Sulforaphane

Name Value
Weight 177.300 g/mol
Zinc ID ZINC3875035
Smiles CS(=O)CCCCN=C=S
Molecular formula C6H11NOS2
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS 4478-93-7

Clinical Trials

Study title Status Conditions Link
Protective Effects of the Nutritional Supplement Sulforaphane on Doxorubicin-Associated Cardiac Dysfunction Recruiting Anthracycline Related Cardiotoxicity in Breast Cancer NCT03934905
A 6-month Study to Evaluate Sulforaphane add-on Effects in Treatment of Schizophrenia Completed Schizophrenia NCT02880462
Effects of Sulforaphane in Patients With Prodromal to Mild Alzheimer's Disease Not yet recruiting Alzheimer Disease NCT04213391
Effects of Sulforaphane on Cognitive Function in Patients With Frontal Brain Damage Not yet recruiting Frontal Lobe Dysfunction NCT04252261
Effect of Topical Sulforaphane on Skin Aging and With Ultraviolet and Visible Light Exposure Recruiting Skin Aging NCT03730649
Effect of Topical Sulforaphane on Skin Fragility Seen in Skin Aging and With Ultraviolet Exposure Terminated Aging NCT03126539
Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder Completed Autism Spectrum Disorder|Autistic Disorder|Neurodevelopmental Disorder|Childhood Developmental Disorders, Pervasive NCT02909959
Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers Recruiting Lung Cancer NCT03232138
Sulforaphane to Reduce Symptoms of Schizophrenia Completed Schizophrenia|Schizoaffective Disorder NCT02810964
A 12-weeks Study to Evaluate Sulforaphane in the Treatment of Depression Not yet recruiting Depressive Disorder NCT04246905
Sulforaphane in Treating Patients With Recurrent Prostate Cancer Completed Adenocarcinoma of the Prostate|Recurrent Prostate Cancer NCT01228084
Sulforaphane in a New Jersey (NJ) Population of Individuals With Autism Recruiting Autism|Autistic Disorder|Autism Spectrum Disorder|Autistic Behavior NCT02677051
A 12-weeks Study to Evaluate Sulforaphane in Treatment of Autism Spectrum Disorder Completed Autism Spectrum Disorder NCT02879110
Open Label of Clinical Trial of Sulforaphane in Children With Autism Completed Autism NCT02654743
Sulforaphane Treatment of Children With Autism Spectrum Disorder (ASD) Completed Autism Spectrum Disorder NCT02561481
Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD Completed COPD NCT01335971
Sulforaphane Supplementation in Atopic Asthmatics Completed Asthma NCT01845493
Randomized, Phase II Clinical Trial of Sulforaphane in Bladder Cancer Chemoprevention Not yet recruiting Bladder Cancer|Bladder Tumor|Urothelial Carcinoma NCT03517995
Sulforaphane-rich Broccoli Sprout Extract for Autism Completed Autism NCT01474993
Effects of Sulforaphane on Normal Prostate Tissue Completed Prostate Cancer NCT00946309
An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients With Schizophrenia Completed Schizophrenia NCT01716858
Broccoli In Osteoarthritis Recruiting Osteoarthritis NCT03878368
Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions Completed Adverse Drug Interactions NCT00621309
Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation Completed Cystic Fibrosis NCT01315665
Pilot Study Evaluating Sulforaphane in Atypical Nevi-Precursor Lesions Completed Atypical Nevi|Melanoma NCT01568996
Decreasing Risk of Psychosis by Sulforaphane (DROPS Trial) Recruiting Clinical High Risk Syndrome of Psychosis NCT03932136
Study to Evaluate the Effect of Sulforaphane in Broccoli Sprout Extract on Breast Tissue Completed Breast Cancer NCT00982319
Accumulation of Dietary Bioactives and Prostate Cancer Active, not recruiting Prostate Cancer NCT04046653
Topical Application of Sulforaphane-containing Broccoli Sprout Extracts on Radiation Dermatitis Completed Breast Cancer|Dermatitis NCT00894712
Utilizing MRI to Study the Effect of Sulforaphane on Prostate Cancer Terminated Prostate Cancer NCT02404428
The Bioavailability Of Sulforaphane From Broccoli Soups Study (BOBS) Completed Healthy NCT02300324
Biomarkers of Sulforaphane/Broccoli Sprout Extract in Prostate Cancer Recruiting Prostate Cancer NCT03665922
Effect of Sulforaphane on Prostate CAncer PrEvention Completed Prostate Cancer NCT01950143
Cross-Over Broccoli Sprouts Trial Completed Healthy NCT01008826
