Pravastatin

Name Value
Weight 424.534 g/mol
Zinc ID ZINC3798763
Smiles CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@H]21
Molecular formula C23H36O7
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS 81093-37-0

Clinical Trials

Study title Status Conditions Link
Pravastatin to Prevent Preeclampsia Recruiting Preeclampsia|Obstetric Labor Complications|Hypertension in Pregnancy NCT03944512
Indonesia Pravastatin to Prevent Preeclampsia Study Recruiting Pre-Eclampsia NCT03648970
Pravastatin for Prevention of Preeclampsia Active, not recruiting Preeclampsia NCT01717586
Effect of Pravastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease Completed Chronic Kidney Disease NCT02992548
Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes Completed Diabetes Mellitus|Prediabetic State NCT02754739
Drug-Drug Interaction Study With Pravastatin and Cyclosporine Completed Healthy NCT01497483
Pravastatin Intervention to Delay Hepatocellular Carcinoma Recurrence Recruiting Hepatocellular Carcinoma|Liver Cirrhoses NCT03219372
Effect of GDC-0810 on the Pharmacokinetics of Pravastatin in Healthy Female Subjects of Non-Childbearing Potential Completed Breast Cancer NCT02621957
Effects of Pravastatin on Cholesterol, Inflammation and Cognition in Schizophrenia Completed Schizophrenia|Schizoaffective Disorders|Schizophreniform Disorders NCT01082588
Single Dose Pravastatin Pharmacokinetics in Pediatric Peritoneal Dialysis Patients Terminated End Stage Renal Disease NCT00571194
Pravastatin 80 mg Tablets Dosed in Healthy Subjects Under Non-Fasting Conditions Completed Healthy NCT00829309
A Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria Completed Progeria|Hutchinson-Gilford Syndrome NCT00879034
A Drug-Drug Interaction Study Between AZD1981 and Pravastatin to Study the Effect of AZD1981 on the Kinetics of Pravastatin Completed Drug Interaction NCT01254461
Bioequivalence Study of Pravastatin Sodium Tablets 80 mg Under Fed Conditions Completed Healthy NCT01146093
Study to Evaluate the Efficacy of Pravastatin on Survival and Recurrence of Advanced Gastroesophageal Cancer Unknown status Esophageal Cancer|Stomach Cancer NCT01038154
Bioequivalence Study of Pravastatin Sodium Tablets 80 mg Under Fasting Conditions Completed Healthy NCT01146106
Efficacy and Safety Study of Sorafenib Plus Pravastatin to Treat Advanced Hepatocarcinoma Completed Advanced Hepatocarcinoma NCT01418729
A Study to Evaluate Daily Pravastatin, Fenofibrate or Pravafen in the Treatment of Combined Hyperlipidemia Completed Combined Hyperlipidemia NCT00459745
The Effects of Pravastatin and Rosuvastatin on Coronary Plaques in Patients With Stable Angina Pectoris Unknown status Coronary Disease|Hypercholesterolemia NCT01325818
The Influence of Raltegravir on Pravastatin Pharmacokinetics(GRAPPA) Completed HIV Infections NCT00665717
Genetic Predictors of Variability in the Drug-drug Interaction Between Darunavir/Ritonavir and Pravastatin Completed HIV Infections|Hyperlipidemia NCT00630734
Pravastatin Sodium 80 mg Tablets Under Fasting Conditions Completed Healthy NCT00830258
Curative Efficacy of Pravastatine in Patients Presented Delayed Cutaneous and Subcutaneous Radio-induced Fibrosis Completed Fibrosis NCT01268202
Treatment of the Hutchinson-Gilford Progeria Syndrome With a Combination of Pravastatin and Zoledronic Acid Completed Hutchinson-Gilford Progeria Syndrome NCT00731016
Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease Recruiting Autosomal Dominant Polycystic Kidney Disease NCT04284657
Statins: A New Therapeutic Option for Treatment of Patients With Endometriosis Withdrawn Endometriosis NCT02079974
Pravastatin and Ventilatory Associated Pneumonia Completed Ventilator Associated Pneumonia NCT00702130
Pravastatin or Atorvastatin Evaluation and Infection Therapy (TIMI22) Completed Actue Coronary Syndromes NCT00382460
