BBMD3 (berbamine derivative)

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition JAK2, SRC, STAT; Natural product
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Molecular oncology Sangkil Nam, Jun Xie, Angela Perkins, Yuelong Ma, Fan Yang, Jun Wu, Yan Wang, Rong-Zhen Xu, Wendong Huang, David A Horne, Richard Jove, 6, 5, None, 2012-06-02, 10.1016/j.molonc.2012.05.002 10.1016/j.molonc.2012.05.002 22717603 PMC3439602

Filter data

Compound BBMD3 (berbamine derivative)
Experiment types Autophosphorylation kinase activity, ELISA, MTS Assay , Western Blot
Concentrations 0.10, 0.50, 1.00, 10.00, 2.00, 20.00, 3.00, 4.00, 5.00, N/A
Cell lines A2058, A375, DU145, G361, NHDF, SK-MEL-28, SK-MEL-5
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3, p-STAT3(Tyr705)
Other Bcl-X, Erk-1/2, JAK2, Mcl-1, Src, Tyk2, p-Erk1/2(Thr202/Tyr204), p-JAK2, p-JAK2(Tyr1007/1008), p-Src(Tyr419), p-Tyk2(Tyr1054/1055)

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
BBMD3 (berbamine derivative) MTS Assay Cell viability- determination of IC50 value N/A N/A A2058 Homo sapiens
BBMD3 (berbamine derivative) MTS Assay Cell viability- determination of IC50 value N/A N/A DU145 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 2.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 3.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 4.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 1.00 µM A375 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 2.00 µM A375 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 3.00 µM A375 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 4.00 µM A375 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 5.00 µM A375 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 10.00 µM A375 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 1.00 µM G361 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 2.00 µM G361 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 3.00 µM G361 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 4.00 µM G361 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 5.00 µM G361 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 10.00 µM G361 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 1.00 µM SK-MEL-28 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 2.00 µM SK-MEL-28 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 3.00 µM SK-MEL-28 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 4.00 µM SK-MEL-28 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 5.00 µM SK-MEL-28 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 10.00 µM SK-MEL-28 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 1.00 µM SK-MEL-5 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 2.00 µM SK-MEL-5 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 3.00 µM SK-MEL-5 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 4.00 µM SK-MEL-5 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 5.00 µM SK-MEL-5 Homo sapiens
BBMD3 (berbamine derivative) ELISA Cell viability 10.00 µM SK-MEL-5 Homo sapiens
BBMD3 (berbamine derivative) MTS Assay Cell viability 0.10 µM NHDF Homo sapiens
BBMD3 (berbamine derivative) MTS Assay Cell viability 0.50 µM NHDF Homo sapiens
BBMD3 (berbamine derivative) MTS Assay Cell viability 1.00 µM NHDF Homo sapiens
BBMD3 (berbamine derivative) MTS Assay Cell viability 5.00 µM NHDF Homo sapiens
BBMD3 (berbamine derivative) MTS Assay Cell viability 10.00 µM NHDF Homo sapiens
BBMD3 (berbamine derivative) MTS Assay Cell viability 20.00 µM NHDF Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens p-STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A375 Homo sapiens p-STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM G361 Homo sapiens p-STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM SK-MEL-5 Homo sapiens p-STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A375 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM G361 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM SK-MEL-5 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A375 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM G361 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM SK-MEL-5 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A375 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM G361 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM SK-MEL-5 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens p-STAT3(Tyr705)
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens p-STAT3(Tyr705)
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens p-STAT3(Tyr705)
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens p-STAT3(Tyr705)
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 0.50 µM A2058 Homo sapiens p-STAT3(Tyr705)
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 1.00 µM A2058 Homo sapiens p-STAT3(Tyr705)
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 3.00 µM A2058 Homo sapiens p-STAT3(Tyr705)
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 5.00 µM A2058 Homo sapiens p-STAT3(Tyr705)
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 10.00 µM A2058 Homo sapiens p-STAT3(Tyr705)
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 0.50 µM A2058 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 1.00 µM A2058 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 3.00 µM A2058 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 5.00 µM A2058 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 10.00 µM A2058 Homo sapiens STAT3
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 3.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 3.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Inhibition of Jak/STAT signalling in presence of IL-6 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) MTS Assay Influence on cell apoptosis in presence of IL-6 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 0.10 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 0.10 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Autophosphorylation kinase activity Influence on JAK2 phosphorylation 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Influence on apoptosis 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Influence on apoptosis 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Influence on apoptosis 10.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Influence on apoptosis 0.50 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Influence on apoptosis 5.00 µM A2058 Homo sapiens
BBMD3 (berbamine derivative) Western Blot Influence on apoptosis 10.00 µM A2058 Homo sapiens