Effect of Broccoli Sprout on Blood Levels of Sulforaphane to Reduce Responsiveness of Immune System Completed Healthy Volunteers NCT01357070
Effects of Sulforaphane (SFN) on Immune Response to Live Attenuated Influenza Virus in Smokers and Nonsmokers Completed Smoking NCT01269723
Effect of Broccoli Sprouts Homogenate on SS RBC Completed Sickle Red Blood Cell|Fetal Hemoglobin|Oxidative Stress NCT01715480
Clinical Trial With Broccoli Sprout Extract to Patients With Type 2 Diabetes Active, not recruiting Diabetes Mellitus, Non-Insulin-Dependent NCT02801448
Chemoprevention of Prostate Cancer, HDAC Inhibition and DNA Methylation Completed Prostate Cancer Prevention NCT01265953
Pilot Study Evaluating Broccoli Sprouts in Advanced Pancreatic Cancer [POUDER Trial] Unknown status Pancreatic Ductal Adenocarcinoma NCT01879878
Effect of Sulforaphane-rich Broccoli Sprout Homogenate on Ozone Induced Inflammation Through Modulation of NRF2 Completed Healthy NCT01625130
Broccoli Sprout Intervention in Qidong, P.R. China Completed Environmental Carcinogenesis NCT01437501
Effects of 2 Different Broccoli Sprout Containing Supplements on Nasal Cells in Healthy Volunteers Completed Healthy Adult Volunteers NCT01129466
Broccoli Sprout Extract in Treating Women Who Have Had a Mammogram and Breast Biopsy Completed Breast Cancer|Precancerous Condition NCT00843167
Broccoli Supplement Dose Response Completed Healthy Volunteers NCT03399656
The Effect of Broccoli Sprout Extract and Probiotics for Eradication of Helicobacter Pylori Active, not recruiting Helicobacter Pylori Infection NCT03220542
Sulforadex in Healthy Human Males MAD Completed Prostate Cancer NCT02055716
Effect of Orally Delivered Phytochemicals on Aging and Inflammation in the Skin Recruiting Healthy Adults NCT03289832
BSE on Blood Glucose Recruiting Blood Glucose, High NCT03763240
Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants Completed Environmental Carcinogenesis NCT02656420
Broccoli Sprout Extracts in Healthy Volunteers: A Pilot Study of Nrf2 Pathway Modulation in Oral Mucosa Completed Healthy Subject NCT02023931
Dietary Histone Deacetylase Inhibitors (HDAC) Terminated Histone Deacetylase (HDAC) Activity NCT01543074
Vitamin D and Arterial Stiffness in Elderly Enrolling by invitation Vitamin D Deficiency|Arterial Stiffness NCT03649802
Broccoli Sprout Extract Effects on Allergic Inflammation in the Nose Completed Allergic Airway Disease NCT00882115
Sulforadex in Healthy Volunteers SAD Completed Stage, Prostate Cancer NCT01948362
Bioavailability and Mucosal Bioactivity of Avmacol® in Healthy Volunteers Completed Healthy NCT02800265
Effects of Broccoli Sprout Extract on Allergy Rhinitis Completed Rhinitis,Allergic NCT02885025
Bioavailability of Chemopreventive and Nutritional Compounds in Broccoli Completed Bioavailability NCT01743924
Broccoli Ileo Study Completed Ileostomy - Stoma NCT04113928
SFX-01 After Subarachnoid Haemorrhage Completed Subarachnoid Hemorrhage, Spontaneous NCT02614742
Prevention of Alcohol Intolerance Completed Alcohol Sensitivity NCT01845220
Dietary Interventions in Asthma Treatment: Sprouts Study Terminated Asthma|Allergy NCT01183923
Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients Unknown status Colon Cancer NCT01344330
Diet and Vascular Health Study Completed Cardiovascular Disease NCT01114399
The Conversion of ENcapsulated GlucorAphanin, Gut Microbiota Phylogeny and gEnotype Study (ENGAGE) Completed Healthy NCT01927666
SFX-01 in the Treatment and Evaluation of Metastatic Breast Cancer Completed Breast Neoplasm NCT02970682
Broccoli Sprout Extract in Preventing Recurrence in Patients With Tobacco-Related Head and Neck Squamous Cell Cancer Active, not recruiting HNSCC|Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma|Tobacco-Related Carcinoma|Carcinoma in Situ|Dysplasia|Hyperplasia|Premalignant Lesion NCT03182959
Effects of the Consumption of Broccoli Sprouts in Overweight Subjects Completed Obesity|Inflammation NCT03390855
Broccoli Sprout/Broccoli Seed Extract Supplement in Decreasing Toxicity in Heavy Smokers Active, not recruiting Current Every Day Smoker|Tobacco Smoking NCT03402230