A Trial Comparing the Effect of Pravastatin and Rosuvastatin on Atherosclerosis Progression Measured by Carotid Intima Media Thickness in Patients With Coronary Artery Disease After Biolimus Eluting Stent (Nobori®) Implantation: CPR IMT Completed Coronary Artery Occlusive Disease NCT01872845
Statin Adjunctive Therapy for TB (StAT- TB) Not yet recruiting Tuberculosis NCT03456102
Idarubicin, Cytarabine, and Pravastatin Sodium in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13 NCT01831232
Cyclosporine, Pravastatin Sodium, Etoposide, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Terminated Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13 NCT01342887
Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria Enrolling by invitation Progeria NCT00916747
Fed, Bioequivalence Study of Pravastatin Sodium 80 mg Tablets Versus Pravachol® 80 mg Tablets In Subjects Completed Therapeutic Equivalency NCT00648544
A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Pravastatin for at Least 4 Weeks. Completed Hypercholesterolemia NCT00755352
Fasting Bioequivalence Study of Pravastatin Sodium 80 mg Tablets Versus Pravachol® 80 mg Tablets In Normal Healthy Subjects Completed Therapeutic Equivalency NCT00650221
A Study of Evacetrapib in Japanese and Non-Japanese Participants Completed Healthy Volunteers NCT01958489
Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin Completed Drug Interaction Potentiation NCT03801733
A Study Comparing the Mechanisms of Action of Lifibrol and Pravastatin Completed Hypercholesterolemia|Hyperlipoproteinemia NCT01057654
Pravastatin for Acute Myocardial Infarction With Minimally to Mildly Increased Levels of Serum Cholesterol Study Unknown status Acute Myocardial Infarction NCT00688922
Pravastatin Sodium 40 mg Tablets Food Challenge Study Completed Healthy NCT00834847
Clinical Trial to Evaluate the Efficacy and Safety of Pravafenix Cap to Verify the Superiority Than Atorvastatin Completed Combined Dyslipidemia NCT02166593
Prevail-Us: A Study Of Pitavastatin 4 mg Vs. Pravastatin 40 mg In Patients With Primary Hyperlipidemia Or Mixed Dyslipidemia Completed Primary Dyslipidemia|Mixed Dyslipidemia NCT01256476
A Study of the PK Interaction of CXA-10 With Pravastatin and Vytorin® in Healthy Males Completed Acute Kidney Injury NCT02547402
Sorafenib Tosylate With or Without Pravastatin in Treating Patients With Liver Cancer and Cirrhosis Completed Liver Cancer NCT01075555
StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With Tuberculosis Recruiting Tuberculosis|Pulmonary Tuberculosis NCT03882177
Type II Diabetes Mellitus in Patients Exposed to Pravastatin and Paroxetine Completed Depression, Postpartum NCT01602913
Statin Distribution Completed Drug Distribution NCT02360826
Pravastatin Therapy in Patients With Active Crohn's Disease: A Pilot Study Unknown status Crohn's Disease NCT00599625
Randomized Trial Sorafenib-Pravastatin Versus Sorafenib Alone for the Palliative Treatment of Child-Pugh A Hepatocellular Carcinoma Completed Child-Pugh A Hepatocellular Carcinoma NCT01903694
Efficacy and Safety Study of JTT-705 in Combination With Pravastatin 40 mg in Patients With Type II Hyperlipidemia Completed Type II Hyperlipidemia NCT00688896
Rosuvastatin Versus Pravastatin in HIV Patients Treated With Boosted Protease Inhibitors (PI) (ANRS126) Completed Hyperlipidemia|HIV Infections NCT00117494
Pravastatin and Protease Inhibitors in HIV-Infected Patients Completed HIV Infection|Hypercholesterolemia NCT00221754
Pravastatin for Hyperlipidaemia in HIV. Completed HIV Infections|Lipid Metabolism|Glucose Metabolism|Metabolic Abnormality|Lipodystrophy|Cardiovascular Disease NCT00227500
Coadministration of Ezetimibe With Fenofibrate Versus Pravastatin Monotherapy for the Treatment of Hyperlipidaemia in HIV-infected Patients Unknown status HIV|Hyperlipidemia|HIV Infections NCT00843661
Pravastatin Efficacy and Safety Trial in Hypercholesterolemic Patients With Chronic Liver Disease Completed Hypercholesterolemia NCT00529178
