C188-9

Name Value
Weight 471.534 g/mol
Zinc ID ZINC1154831
Smiles COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)C4=C(C=CC5=CC=CC=C54)O
Molecular formula C27H21NO5S
Mode of inhibition Direct STAT
CAS 432001-19-9

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget Uddalak Bharadwaj, T Kris Eckols, Xuejun Xu, Moses M Kasembeli, Yunyun Chen, Makoto Adachi, Yongcheng Song, Qianxing Mo, Stephen Y Lai, David J Tweardy, 7, 18, 2016-05-03, None, 10.18632/oncotarget.8368. 10.18632/oncotarget.8368. 27027445 PMC5041982
C188-9, a small-molecule STAT3 inhibitor, exerts an antitumor effect on head and neck squamous cell carcinoma. Anti-cancer drugs Jian-Xin Di, Hong-Yan Zhang, 30, 8, None, None, 10.1097/CAD.0000000000000783 10.1097/CAD.0000000000000783 30870229 30870229
STAT3 Contributes To Oncolytic Newcastle Disease Virus-Induced Immunogenic Cell Death in Melanoma Cells 10.3389/fonc.2019.00436 https://www.ncbi.nlm.nih.gov/pubmed/31192135 N/A
STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model. Allergy A C Gavino, K Nahmod, U Bharadwaj, G Makedonas, D J Tweardy, 71, 12, None, 2016-06-23, 10.1111/all.12937 10.1111/all.12937 27225906 27225906
Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands) Katherine M Lewis, Uddalak Bharadwaj, T Kris Eckols, Mikhail Kolosov, Moses M Kasembeli, Colleen Fridley, Ricardo Siller, David J Tweardy, 90, 2, None, 2015-09-15, 10.1016/j.lungcan.2015.09.014 10.1016/j.lungcan.2015.09.014 26410177 PMC4619129

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/c188-9.html
MERCK (Sigma Aldrich) https://www.sigmaaldrich.com/catalog/product/mm/573128?lang=pl&region=PL
BioVision https://www.biovision.com/stat3-inhibitor-c188-142.html
MedChemExpress https://www.medchemexpress.com/C188-9.html
TargetMol https://www.targetmol.com/compound/C188-9
Frontier Scientific Services https://orders.frontierssi.com/fssionline32/public/product.aspx?cat=100081376&type=hts
AK Scientific Inc. https://aksci.com/item_detail.php?cat=Y0002
AK Scientific Inc. https://aksci.com/item_detail.php?cat=J10967
1PlusChem https://www.1pchem.com/prod/88191-48-4
1PlusChem https://www.1pchem.com/prod/7295-85-4
Matrix Scientific http://www.matrixscientific.com/098363.html
AmBeed https://www.ambeed.com/products/13392-26-2.html
PiChemicals http://www.pipharm.com/catalog_products/PI-41475.html
Specs https://www.specs.net/index.php?page=search_show_structure&structureId=AE-765/20006021&guest=Y&message=GUEST%20user%20view...
TargetMol https://www.targetmol.com/compound/%28+%29-Catechin-Hydrate
TargetMol https://www.targetmol.com/compound/Catechin
Ambinter http://www.ambinter.com/reference/Amb22169908
Ambinter http://www.ambinter.com/reference/Amb22467753
Ambinter http://www.ambinter.com/reference/Amb2747278
Ambinter http://www.ambinter.com/reference/Amb540975
Ambinter http://www.ambinter.com/reference/Amb6350547
Mcule https://mcule.com/MCULE-4219942050/
MolCore https://www.molcore.com/product/490-46-0
BLDpharm https://www.bldpharm.com/products/13392-26-2.html
BLDpharm https://www.bldpharm.com/products/35323-91-2.html