References

Publication DOI Pubmed PMCID
The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PloS one Sophia Pinz, Samy Unser, Anne Rascle, 9, 6, None, 2014-06-09, 10.1371/journal.pone.0099391 10.1371/journal.pone.0099391 24910998 PMC4051870

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/sulforaphane.html

Filter data

Compound Sulforaphane
Experiment types RT-qPCR, Trypan Blue staining , WST-1, Western Blot
Concentrations 0.10, 0.40, 0.50, 1.00, 10.00, 100.00, 2.00, 5.00
Cell lines Ba/F3, Ba/F3-1*6, K562
Organisms Homo sapiens
Animal models
STAT proteins STAT5A, STAT5B, p-STAT5
Other 36b4, Cic, Cis, Cis , JunB, Osm, Pim-1, Socs-1, c-Fos, c-Myc, α-tubulin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 0.40 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 2.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 0.40 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 2.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 0.40 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 2.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 0.40 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 2.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression in presence of IL-3 10.00 µM Ba/F3 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 0.10 µM Ba/F3 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 1.00 µM Ba/F3 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 10.00 µM Ba/F3 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 100.00 µM Ba/F3 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 0.10 µM Ba/F3-1*6 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 1.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 100.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 0.10 µM K562 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 1.00 µM K562 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 10.00 µM K562 Homo sapiens
Sulforaphane WST-1 Influence on cytotoxicity 100.00 µM K562 Homo sapiens
Sulforaphane Trypan Blue staining Influence on cell viability 0.50 µM Ba/F3 Homo sapiens
Sulforaphane Trypan Blue staining Influence on cell viability 5.00 µM Ba/F3 Homo sapiens
Sulforaphane Trypan Blue staining Influence on cell viability 0.50 µM Ba/F3-1*6 Homo sapiens
Sulforaphane Trypan Blue staining Influence on cell viability 5.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane Trypan Blue staining Influence on cell viability 0.50 µM K562 Homo sapiens
Sulforaphane Trypan Blue staining Influence on cell viability 5.00 µM K562 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM K562 Homo sapiens
Sulforaphane RT-qPCR Influence on gene expression 10.00 µM K562 Homo sapiens
Sulforaphane Western Blot Influence on protein activity 0.40 µM Ba/F3 Homo sapiens p-STAT5
Sulforaphane Western Blot Influence on protein activity 2.00 µM Ba/F3 Homo sapiens p-STAT5
Sulforaphane Western Blot Influence on protein activity 10.00 µM Ba/F3 Homo sapiens p-STAT5
