YM-341619

Name	Value
Weight	0.000 N/A
Zinc ID	N/A
Smiles	N/A
Molecular formula	N/A
Mode of inhibition	STAT and IL-4; Non-peptide small molecule
CAS	643082-52-4

Clinical Trials

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References

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Publication	DOI	Pubmed	PMCID
Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorganic & medicinal chemistry Shinya Nagashima, Hiroshi Nagata, Masahiro Iwata, Masaki Yokota, Hiroyuki Moritomo, Masaya Orita, Sadao Kuromitsu, Akiko Koakutsu, Keiko Ohga, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi Tsukamoto, 16, 13, 2008-07-01, 2008-05-17, 10.1016/j.bmc.2008.05.031	10.1016/j.bmc.2008.05.031	18534856	18534856

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Compound	YM-341619
Experiment types	ELISA
Concentrations	0.01, 0.10, 1.00, 10.00
Cell lines	Spleen T cells
Organisms	Mus musculus
Animal models	c57BL/6
STAT proteins
Other	IFNγ, IL-4

Experiments

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Compound	Experiment type	Investigated event	Concentration	Cell line	Organism	Animal model	Stat protein	Details
YM-341619	ELISA	Influence on cytokine production	0.01 µM	Spleen T cells	Mus musculus	c57BL/6
YM-341619	ELISA	Influence on cytokine production	0.10 µM	Spleen T cells	Mus musculus	c57BL/6
YM-341619	ELISA	Influence on cytokine production	1.00 µM	Spleen T cells	Mus musculus	c57BL/6
YM-341619	ELISA	Influence on cytokine production	10.00 µM	Spleen T cells	Mus musculus	c57BL/6
YM-341619	ELISA	Influence on cytokine production	0.01 µM	Spleen T cells	Mus musculus	c57BL/6
YM-341619	ELISA	Influence on cytokine production	0.10 µM	Spleen T cells	Mus musculus	c57BL/6
YM-341619	ELISA	Influence on cytokine production	1.00 µM	Spleen T cells	Mus musculus	c57BL/6
YM-341619	ELISA	Influence on cytokine production	10.00 µM	Spleen T cells	Mus musculus	c57BL/6

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