SF-1-088

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT SH2; Non-peptide small molecule
CAS 1241832-83-6

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity. Journal of medicinal chemistry Brent D G Page, Haytham Khoury, Rob C Laister, Steven Fletcher, Megan Vellozo, Alessia Manzoli, Peibin Yue, James Turkson, Mark D Minden, Patrick T Gunning, 55, 3, 2012-02-09, 2012-01-13, 10.1021/jm200720n 10.1021/jm200720n 22148584 22148584

Filter data

Compound SF-1-088
Experiment types RT-PCR, Western Blot
Concentrations 40.00
Cell lines K562
Organisms Homo sapiens
Animal models
STAT proteins STAT5, p-STAT5
Other Cyclin D1, Cyclin D2, GAPDH, Mcl-1, c-Myc

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
SF-1-088 Western Blot Influence on protein activity 40.00 µM K562 Homo sapiens p-STAT5
SF-1-088 Western Blot Influence on protein activity 40.00 µM K562 Homo sapiens STAT5
SF-1-088 Western Blot Influence on protein activity 40.00 µM K562 Homo sapiens
SF-1-088 RT-PCR Influence on trancriptional activity 40.00 µM K562 Homo sapiens
SF-1-088 RT-PCR Influence on trancriptional activity 40.00 µM K562 Homo sapiens
SF-1-088 RT-PCR Influence on trancriptional activity 40.00 µM K562 Homo sapiens
SF-1-088 RT-PCR Influence on trancriptional activity 40.00 µM K562 Homo sapiens