM PLC/PRF/5 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 10.00 µM Huh7 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 50.00 µM Huh7 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 100.00 µM Huh7 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 10.00 µM HepG2 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 50.00 µM HepG2 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 100.00 µM HepG2 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 10.00 µM HL-7702 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 50.00 µM HL-7702 Homo sapiens
Capsaicin MTT Assay Influence on tumor cell viability in presence of Sorafenib 100.00 µM HL-7702 Homo sapiens
Capsaicin ELISA Influence on tumor cell apoptosis in presence of Sorafenib 100.00 µM PLC/PRF/5 Homo sapiens
Capsaicin CellEvent Caspase-3/7 Green Detection Reagent Influence on pro-apoptotic protein expression 100.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Influence on pro-apoptotic protein expression 100.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Influence on pro-apoptotic protein expression 100.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Influence on pro-apoptotic protein expression 100.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 10.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 50.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 100.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 150.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 200.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 10.00 µM PLC/PRF/5 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Antitumor properties 50.00 µM PLC/PRF/5 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Antitumor properties 100.00 µM PLC/PRF/5 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Antitumor properties 150.00 µM PLC/PRF/5 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Antitumor properties 200.00 µM PLC/PRF/5 Homo sapiens p-STAT3 (Tyr-705)
Capsaicin Western Blot Antitumor properties 10.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 50.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 100.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 150.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Western Blot Antitumor properties 200.00 µM PLC/PRF/5 Homo sapiens
Capsaicin Tumor volume, weight Influence on tumor growth 200.00 µM PLC/PRF/5 (xenograft) Mus musculus
Capsaicin Tumor volume, weight Influence on tumor growth 100.00 µM PLC/PRF/5 (xenograft) Mus musculus