Sulforaphane Western Blot Influence on protein activity 0.40 µM Ba/F3 Homo sapiens STAT5A
Sulforaphane Western Blot Influence on protein activity 2.00 µM Ba/F3 Homo sapiens STAT5A
Sulforaphane Western Blot Influence on protein activity 10.00 µM Ba/F3 Homo sapiens STAT5A
Sulforaphane Western Blot Influence on protein activity 0.40 µM Ba/F3 Homo sapiens STAT5B
Sulforaphane Western Blot Influence on protein activity 2.00 µM Ba/F3 Homo sapiens STAT5B
Sulforaphane Western Blot Influence on protein activity 10.00 µM Ba/F3 Homo sapiens STAT5B
Sulforaphane Western Blot Influence on protein activity 0.40 µM Ba/F3 Homo sapiens
Sulforaphane Western Blot Influence on protein activity 2.00 µM Ba/F3 Homo sapiens
Sulforaphane Western Blot Influence on protein activity 10.00 µM Ba/F3 Homo sapiens
Sulforaphane Western Blot Influence on protein activity 0.40 µM Ba/F3-1*6 Homo sapiens p-STAT5
Sulforaphane Western Blot Influence on protein activity 2.00 µM Ba/F3-1*6 Homo sapiens p-STAT5
Sulforaphane Western Blot Influence on protein activity 10.00 µM Ba/F3-1*6 Homo sapiens p-STAT5
Sulforaphane Western Blot Influence on protein activity 0.40 µM Ba/F3-1*6 Homo sapiens STAT5A
Sulforaphane Western Blot Influence on protein activity 2.00 µM Ba/F3-1*6 Homo sapiens STAT5A
Sulforaphane Western Blot Influence on protein activity 10.00 µM Ba/F3-1*6 Homo sapiens STAT5A
Sulforaphane Western Blot Influence on protein activity 0.40 µM Ba/F3-1*6 Homo sapiens STAT5B
Sulforaphane Western Blot Influence on protein activity 2.00 µM Ba/F3-1*6 Homo sapiens STAT5B
Sulforaphane Western Blot Influence on protein activity 10.00 µM Ba/F3-1*6 Homo sapiens STAT5B
Sulforaphane Western Blot Influence on protein activity 0.40 µM Ba/F3-1*6 Homo sapiens
Sulforaphane Western Blot Influence on protein activity 2.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane Western Blot Influence on protein activity 10.00 µM Ba/F3-1*6 Homo sapiens
Sulforaphane Western Blot Influence on protein activity 0.40 µM K562 Homo sapiens p-STAT5
Sulforaphane Western Blot Influence on protein activity 2.00 µM K562 Homo sapiens p-STAT5
Sulforaphane Western Blot Influence on protein activity 10.00 µM K562 Homo sapiens p-STAT5
Sulforaphane Western Blot Influence on protein activity 0.40 µM K562 Homo sapiens STAT5A
Sulforaphane Western Blot Influence on protein activity 2.00 µM K562 Homo sapiens STAT5A
Sulforaphane Western Blot Influence on protein activity 10.00 µM K562 Homo sapiens STAT5A
Sulforaphane Western Blot Influence on protein activity 0.40 µM K562 Homo sapiens STAT5B
Sulforaphane Western Blot Influence on protein activity 2.00 µM K562 Homo sapiens STAT5B
Sulforaphane Western Blot Influence on protein activity 10.00 µM K562 Homo sapiens STAT5B
Sulforaphane Western Blot Influence on protein activity 0.40 µM K562 Homo sapiens
Sulforaphane Western Blot Influence on protein activity 2.00 µM K562 Homo sapiens
Sulforaphane Western Blot Influence on protein activity 10.00 µM K562 Homo sapiens