SC-1.SC-49

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition STAT, SHP1; Tyrosine kinase inhibitor
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Sorafenib and its derivative SC-49 sensitize hepatocellular carcinoma cells to CS-1008, a humanized anti-TNFRSF10B (DR5) antibody. British journal of pharmacology Kuen-Feng Chen, Hui-Ling Chen, Chung-Wai Shiau, Chun-Yu Liu, Pei-Yi Chu, Wei-Tien Tai, Kimihisa Ichikawa, Pei-Jer Chen, Ann-Lii Cheng, 168, 3, None, None, 10.1111/j.1476-5381.2012.02212.x 10.1111/j.1476-5381.2012.02212.x 22978563 PMC3579286

Filter data

Compound SC-1.SC-49
Experiment types ELISA, Western Blot
Concentrations 10.00, 12.50, 2.50, 5.00, 7.50
Cell lines Hep3B, Huh-7, PLC5, U937
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, STAT5, p-STAT1, p-STAT3, p-STAT5
Other Actin, Bid, Caspase-3, Caspase-8, Caspase-9, Cyclin D1, PARP, Survivin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
SC-1.SC-49 ELISA Influence on cell apoptosis 2.50 µM PLC5 Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 5.00 µM PLC5 Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 2.50 µM Hep3B Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 5.00 µM Hep3B Homo sapiens
SC-1.SC-49 Western Blot Influence on cell apoptosis 5.00 µM PLC5 Homo sapiens
SC-1.SC-49 Western Blot Influence on cell apoptosis 5.00 µM PLC5 Homo sapiens
SC-1.SC-49 Western Blot Influence on cell apoptosis 5.00 µM PLC5 Homo sapiens
SC-1.SC-49 Western Blot Influence on cell apoptosis 5.00 µM PLC5 Homo sapiens
SC-1.SC-49 Western Blot Influence on cell apoptosis 5.00 µM PLC5 Homo sapiens
SC-1.SC-49 Western Blot Influence on cell apoptosis 5.00 µM PLC5 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM PLC5 Homo sapiens p-STAT1
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM PLC5 Homo sapiens p-STAT1
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM PLC5 Homo sapiens p-STAT1
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM PLC5 Homo sapiens p-STAT1
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM PLC5 Homo sapiens STAT1
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM PLC5 Homo sapiens STAT1
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM PLC5 Homo sapiens STAT1
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM PLC5 Homo sapiens STAT1
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM PLC5 Homo sapiens p-STAT5
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM PLC5 Homo sapiens p-STAT5
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM PLC5 Homo sapiens p-STAT5
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM PLC5 Homo sapiens p-STAT5
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM PLC5 Homo sapiens STAT5
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM PLC5 Homo sapiens STAT5
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM PLC5 Homo sapiens STAT5
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM PLC5 Homo sapiens STAT5
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM PLC5 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM PLC5 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM PLC5 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM PLC5 Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 2.50 µM Huh-7 Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 5.00 µM Huh-7 Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 7.50 µM Huh-7 Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 10.00 µM Huh-7 Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 12.50 µM Huh-7 Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 7.50 µM Hep3B Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 10.00 µM Hep3B Homo sapiens
SC-1.SC-49 ELISA Influence on cell apoptosis 12.50 µM Hep3B Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM Huh-7 Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM Huh-7 Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM Huh-7 Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM Huh-7 Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM Huh-7 Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM Huh-7 Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM Huh-7 Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM Huh-7 Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM Huh-7 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM Huh-7 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM Huh-7 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM Huh-7 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM Hep3B Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM Hep3B Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM Hep3B Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM Hep3B Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM Hep3B Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM Hep3B Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM U937 Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM U937 Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM U937 Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM U937 Homo sapiens p-STAT3
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM U937 Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM U937 Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM U937 Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM U937 Homo sapiens STAT3
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 2.50 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 5.00 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 7.50 µM U937 Homo sapiens
SC-1.SC-49 Western Blot Influence on protein activity 10.00 µM U937 Homo sapiens