Improving Symptoms of Schizophrenia and Schizoaffective Disorder by Supplementing Medications With Pravastatin Completed Schizophrenia|Schizoaffective Disorder NCT00177580
Study to Compare the Efficacy and Safety of Pitavastatin and Pravastatin in Elderly Patients Completed Hypercholesterolemia or Combined Dyslipidemia NCT00257686
A 12-Week Study Comparing Pitavastatin 4 mg vs. Pravastatin 40 mg in HIV-Infected Subjects Completed Dyslipidemia NCT01301066
Bioavailability Study of Pravastatin Sodium 40 mg Tablets Under Fasting Conditions Completed Healthy NCT00834379
Comparison of the Combination of Fenofibrate and Simvastatin Versus Pravastatin Completed Hyperlipidemia NCT00362206
Additive Effects of Pravastatin and Valsartan Completed Hypertension|High Cholesterol NCT01004237
Lipid Lowering Agents to Limit Lipid Oxidation and Activation of Clotting System in Nephrotic Syndrome Completed Nephrotic Syndrome|Hyperlipidemia NCT01845428
S0919 Idarubicin, Cytarabine, and Pravastatin in Treating Patients With Relapsed Acute Myeloid Leukemia Active, not recruiting Leukemia NCT00840177
Safety of Red Yeast Rice for High Cholesterol in Individuals With Statin Intolerance Completed Hypercholesterolemia|Statin-Associated Myopathy NCT00639223
Safety and Effectiveness of Fenofibrate and Pravastatin in HIV-Positive Patients With Abnormal Blood Lipids Completed HIV Infections|Lipodystrophy NCT00006412
Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients Completed Type IIa and IIb Hypercholesterolaemia NCT00631189
Influence of Pravastatin on Carotid Artery Structure and Function in HIV-infected Patients Under Antiretroviral Therapy Completed HIV Infection|Carotid Atherosclerosis|Dyslipidemia NCT00147797
Effects of Atorvastatin Versus Pravastatin on Platelet Inhibition by Clopidogrel Completed Ischemic Heart Disease|Acute Coronary Syndromes NCT00405717
Pravastatin, Idarubicin, and Cytarabine in Treating Patients With Acute Myeloid Leukemia Completed Leukemia NCT00107523
Monitoring and Treatment of Relapsed Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation in Children Active, not recruiting Leukemia NCT02484261
STELLAR-Rosuvastatin vs. Atorvastatin, Pravastatin, Simvastatin Across Dose Ranges Completed Hypercholesterolemia NCT00654537
Safety and Efficacy of Pravastatin in Relapsing-remitting Multiple Sclerosis Completed Relapsing-remitting Multiple Sclerosis NCT00200655
Statin Therapy in Patients With Early Stage ADPKD Recruiting ADPKD|Autosomal Dominant Polycystic Kidney NCT03273413
Study to Evaluate the Effect of SCY-078 (Ibrexafungerp) on the PK of Pravastatin in Healthy Subjects Not yet recruiting Pharmacokinetics NCT04092751
Etoposide and Cisplatin or Carboplatin as First-Line Chemotherapy With or Without Pravastatin in Treating Patients With Small Cell Lung Cancer Completed Lung Cancer NCT00433498
Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells Completed Diabetes Mellitus|Metabolic Syndrome X|Hypercholesterolemia NCT00166036
Pharmacodynamics, Preliminary Pharmacokinetics and Tolerability of BIBB 515 BS or Pravastatin in Hyperlipemic Healthy Male Subjects Completed Healthy NCT02266485
Yokohama Assessment of Fluvastatin, Pravastatin, Pitavastatin and Atorvastatin in Acute Coronary Syndrome (Yokohama-ACS) Completed Coronary Disease|Hypercholesterolemia NCT00549926
Study to Investigate the Effect of BMS-986142 on the Pharmacokinetics (PK) of Methotrexate and Probe Substrate Cocktail in Healthy Patients Completed Rheumatoid Arthritis NCT02456844
This Study Uses Ultrasound to Determine Whether Atorvastatin or Pravastatin Effects the Progression of Coronary Plaque. Completed Coronary Arteriosclerosis NCT00380939
Effect of Pravastatin on Endothelial Dysfunction Following a Single High Fat Meal Unknown status Heart Diseases NCT00005117
Cilostazol-Simvastatin Drug Interaction Study Unknown status Dyslipidemias|Peripheral Artery Disease NCT02431013
