SAR317461

Name Value
Weight 509.680 g/mol
Zinc ID ZINC000063539888
Smiles Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1
Molecular formula C26H35N7O2S
Mode of inhibition JAK2; Tyrosine kinase inhibitor
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres. Journal of translational medicine Rajesh Mukthavaram, Xiao Ouyang, Rohit Saklecha, Pengfei Jiang, Natsuko Nomura, Sandeep C Pingle, Fang Guo, Milan Makale, Santosh Kesari, 13, None, 2015-08-18, 2015-08-18, 10.1186/s12967-015-0627-5 10.1186/s12967-015-0627-5 26283544 PMC4539675

Filter data

Compound SAR317461
Experiment types Alamar Blue assay, Flow cytometry- annexin V binding and propidium iodide staining, Western Blot
Concentrations 0.10, 10.00, 2.00, 25.00, 40.00
Cell lines A172, Enriched CD138+, GBM4, GBM8, SK1035, SK262, SK429, SK892, SK987, U251, U87
Organisms Homo sapiens
Animal models
STAT proteins STAT3, STAT5, p-STAT3, p-STAT5
Other Bcl-xL, GAPDH, PARP

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
SAR317461 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoposis in presence of Thalidomide 25.00 µM Enriched CD138+ Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM SK1035 Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM SK987 Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM SK892 Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM GBM4 Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM GBM8 Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM SK262 Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM SK429 Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM U87 Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM A172 Homo sapiens
SAR317461 Alamar Blue assay Influence on cell proliferation 40.00 µM U251 Homo sapiens
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM4 Homo sapiens p-STAT3
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM4 Homo sapiens p-STAT3
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM4 Homo sapiens p-STAT3
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM8 Homo sapiens p-STAT3
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM8 Homo sapiens p-STAT3
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM8 Homo sapiens p-STAT3
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM4 Homo sapiens STAT3
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM4 Homo sapiens STAT3
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM4 Homo sapiens STAT3
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM8 Homo sapiens STAT3
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM8 Homo sapiens STAT3
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM8 Homo sapiens STAT3
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM4 Homo sapiens p-STAT5
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM4 Homo sapiens p-STAT5
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM4 Homo sapiens p-STAT5
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM8 Homo sapiens p-STAT5
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM8 Homo sapiens p-STAT5
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM8 Homo sapiens p-STAT5
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM4 Homo sapiens STAT5
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM4 Homo sapiens STAT5
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM4 Homo sapiens STAT5
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM8 Homo sapiens STAT5
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM8 Homo sapiens STAT5
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM8 Homo sapiens STAT5
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM4 Homo sapiens
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM4 Homo sapiens
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM4 Homo sapiens
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM8 Homo sapiens
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM8 Homo sapiens
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM8 Homo sapiens
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM4 Homo sapiens
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM4 Homo sapiens
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM4 Homo sapiens
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM8 Homo sapiens
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM8 Homo sapiens
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM8 Homo sapiens
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM4 Homo sapiens
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM4 Homo sapiens
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM4 Homo sapiens
SAR317461 Western Blot Influence on protein activity 0.10 µM GBM8 Homo sapiens
SAR317461 Western Blot Influence on protein activity 2.00 µM GBM8 Homo sapiens
SAR317461 Western Blot Influence on protein activity 10.00 µM GBM8 Homo sapiens
SAR317461 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 2.00 µM GBM8 Homo sapiens
SAR317461 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 2.00 µM GBM4 Homo sapiens