S31-201.1066/ SF-1066

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT SH2; Non-peptide small molecule
CAS N/A

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
[Diagnostic importance of the Holter ECG monitoring of miners under industrial conditions]. Vrachebnoe delo V V Cherkesov, R A Kopytina, T V Kudinova, None, 7, None, None, 10.1016/j.bcp.2010.01.001 10.1016/j.bcp.2010.01.001 3188443 PMC3188443

Filter data

Compound S31-201.1066/ SF-1066
Experiment types CyQuant cell proliferation kit, EMSA, Tumor volume, Western Blot, Wound healing assay
Concentrations 100.00, 150.00, 200.00, 3.00, 30.00, 50.00, 80.00
Cell lines A2780S, HPDEC, MDA-MB-231, MDA-MB-231(xenograft), NIH3T3/hEGFR, NIH3T3/v-Ras, NIH3T3/v-Src, Panc-1, null mouse embryonic fibroblasts (Stat3-/-)
Organisms Homo sapiens, Mus musculus
Animal models athymic nude mice
STAT proteins STAT1:STAT1, STAT1:STAT3, STAT3, STAT3:STAT3, p-STAT3, p-STAT3(Y705)
Other Bcl-xL, ERK1/2, MMP-9, SHC46, SHC52, SRC, Survivin, VEGF, c-Myc, p-ERK1/2, p-SHC46, p-SHC52, p-SRC(Y416), β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 30.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 80.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 100.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 50.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 200.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 50.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 100.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 200.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 50.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 100.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 200.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 30.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 50.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 100.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 150.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 30.00 µM Panc-1 Homo sapiens STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 50.00 µM Panc-1 Homo sapiens STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 100.00 µM Panc-1 Homo sapiens STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 150.00 µM Panc-1 Homo sapiens STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 30.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 50.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 100.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S31-201.1066/ SF-1066 EMSA Influence on protein-DNA binding 150.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus p-STAT3(Y705)
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus p-STAT3(Y705)
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus p-STAT3(Y705)
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens p-STAT3(Y705)
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens p-STAT3(Y705)
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens p-STAT3(Y705)
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens STAT3
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 30.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 100.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 30.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 100.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 30.00 µM A2780S Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 50.00 µM A2780S Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 100.00 µM A2780S Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 30.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 100.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 30.00 µM NIH3T3/v-Ras Mus musculus
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 50.00 µM NIH3T3/v-Ras Mus musculus
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 100.00 µM NIH3T3/v-Ras Mus musculus
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 30.00 µM HPDEC Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 50.00 µM HPDEC Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 100.00 µM HPDEC Homo sapiens
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 30.00 µM null mouse embryonic fibroblasts (Stat3-/-) Mus musculus
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 50.00 µM null mouse embryonic fibroblasts (Stat3-/-) Mus musculus
S31-201.1066/ SF-1066 CyQuant cell proliferation kit Influence on cell viability 100.00 µM null mouse embryonic fibroblasts (Stat3-/-) Mus musculus
S31-201.1066/ SF-1066 Wound healing assay Influence on cell motility 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Wound healing assay Influence on cell motility 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Wound healing assay Influence on cell motility 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Wound healing assay Influence on cell motility 50.00 µM NIH3T3/v-Ras Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM NIH3T3/v-Src Mus musculus
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM MDA-MB-231 Homo sapiens
S31-201.1066/ SF-1066 Western Blot Influence on protein activity 50.00 µM Panc-1 Homo sapiens
S31-201.1066/ SF-1066 Tumor volume Influence on cell proliferation in tumor tissue 3.00 mg/kg MDA-MB-231(xenograft) Mus musculus athymic nude mice
S31-201.1066/ SF-1066 Tumor volume Influence on cell proliferation in tumor tissue 3.00 mg/kg MDA-MB-231(xenograft) Mus musculus athymic nude mice
S31-201.1066/ SF-1066 Tumor volume Influence on cell proliferation in tumor tissue 3.00 mg/kg MDA-MB-231(xenograft) Mus musculus athymic nude mice
S31-201.1066/ SF-1066 Tumor volume Influence on cell proliferation in tumor tissue 3.00 mg/kg MDA-MB-231(xenograft) Mus musculus athymic nude mice
S31-201.1066/ SF-1066 Tumor volume Influence on cell proliferation in tumor tissue 3.00 mg/kg MDA-MB-231(xenograft) Mus musculus athymic nude mice
S31-201.1066/ SF-1066 Tumor volume Influence on cell proliferation in tumor tissue 3.00 mg/kg MDA-MB-231(xenograft) Mus musculus athymic nude mice p-STAT3
S31-201.1066/ SF-1066 Tumor volume Influence on cell proliferation in tumor tissue 3.00 mg/kg MDA-MB-231(xenograft) Mus musculus athymic nude mice STAT3