SD-36

Name Value
Weight 0.000 g/mol
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition N/A
CAS 2429877-44-9

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer cell Longchuan Bai, Haibin Zhou, Renqi Xu, Yujun Zhao, Krishnapriya Chinnaswamy, Donna McEachern, Jianyong Chen, Chao-Yie Yang, Zhaomin Liu, Mi Wang, Liu Liu, Hui Jiang, Bo Wen, Praveen Kumar, Jennifer L Meagher, Duxin Sun, Jeanne A Stuckey, Shaomeng Wang, 36, 5, 2019-11-11, None, 10.1016/j.ccell.2019.10.002 10.1016/j.ccell.2019.10.002 31715132 PMC6880868

Filter data

Compound SD-36
Experiment types Flow cytometry- annexin V binding and propidium iodide staining, RT-qPCR, Tumor volume, Western Blot
Concentrations 0.10, 1.00, 10.00, 100.00, 25.00, 50.00
Cell lines MOLM-16, MOLM-16(xenograft), SU-DHL-1, SU-DHL-1(xenograft), SUP-M2, SUP-M2(xenograft)
Organisms Homo sapiens, Mus musculus
Animal models NOD/SCID
STAT proteins STAT1, STAT2, STAT3, STAT4, STAT5, STAT6, p-STAT3(Y705)
Other BCL3, HCK, HGF, JAK3, MYC, PIM1, SOCS3, STAT3, VEGFA, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
SD-36 Western Blot Influence on protein activity 0.10 µM MOLM-16 Homo sapiens STAT3
SD-36 Western Blot Influence on protein activity 1.00 µM MOLM-16 Homo sapiens STAT3
SD-36 Western Blot Influence on protein activity 10.00 µM MOLM-16 Homo sapiens STAT3
SD-36 Western Blot Influence on protein activity 0.10 µM SU-DHL-1 Homo sapiens STAT3
SD-36 Western Blot Influence on protein activity 1.00 µM SU-DHL-1 Homo sapiens STAT3
SD-36 Western Blot Influence on protein activity 10.00 µM SU-DHL-1 Homo sapiens STAT3
SD-36 Western Blot Influence on protein activity 0.10 µM MOLM-16 Homo sapiens STAT1
SD-36 Western Blot Influence on protein activity 1.00 µM MOLM-16 Homo sapiens STAT1
SD-36 Western Blot Influence on protein activity 10.00 µM MOLM-16 Homo sapiens STAT1
SD-36 Western Blot Influence on protein activity 0.10 µM SU-DHL-1 Homo sapiens STAT1
SD-36 Western Blot Influence on protein activity 1.00 µM SU-DHL-1 Homo sapiens STAT1
SD-36 Western Blot Influence on protein activity 10.00 µM SU-DHL-1 Homo sapiens STAT1
SD-36 Western Blot Influence on protein activity 0.10 µM MOLM-16 Homo sapiens STAT2
SD-36 Western Blot Influence on protein activity 1.00 µM MOLM-16 Homo sapiens STAT2
SD-36 Western Blot Influence on protein activity 10.00 µM MOLM-16 Homo sapiens STAT2
SD-36 Western Blot Influence on protein activity 0.10 µM SU-DHL-1 Homo sapiens STAT2
SD-36 Western Blot Influence on protein activity 1.00 µM SU-DHL-1 Homo sapiens STAT2
SD-36 Western Blot Influence on protein activity 10.00 µM SU-DHL-1 Homo sapiens STAT2
SD-36 Western Blot Influence on protein activity 0.10 µM MOLM-16 Homo sapiens STAT4
SD-36 Western Blot Influence on protein activity 1.00 µM MOLM-16 Homo sapiens STAT4
SD-36 Western Blot Influence on protein activity 10.00 µM MOLM-16 Homo sapiens STAT4
SD-36 Western Blot Influence on protein activity 0.10 µM SU-DHL-1 Homo sapiens STAT4
SD-36 Western Blot Influence on protein activity 1.00 µM SU-DHL-1 Homo sapiens STAT4
SD-36 Western Blot Influence on protein activity 10.00 µM SU-DHL-1 Homo sapiens STAT4
SD-36 Western Blot Influence on protein activity 0.10 µM MOLM-16 Homo sapiens STAT5
SD-36 Western Blot Influence on protein activity 1.00 µM MOLM-16 Homo sapiens STAT5
SD-36 Western Blot Influence on protein activity 10.00 µM MOLM-16 Homo sapiens STAT5
SD-36 Western Blot Influence on protein activity 0.10 µM SU-DHL-1 Homo sapiens STAT5
SD-36 Western Blot Influence on protein activity 1.00 µM SU-DHL-1 Homo sapiens STAT5
SD-36 Western Blot Influence on protein activity 10.00 µM SU-DHL-1 Homo sapiens STAT5
SD-36 Western Blot Influence on protein activity 0.10 µM MOLM-16 Homo sapiens STAT6
SD-36 Western Blot Influence on protein activity 1.00 µM MOLM-16 Homo sapiens STAT6
SD-36 Western Blot Influence on protein activity 10.00 µM MOLM-16 Homo sapiens STAT6
