TG101209

Name Value
Weight 509.680 g/mol
Zinc ID ZINC63539888
Smiles Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1
Molecular formula C26H35N7O2S
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS 936091-14-4

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
[Studies on cytosol thyroid hormone binding proteins in the rat liver: Part III. Partial purification and binding characteristics of thyroxine-binding protein in hypothyroid rat liver cytosol and serum]. Nihon Naibunpi Gakkai zasshi M Nanno, H Nakamura, S Hamada, T Yoshimi, H Imura, R Ohtsuka, 63, 1, 1987-01-20, None, 10.1097/JTO.0b013e31820d9d11 10.1097/JTO.0b013e31820d9d11 3104103 PMC3104103

Vendors

Company Lnk to product
MedChemExpress https://www.medchemexpress.com/TG101209.html
Adooq https://www.adooq.com/tg101209.html
Selleckchem https://www.selleckchem.com/products/tg101209.html
Caymanchemicals https://www.caymanchem.com/product/14696/tg101209
APExBIO https://www.apexbt.com/tg101209.html

Filter data

Compound TG101209
Experiment types Clonogenic assay , Immunostaining , Tumor volume, Western Blot
Concentrations 1.00, 100.00, 3.00
Cell lines H460 , HCC2429 , HCC2429 (xenograft), HCC2429 K-Ras G12V
Organisms Homo sapiens, Mus musculus
Animal models athymic nude mice
STAT proteins STAT3, p-STAT3
Other AKT, Actin, Caspase-3, Cleaved Caspase-3, ERK, HA, Ki-67, Pro-Caspase-3, Survivin, p-AKT, p-ERK, vWF

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
TG101209 Western Blot Influence on protein activity 1.00 µM HCC2429 Homo sapiens p-STAT3
TG101209 Western Blot Influence on protein activity 3.00 µM HCC2429 Homo sapiens p-STAT3
TG101209 Western Blot Influence on protein activity 1.00 µM H460 Homo sapiens p-STAT3
TG101209 Western Blot Influence on protein activity 3.00 µM H460 Homo sapiens p-STAT3
TG101209 Western Blot Influence on protein activity 1.00 µM HCC2429 Homo sapiens STAT3
TG101209 Western Blot Influence on protein activity 3.00 µM HCC2429 Homo sapiens STAT3
TG101209 Western Blot Influence on protein activity 1.00 µM H460 Homo sapiens STAT3
TG101209 Western Blot Influence on protein activity 3.00 µM H460 Homo sapiens STAT3
TG101209 Western Blot Influence on protein activity 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity 3.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity 3.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity 3.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity 3.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity 3.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity 3.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity 3.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity 3.00 µM H460 Homo sapiens
TG101209 Clonogenic assay Influence on radiosensitization 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM HCC2429 Homo sapiens p-STAT3
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM H460 Homo sapiens p-STAT3
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM HCC2429 Homo sapiens STAT3
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM H460 Homo sapiens STAT3
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM HCC2429 Homo sapiens
TG101209 Western Blot Influence on protein activity after radiation 1.00 µM H460 Homo sapiens
TG101209 Western Blot Influence on protein activity in transfected cells 1.00 µM HCC2429 K-Ras G12V Homo sapiens
TG101209 Western Blot Influence on protein activity in transfected cells 3.00 µM HCC2429 K-Ras G12V Homo sapiens
TG101209 Western Blot Influence on protein activity in transfected cells 1.00 µM HCC2429 K-Ras G12V Homo sapiens
TG101209 Western Blot Influence on protein activity in transfected cells 3.00 µM HCC2429 K-Ras G12V Homo sapiens
TG101209 Western Blot Influence on protein activity in transfected cells 1.00 µM HCC2429 K-Ras G12V Homo sapiens
TG101209 Western Blot Influence on protein activity in transfected cells 3.00 µM HCC2429 K-Ras G12V Homo sapiens
TG101209 Western Blot Influence on protein activity in transfected cells 1.00 µM HCC2429 K-Ras G12V Homo sapiens
TG101209 Western Blot Influence on protein activity in transfected cells 3.00 µM HCC2429 K-Ras G12V Homo sapiens
TG101209 Tumor volume Influence on tumor growth 100.00 mg/kg HCC2429 (xenograft) Mus musculus athymic nude mice
TG101209 Tumor volume Influence on tumor growth with radiation 100.00 mg/kg HCC2429 (xenograft) Mus musculus athymic nude mice
TG101209 Immunostaining Influence on cell proliferation in tumor tissue 100.00 mg/kg HCC2429 (xenograft) Mus musculus athymic nude mice
TG101209 Immunostaining Influence on cell proliferation in tumor tissue 100.00 mg/kg HCC2429 (xenograft) Mus musculus athymic nude mice
TG101209 Immunostaining Influence on cell proliferation in tumor tissue 100.00 mg/kg HCC2429 (xenograft) Mus musculus athymic nude mice