Xanthohumol

Name Value
Weight 354.402 g/mol
Zinc ID ZINC5158937
Smiles COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)/C=C/c1ccc(O)cc1
Molecular formula C21H22O5
Mode of inhibition EGFR, Nf-κB, STAT; Natural product
CAS 6754-58-1

Clinical Trials

Study title Status Conditions Link
Xanthohumol Metabolism and Signature Recruiting Healthy NCT03735420
Xanthohumol and Metabolic Syndrome Completed Metabolic Syndrome NCT01367431
Xanthohumol and Prevention of DNA Damage Completed Oxidative Stress NCT02432651
Effects of Xanthohumol on Metabolic Syndrome Progression Recruiting Metabolic Syndrome NCT03561116
Hop Botanical Dietary Supplements - Metabolism and Safety in Women Active, not recruiting Food-Drug Interactions NCT02848430
Improved Oral Bioavailability of Curcumin Incorporated Into Micelles Completed Pharmacokinetics of New Curcumin Formulations|Safety of New Curcumin Formulations NCT01982734

References

Publication DOI Pubmed PMCID
Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells. Oncology reports Hasaya Dokduang, Puangrat Yongvanit, Nisana Namwat, Chawalit Pairojkul, Sakkarn Sangkhamanon, Mika Sakurai Yageta, Yoshinori Murakami, Watcharin Loilome, 35, 4, None, 2016-01-21, 10.3892/or.2016.4584 10.3892/or.2016.4584 26794001 26794001

Vendors

Company Lnk to product
Tocris https://www.tocris.com/products/xanthohumol_4686
MedChemExpress https://www.medchemexpress.com/Xanthohumol.html
Caymanchemical https://www.caymanchem.com/product/15399/xanthohumol
Adooq https://www.adooq.com/xanthohumol.html
Santa Cruz Biotechnology https://www.scbt.com/p/xanthohumol-from-hop-humulus-lupulus-6754-58-1
Biovision https://www.biovision.com/xanthohumol.html
Enzo Lifesciences https://www.enzolifesciences.com/ALX-350-280/xanthohumol/

Filter data

Compound Xanthohumol
Experiment types Body weight, Immunohistochemistry, SRB assay , TUNEL, Tumor volume, Water intake ratio , Western Blot
Concentrations 10.00, 2.50, 20.00, 5.00, 50.00
Cell lines KKU-M139, KKU-M214, KKU-M214 (xenograft)
Organisms Homo sapiens, Mus musculus
Animal models BALB/c
STAT proteins STAT3, p-STAT3
Other AKT, BAX, Bcl-2, CDK4, Cyclin D1, Histone H1, Ki-67, NF-κB, p-AKT, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Xanthohumol SRB assay Influence on cell proliferation 2.50 µM KKU-M214 Homo sapiens
Xanthohumol SRB assay Influence on cell proliferation 5.00 µM KKU-M214 Homo sapiens
Xanthohumol SRB assay Influence on cell proliferation 10.00 µM KKU-M214 Homo sapiens
Xanthohumol SRB assay Influence on cell proliferation 20.00 µM KKU-M214 Homo sapiens
Xanthohumol SRB assay Influence on cell proliferation 50.00 µM KKU-M214 Homo sapiens
Xanthohumol SRB assay Influence on cell proliferation 2.50 µM KKU-M139 Homo sapiens
Xanthohumol SRB assay Influence on cell proliferation 5.00 µM KKU-M139 Homo sapiens
Xanthohumol SRB assay Influence on cell proliferation 10.00 µM KKU-M139 Homo sapiens
Xanthohumol SRB assay Influence on cell proliferation 20.00 µM KKU-M139 Homo sapiens
Xanthohumol SRB assay Influence on cell proliferation 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens p-STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens p-STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens p-STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens p-STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens p-STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens p-STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens STAT3
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on apoptotic protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Tumor volume Influence on tumor growth 20.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Tumor volume Influence on tumor growth 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Body weight Influence on tumor growth 20.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Body weight Influence on tumor growth 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Water intake ratio Influence on tumor growth 20.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Water intake ratio Influence on tumor growth 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Western Blot Influence on protein activity in tumor tissue 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c p-STAT3
Xanthohumol Western Blot Influence on protein activity in tumor tissue 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c STAT3
Xanthohumol Western Blot Influence on protein activity in tumor tissue 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Immunohistochemistry Influence on cell apoptosis in tumor tissue 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol TUNEL Influence on cell apoptosis in tumor tissue 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 10.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 20.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M139 Homo sapiens
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c
Xanthohumol Western Blot Influence on protein activity in presence of IL-6 50.00 µM KKU-M214 (xenograft) Mus musculus BALB/c