SD-36 Western Blot Influence on protein activity 0.10 µM SU-DHL-1 Homo sapiens STAT6
SD-36 Western Blot Influence on protein activity 1.00 µM SU-DHL-1 Homo sapiens STAT6
SD-36 Western Blot Influence on protein activity 10.00 µM SU-DHL-1 Homo sapiens STAT6
SD-36 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell viability 1.00 µM SU-DHL-1 Homo sapiens
SD-36 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell viability 1.00 µM SUP-M2 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM MOLM-16 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM MOLM-16 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM MOLM-16 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM MOLM-16 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM MOLM-16 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM MOLM-16 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM MOLM-16 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM MOLM-16 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM MOLM-16 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM SU-DHL-1 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM SU-DHL-1 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM SU-DHL-1 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM SU-DHL-1 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM SU-DHL-1 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM SU-DHL-1 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM SU-DHL-1 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM SU-DHL-1 Homo sapiens
SD-36 RT-qPCR Influence on mRNA expression level 1.00 µM SU-DHL-1 Homo sapiens
SD-36 Western Blot Influence on protein activity in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID p-STAT3(Y705)
SD-36 Western Blot Influence on protein activity in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID STAT3
SD-36 Western Blot Influence on protein activity in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 Tumor volume Influence on cell proliferation in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 Tumor volume Influence on cell proliferation in tumor tissue 50.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 Tumor volume Influence on cell proliferation in tumor tissue 100.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 Tumor volume Influence on cell proliferation in tumor tissue 25.00 mg/kg SU-DHL-1(xenograft) Mus musculus NOD/SCID
SD-36 Tumor volume Influence on cell proliferation in tumor tissue 50.00 mg/kg SU-DHL-1(xenograft) Mus musculus NOD/SCID
SD-36 Tumor volume Influence on cell proliferation in tumor tissue 100.00 mg/kg SU-DHL-1(xenograft) Mus musculus NOD/SCID
SD-36 Tumor volume Influence on cell proliferation in tumor tissue 25.00 mg/kg SUP-M2(xenograft) Mus musculus NOD/SCID
SD-36 Tumor volume Influence on cell proliferation in tumor tissue 50.00 mg/kg SUP-M2(xenograft) Mus musculus NOD/SCID
SD-36 Tumor volume Influence on cell proliferation in tumor tissue 100.00 mg/kg SUP-M2(xenograft) Mus musculus NOD/SCID
SD-36 RT-qPCR Influence on mRNA expression level in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 RT-qPCR Influence on mRNA expression level in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 RT-qPCR Influence on mRNA expression level in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 RT-qPCR Influence on mRNA expression level in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 RT-qPCR Influence on mRNA expression level in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 RT-qPCR Influence on mRNA expression level in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 RT-qPCR Influence on mRNA expression level in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID
SD-36 RT-qPCR Influence on mRNA expression level in tumor tissue 25.00 mg/kg MOLM-16(xenograft) Mus musculus NOD/SCID