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
C188-9 Structure Activity Realtionship SAR Structure comparision N/A N/A
C188-9 SPR Biacore sensorchip-immobilized phosphododecapeptide ligand N/A µM Homo sapiens STAT3
C188-9 Phosphoflow Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 30.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 300.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 30.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 300.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Mean fluorescence Influence on proteins activity N/A N/A Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Mean fluorescence Influence on proteins activity N/A N/A Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 0.10 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 0.30 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 0.10 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 0.30 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 0.10 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 0.30 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 1.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 3.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 10.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 100.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 0.10 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 0.30 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 1.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 3.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 10.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 100.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 MTT Influence on cell viability and proliferation 0.10 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.30 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 1.00 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 3.00 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 10.00 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 100.00 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.10 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.30 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 1.00 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 3.00 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 10.00 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 100.00 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.10 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.30 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 1.00 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 3.00 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 10.00 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 100.00 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.10 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.30 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 1.00 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 3.00 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 10.00 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 100.00 µM HN30 Homo sapiens
C188-9 Tumor volume Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude STAT3
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude p-STAT1 (Tyr-701)
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude STAT1
C188-9 Western Blot Level of STAT3 estimation N/A N/A Hep-2 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A Hep-2 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A Hep-2 Homo sapiens
C188-9 Western Blot Level of STAT3 estimation N/A N/A CAL27 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A CAL27 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A CAL27 Homo sapiens
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC9 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC9 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC9 Homo sapiens
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC15 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC15 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC25 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC25 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens STAT1
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens STAT3
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens STAT1
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens STAT3
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on nuclear translocation N/A N/A SCC15 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on nuclear translocation N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on nuclear translocation N/A N/A SCC25 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on nuclear translocation N/A N/A SCC25 Homo sapiens
C188-9 Luciferase activity Influence on transcriptional activity N/A N/A SCC15 Homo sapiens STAT3
C188-9 Luciferase activity Influence on transcriptional activity N/A N/A SCC25 Homo sapiens STAT3
C188-9 Colony formation assay Influence on cell proliferation N/A N/A SCC15 Homo sapiens
C188-9 Colony formation assay Influence on cell proliferation N/A N/A SCC25 Homo sapiens
C188-9 MTT Influence on cell proliferation N/A N/A SCC15 Homo sapiens
C188-9 MTT Influence on cell proliferation N/A N/A SCC25 Homo sapiens
C188-9 Cell cycle analysis Influence on cell proliferation N/A N/A SCC15 Homo sapiens
C188-9 Cell cycle analysis Influence on cell proliferation N/A N/A SCC25 Homo sapiens
C188-9 Flow cytometry Influence on cell apoptosis N/A N/A SCC15 Homo sapiens
C188-9 Flow cytometry Influence on cell apoptosis N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC25 Homo sapiens
C188-9 Wound healing assay Influence on cell mobility N/A N/A SCC15 Homo sapiens
C188-9 Wound healing assay Influence on cell mobility N/A N/A SCC25 Homo sapiens
C188-9 MTT Influence on cisplatin cell sensitivity N/A N/A SCC15 Homo sapiens
C188-9 MTT Influence on cisplatin cell sensitivity N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Immunofluorescence Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Immunofluorescence Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Flow cytometry Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Flow cytometry Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 ELISA Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 ELISA Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Virus yield examination Influence on protein in presence of IL6 and vrus 0.90 µM A375 Homo sapiens
C188-9 Virus yield examination Influence on protein in presence of IL6 and vrus 0.90 µM C8161 Homo sapiens
C188-9 Luminex Influence on STAT3 levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6 p-STAT3
C188-9 Luminex Influence on STAT3 levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6 STAT3
C188-9 Alcian Blue-PAS staining Influence on lung epithelium thickness in presence of house dust mite 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in serum in presence of house dust mites 10.00 mg/kg serum Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg bronchoalveolar lavage fluid Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg bronchoalveolar lavage fluid Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg bronchoalveolar lavage fluid Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg bronchoalveolar lavage fluid Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD3- T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD3- T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD3- T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD3- T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A HBEC Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1563 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1437 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H661 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H2126 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A A549 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1573 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1299 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1975 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3α Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3β Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC3-KT Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1563 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1437 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H661 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H2126 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A A549 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1573 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1299 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1975 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3α Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3β Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC3-KT Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1563 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1437 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H661 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H2126 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A A549 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1573 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1299 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1975 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3α Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3β Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC3-KT Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1563 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1437 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H661 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H2126 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A A549 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1573 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1299 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1975 Homo sapiens
C188-9 Luminex beads Influence o protein levels 30.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.03 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.01 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.30 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.10 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 1.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 3.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 10.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 100.00 µM A549 Homo sapiens p-STAT3
C188-9 MTT Influence on cell proliferation 0.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 0.03 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 0.01 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 0.30 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 0.10 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 1.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 3.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 10.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 30.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 100.00 µM A549 Homo sapiens
C188-9 RT-PCR Influence on STAT3 target gene expression 30.00 µM A549 Homo sapiens
C188-9 RT-PCR Influence on STAT3 target gene expression 30.00 µM A549 Homo sapiens
C188-9 RT-PCR Influence on STAT3 target gene expression 30.00 µM A549 Homo sapiens
C188-9 RT-PCR Influence on STAT3 target gene expression 30.00 µM A549 Homo sapiens
C188-9 Flow cytometry Influence on apoptosis 30.00 µM A549 Homo sapiens
C188-9 Tumor volume, weight Influence on tumor growth 50.00 mg/kg A549(xenograft) Mus musculus
C188-9 RT-PCR Influence on STAT3 target gene expression in tumor 50.00 mg/kg A549(xenograft) Mus musculus
C188-9 RT-PCR Influence on STAT3 target gene expression in tumor 50.00 mg/kg A549(xenograft) Mus musculus
C188-9 RT-PCR Influence on STAT3 target gene expression in tumor 50.00 mg/kg A549(xenograft) Mus musculus
C188-9 RT-PCR Influence on STAT3 target gene expression in tumor 50.00 mg/kg A549(xenograft) Mus musculus