TPCA-1

Name Value
Weight 279.290 g/mol
Zinc ID ZINC3960707
Smiles C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F
Molecular formula C12H10FN3O2S
Mode of inhibition N/A
CAS 507475-17-4

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancers. Molecular cancer therapeutics Jing Nan, Yuping Du, Xing Chen, Qifeng Bai, Yuxin Wang, Xinxin Zhang, Ning Zhu, Jing Zhang, Jianwen Hou, Qin Wang, Jinbo Yang, 13, 3, None, 2014-01-08, 10.1158/1535-7163.MCT-13-0464 10.1158/1535-7163.MCT-13-0464 24401319 24401319

Vendors

Company Lnk to product
MERCK/Sigma Aldrich https://www.sigmaaldrich.com/PL/pl/product/sigma/t1452?gclid=CjwKCAiA8bqOBhANEiwA-sIlNwHzquL_deWmD-BSfXL39XlNE9LVeeTT5wtTuvbBGbAAZcknbU0uvBoC5P0QAvD_BwE
Selleckchem https://www.selleck.eu/products/tpca-1.html?gclid=CjwKCAiA8bqOBhANEiwA-sIlN2liX5oGfwxSN_u-vjQl1ZMj1QC9uKXNNDa8WS9S7CrkeCEkjszlWxoC-TEQAvD_BwE
Tocris https://www.tocris.com/products/tpca-1_2559?gclid=CjwKCAiA8bqOBhANEiwA-sIlN-jp94_-0swUInBw5pHCiGd7o2wrwcmPge0iupdYFE4yN0ECu9EfcxoC-swQAvD_BwE
Molport https://www.molport.com/shop/moleculelink/2-carbamoylamino-5-4-fluorophenyl-thiophene-3-carboxamide/8616105?searchtype=text-search
ChemScene https://www.chemscene.com/507475-17-4.html
Caymanchemicals https://www.caymanchem.com/product/15115/tpca-1
APExBIO https://www.apexbt.com/tpca-1.html
MedChemExpress https://www.medchemexpress.com/TPCA-1.html

Filter data

Compound TPCA-1
Experiment types MTT, Western Blot
Concentrations 0.10, 0.25, 0.50, 0.75, 1.00, 1.50, 10.00, 2.00, 4.00, 6.00, 8.00
Cell lines 293T, A549, HCC827, NCI-H1975
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3
Other AKT, GAPDH, IkBa, p-AKT, p-p65

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.00 µM 293T Homo sapiens p-STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.00 µM 293T Homo sapiens STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNa 1.00 µM 293T Homo sapiens p-STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IFNa 1.00 µM 293T Homo sapiens STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IFNa 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNa 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNa 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNa 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNa 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNg 1.00 µM 293T Homo sapiens p-STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IFNg 1.00 µM 293T Homo sapiens STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IFNg 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNg 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNg 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNg 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IFNg 1.00 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.10 µM 293T Homo sapiens p-STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.25 µM 293T Homo sapiens p-STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.50 µM 293T Homo sapiens p-STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.75 µM 293T Homo sapiens p-STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.50 µM 293T Homo sapiens p-STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 2.00 µM 293T Homo sapiens p-STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.10 µM 293T Homo sapiens STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.25 µM 293T Homo sapiens STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.50 µM 293T Homo sapiens STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.75 µM 293T Homo sapiens STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.50 µM 293T Homo sapiens STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 2.00 µM 293T Homo sapiens STAT3
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.10 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.25 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.50 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 0.75 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 1.50 µM 293T Homo sapiens
TPCA-1 Western Blot Influence on protein activity in presence of IL-6 2.00 µM 293T Homo sapiens
TPCA-1 MTT Influence on cell proliferation 2.00 µM A549 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 4.00 µM A549 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 6.00 µM A549 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 8.00 µM A549 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 10.00 µM A549 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 2.00 µM NCI-H1975 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 4.00 µM NCI-H1975 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 6.00 µM NCI-H1975 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 8.00 µM NCI-H1975 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 10.00 µM NCI-H1975 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 2.00 µM HCC827 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 4.00 µM HCC827 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 6.00 µM HCC827 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 8.00 µM HCC827 Homo sapiens
TPCA-1 MTT Influence on cell proliferation 10.00 µM HCC827 Homo sapiens