Avicin D

Name Value
Weight 2083.279 g/mol
Zinc ID N/A
Smiles C[C@H]1O[C@H]([C@@H]([C@H]([C@H]1O)O)O[C@@H]2OC[C@H]([C@@H]([C@H]2O)O)O)OC[C@H]3O[C@H]([C@@H]([C@H]([C@@H]3O)O)NC(=O)C)O[C@@H]4[C@@]([C@H]5[C@@]([C@@H]6[C@]([C@]7(C(=CC6)[C@H]8[C@@]([C@@H](C7)O)(C[C@@H]([C@@](C8)(C)C)OC(=O)/C(=C/CC[C@](O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)OC(=O)/C(=C/CCC(O)(C=C)C)/CO)C)(C=C)C)/CO)C(=O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O[C@@H]1O[C@H]([C@@H]([C@H]([C@H]1O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)O[C@@H]1O[C@H]([C@@H]([C@H]1O)O)CO)C)O)O)CO)C)(CC5)C)(CC4)C)(C)C
Molecular formula C98H155NO46
Mode of inhibition JAK1, JAK2, JAK3, STAT; Natural product
CAS 197787-20-5

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities. PloS one Valsala Haridas, Goshi Nishimura, Zhi-Xiang Xu, Fiona Connolly, Margaret Hanausek, Zbigniew Walaszek, Robert Zoltaszek, Jordan U Gutterman, 4, 5, None, 2009-05-18, 10.1371/journal.pone.0005578 10.1371/journal.pone.0005578 19440292 PMC2680980

Filter data

Compound Avicin D
Experiment types ELISA, Flow cytometry Annexin V-FITC, Immunofluorescence, Luciferase activity assay , MTT Assay , PSP assay system , Western Blot
Concentrations 0.04, 0.06, 0.07, 0.12, 0.15, 0.25, 0.30, 0.50, 0.60, 1.00, 1.25, 10.00, 2.00, 2.50, 5.00
Cell lines A431, HepG2, MM1, OVCAR3, RPMI-8226, SKO-007, U266
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3(S727), p-STAT3(Y705)
Other Actin, Actin , Bcl-2, Cleaved PARP, Cyclin D1, IL-6, JAK, Mcl-1, Survivn , VEGF, c-myc, p-JAK1, p-JAK2

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity 0.12 µM U266 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 0.25 µM U266 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 0.50 µM U266 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 0.12 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity 0.25 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity 0.50 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity in presence of IL-6 0.12 µM U266 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity in presence of IL-6 0.25 µM U266 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity in presence of IL-6 0.50 µM U266 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity in presence of IL-6 1.00 µM U266 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity in presence of IL-6 0.12 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity in presence of IL-6 0.25 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity in presence of IL-6 0.50 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity in presence of IL-6 1.00 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity 1.00 µM RPMI-8226 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity 1.00 µM RPMI-8226 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 1.00 µM RPMI-8226 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity 1.00 µM SKO-007 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity 1.00 µM SKO-007 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 1.00 µM SKO-007 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity 1.00 µM MM1 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity 1.00 µM MM1 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 1.00 µM MM1 Homo sapiens STAT3
Avicin D Immunofluorescence Influence on protein translocation in presence of IL-6 1.00 µM U266 Homo sapiens STAT3
Avicin D Immunofluorescence Influence on protein translocation in presence of IL-6 1.00 µM RPMI-8226 Homo sapiens STAT3
Avicin D Luciferase activity assay Influence on protein activity in presence of IL-6 0.25 µM U266 Homo sapiens STAT3
Avicin D Luciferase activity assay Influence on protein activity in presence of IL-6 0.50 µM U266 Homo sapiens STAT3
Avicin D Luciferase activity assay Influence on protein activity in presence of IL-6 1.00 µM U266 Homo sapiens STAT3
Avicin D ELISA Influence on IL-6 production 0.06 µM U266 Homo sapiens
Avicin D ELISA Influence on IL-6 production 0.12 µM U266 Homo sapiens
Avicin D ELISA Influence on IL-6 production 0.25 µM U266 Homo sapiens
Avicin D ELISA Influence on IL-6 production 0.50 µM U266 Homo sapiens
Avicin D ELISA Influence on IL-6 production 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity in presence AG490 1.00 µM U266 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity in presence AG490 1.00 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity in presence of HCBH 1.00 µM U266 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity in presence of HCBH 1.00 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein dephosphorylation on presence of okadaic acid 1.00 µM U266 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein dephosphorylation on presence of okadaic acid 1.00 µM U266 Homo sapiens STAT3
Avicin D Western Blot Influence on protein dephosphorylation on presence of fostriecin 1.00 µM U266 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein dephosphorylation on presence of fostriecin 1.00 µM U266 Homo sapiens STAT3
Avicin D PSP assay system Influence on protein activity 1.00 µM U266 Homo sapiens
Avicin D PSP assay system Influence on protein activity 2.00 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability 0.04 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability 0.07 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability 0.15 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability 0.30 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability 0.60 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability 1.25 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability 2.50 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability 5.00 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability 10.00 µM U266 Homo sapiens
Avicin D Flow cytometry Annexin V-FITC Influence on cell apoptosis 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on cell apoptosis 1.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on cell apoptosis 1.00 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability in presence of OA 0.04 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability in presence of OA 0.07 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability in presence of OA 0.15 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability in presence of OA 0.30 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability in presence of OA 0.60 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability in presence of OA 1.25 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability in presence of OA 2.50 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability in presence of OA 5.00 µM U266 Homo sapiens
Avicin D MTT Assay Influence on cell viability in presence of OA 10.00 µM U266 Homo sapiens
Avicin D Western Blot Influence on protein activity 1.00 µM A431 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity 1.00 µM A431 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 1.00 µM A431 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity 1.00 µM OVCAR3 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity 1.00 µM OVCAR3 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 1.00 µM OVCAR3 Homo sapiens STAT3
Avicin D Western Blot Influence on protein activity 1.00 µM HepG2 Homo sapiens p-STAT3(Y705)
Avicin D Western Blot Influence on protein activity 1.00 µM HepG2 Homo sapiens p-STAT3(S727)
Avicin D Western Blot Influence on protein activity 1.00 µM HepG2 Homo sapiens STAT3