STA-21

Name Value
Weight 306.317 g/mol
Zinc ID ZINC6481654
Smiles C[C@@H]1CC(=O)c2c(ccc3c2C(=O)c2cccc(O)c2C3=O)C1
Molecular formula C19H14O4
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS 111540-00-2

Clinical Trials

Study title Status Conditions Link
STA-21 Topical Efficacy on Psoriasis Completed Psoriasis NCT01047943

Visualization

References

Publication DOI Pubmed PMCID
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America Hui Song, Renxiao Wang, Shaomeng Wang, Jiayuh Lin, 102, 13, 2005-03-29, 2005-03-21, 10.1073/pnas.0409894102 10.1073/pnas.0409894102 15781862 PMC555708

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/sta-21.html
Santa Cruz Biotechnology https://www.scbt.com/p/sta-21-28882-53-3
Abcam https://www.abcam.com/sta-21-ochromycinone-stat3-inhibitor-ab145648.html
Caymanchemical https://www.caymanchem.com/product/14996/sta-21
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/sigma/sml2161?lang=pl&region=PL
Enzo https://www.enzolifesciences.com/BML-EI351/sta-21/
BioVision https://www.biovision.com/sta-21.html
MedChemExpress https://www.medchemexpress.com/ochromycinone.html

Filter data

Compound STA-21
Experiment types FACScan Flow Cytometer, Luciferse activity, Western Blot
Concentrations 20.00, 30.00
Cell lines Caov-3, HSF, MCF7, MDA-MB-231, MDA-MB-435S, MDA-MB-453, MDA-MB-453s, MDA-MB-468
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, STAT5, p-STAT3
Other Bcl-xL, Cyclin D1, GAPDH, GAPDH , p-AKT, p-EGFR, p-ERK1/2, p-JAK2, p-SRC

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
STA-21 Luciferse activity Influence on protein activity 30.00 µM Caov-3 Homo sapiens
STA-21 Western Blot Influence on protein-DNA binding 30.00 µM MDA-MB-435S Homo sapiens STAT3
STA-21 Western Blot Influence on protein-DNA binding 30.00 µM MDA-MB-435S Homo sapiens STAT1
STA-21 Western Blot Influence on protein-DNA binding 30.00 µM MDA-MB-435S Homo sapiens STAT5
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens p-STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens p-STAT3
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens STAT3
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 20.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-435S Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM HSF Homo sapiens p-STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MCF7 Homo sapiens p-STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-453 Homo sapiens p-STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens p-STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-453s Homo sapiens p-STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens p-STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM HSF Homo sapiens STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MCF7 Homo sapiens STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-453 Homo sapiens STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-453s Homo sapiens STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens STAT3
STA-21 Western Blot Influence on protein activity 30.00 µM HSF Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MCF7 Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-453 Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-453s Homo sapiens
STA-21 Western Blot Influence on protein activity 30.00 µM MDA-MB-468 Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 20.00 µM MDA-MB-453s Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 30.00 µM MDA-MB-453s Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 20.00 µM MDA-MB-468 Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 30.00 µM MDA-MB-468 Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 20.00 µM MDA-MB-231 Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 30.00 µM MDA-MB-231 Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 20.00 µM MCF7 Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 30.00 µM MCF7 Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 20.00 µM MDA-MB-453 Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 30.00 µM MDA-MB-453 Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 20.00 µM HSF Homo sapiens
STA-21 FACScan Flow Cytometer Influence on cell viability 30.00 µM HSF Homo sapiens