COmparison and Modification in Neointimal Pattern Assessed by Optical Coherence Tomography With High Versus Moderate Efficacy Statin Treatment After Drug Eluting Stent Implantation: COMPASS Trial Completed Coronary Artery Disease NCT02155530
The Statins on Glucose Homeostasis in Subjects With Impaired Fasting Glucose Recruiting Diabetes NCT01816997
Palliative Treatment of Hepatocellular Carcinoma in Patient With CHILD B Cirrhosis Completed Hepatocellular Carcinoma|CHILD B NCT01357486
Effect of Statin Therapy on Disease Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Completed Polycystic Kidney, Autosomal Dominant NCT00456365
Japan Statin Treatment Against Recurrent Stroke (J-STARS) Completed Ischemic Stroke NCT00221104
Efficacy and Safety of BMS-298585 Alone or in Combination With Pravastatin in Subjects With Mixed Dyslipidemia Completed Dyslipidemia NCT00245388
Differential Metabolic Effects of Statins Completed Hypercholesterolemia NCT00546559
Type III Dysbetalipoproteinemia Completed Hyperlipoproteinemia Type III NCT00214604
Prevention of Renal and Vascular Endstage Disease Intervention Trial Completed Microalbuminuria|Cardiovascular Diseases|Renal Disease NCT03073018
Aspirin Mono Therapy 12-months After Drug-eluting Stents Implantation Unknown status Drug-eluting Stent (DES) NCT01557075
Effect of HAART Vs. Statin Treatment on Endothelial Function and Inflammation/Coagulation Withdrawn HIV-1 Infection NCT01515813
Different Metabolic Effects of Statins Completed Hypercholesterolemia NCT01011127
Effect of Statin Use on Aldosterone Secretion Recruiting Healthy Subjects NCT02871687
Study to Determine the Potential DDIs When the Daclatasvir/Asunaprevir/BMS-791325 Three Drug Antiviral Combination Tablet (FDC) is Coadministered With a Cocktail of Cytochrome P450 (CYP) Probe Substrates and Transporter Probe Substrates (Digoxin and Pravastatin) in Healthy Subjects Completed Hepatitis C NCT02045966
South Korean Pitavastatin Heart Failure Study Completed Chronic Heart Failure NCT00701285
Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study Terminated Chronic Kidney Disease NCT00384618
Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin Completed Rheumatoid Arthritis NCT03131973
Do HMG CoA Reductase Inhibitors Affect Abeta Levels? Completed Alzheimer's Disease|Aging NCT00303277
Combination Effects of High-dose Statin and Trimetazidine on Patients With Aspirin Mono Antiplatelet Therapy 12-months After Coronary Artery Bypass Surgery Completed Coronary Artery NCT01857921
High Intensity Lipid Lowering Following Acute Coronary Syndromes for Persons Living With HIV Recruiting HIV Infection|Coronary Heart Disease NCT02841774
A Study to Assess the Effect of RO4607381 in Patients With Relatively Low Levels of High Density Lipoprotein-Cholesterol (HDL-C) Completed Dyslipidemia NCT00697203
Longitudinal Study of Multi-Analyte Profile for Dyslipidemia Unknown status Dyslipidemia NCT01441908
Cardiovascular Prevention for Persons With HIV Completed HIV Infection|Cardiovascular Disease Risk NCT00982189
Drug-Drug Interaction Study With PF-05089771 Completed Healthy NCT01934569
Primary Prevention of Major Adverse Cardiac Events (MACE) With Standard and Intensive Statin Treatment in Patients With Diabetes: Survival and Cardiovascular Event Assessments Terminated Hypercholesterolemia|Type 2 Diabetes|Hypertension NCT01173939
Comparison of Ezetimibe Added to Ongoing Statin Therapy Versus Doubling the Dose of Statin in the Treatment of Hypercholesterolemia (P04355) Completed Hypercholesterolemia NCT00652327
Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA Study) Completed Hyperlipidemia NCT00211705
Statins and the Urinary Proteome Completed Statin Induced Proteinuria NCT00464503
Carotid Intima-media Thickness in Japan Statin Treatment Against Recurrent Stroke(J-STARS Echo) Completed Ischemic Stroke NCT00361530
Pharmacodynamics, Preliminary Pharmacokinetics and Tolerability of BIBB 1464 (Tablet) in Hyperlipemic Healthy Male Subjects Completed Healthy NCT02229773
Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome Terminated Hermansky-Pudlak Syndrome (HPS)|Pulmonary Fibrosis|Oculocutaneous Albinism|Platelet Storage Pool Deficiency|Metabolic Disease NCT00467831
Prevention of Kidney Transplant Rejection Completed End-Stage Renal Disease|Chronic Allograft Nephropathy NCT00005010
Cardiovascular Risk Markers and Response to Statins After Kawasaki Disease Withdrawn Kawasaki Disease NCT00305201
Study on Effects of BMS-955176 on the Pharmacokinetics of Probe Substrates Completed HIV Infections NCT02578277
Vytorin on Carotid Intima-media Thickness and Overall Rigidity Completed Cardiovascular Diseases NCT00738296
Early Effects of Intensive Lipid Lowering Treatment With Ezetimibe/ Simvastatin (Vytorin®) Assessed by Virtual Histology-Intravascular Ultrasound (VH-IVUS) and Optical Coherence Tomography (OCT) on Plaque Characteristics in Patients With Acute Coronary Syndrome Completed Acute Coronary Syndrome NCT01857843
AuTophagy Activation for Cardiomyopathy Due to Anthracycline tReatment (ATACAR)Trial Not yet recruiting Lymphoma NCT04190433
Endothelial Dysfunction as a Risk Factor in HIV Study Completed HIV Infections NCT00039663
Open Label Study for the Functional Characterization of Drug Metabolism and Transport Completed Genotype-related Drug Metabolism NCT01788254
hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP) Completed Ischemic Stroke NCT00361699
Effects of Statin Medications on Mental Processes, Behavior, and Serotonin Levels Completed Dyslipidemias NCT00330980
The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugs Completed HIV Infections|HIV Seronegativity|Lipodystrophy NCT00017758
Quality of Life in Patients With Statin-Associated Myopathy Terminated Statin Adverse Reaction NCT00850460
Serial EValuation of multiplE Coronary Artery Diseases by an Optical Coherence Tomography N/A N/A NCT01856374
Left Ventricular Hypertrophy Reduction With Statins in Hypertensives Patients (MK0653A-168) Terminated Hypertension NCT00738972
Evaluation of Myocardial Improvement in Patients Supported by Ventricular Assist Device Under Optimal Pharmacological Therapy Terminated Heart Failure NCT00402376
Naturopathic Treatment for the Prevention of Cardiovascular Disease Completed Cardiovascular Disease NCT00718796
Efficacy and Safety of Prescription Omega-3 Fatty Acid Added to Stable Statin Therapy in Patients With Type 2 Diabetes and Hypertriglyceridemia Completed Diabetes Mellitus, Type 2|Hypertriglycemia NCT02305355
Statin Recapture Therapy Before Coronary Artery Bypass Grafting Completed Coronary Artery Disease NCT01715714
Aggressive Treatment of Metabolic Syndrome in Patients Receiving Clozapine for Schizophrenia Terminated Metabolic Syndrome NCT00794963
Observational Study of Approaches to Lipid-Lowering Therapy in Russian Patients With Coronary Heart Disease <<Treat to Goal>> (Study P05464) Completed Coronary Heart Disease|Hypercholesterolemia NCT00730132
A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood Completed HIV Infections NCT00000941
Repeated Dose Study for the Investigation of Heritability of and Genetic Influences on Drug Pharmacokinetics Completed Drug Biotransformation|Membrane Transport NCT01845194
Statin Interchange by Pharmacist Collaborative Practice Agreement (CPA) Completed Hypercholesterolemia NCT01222182
Neointimal Coverage After Implantation of Biolimus Eluting Stent With Biodegradable Polymer: Optical Coherence Tomographic Assessment According to the Treatment of Dyslipidemia and Hypertension and the Types of Implanted Drug-eluting Stents Completed Stable Angina or Acute Coronary Syndrome Considered for Percutaneous Coronary Intervention With Dyslipidemia or Hypertension NCT01502904
High Potency Statins and Acute Kidney Injury Completed Hypercholesterolemia NCT02518516
High Potency Statins and the Risk of Diabetes Completed Diabetes Mellitus, Type 2|Cardiovascular Disease NCT02518503
Pitavastatin on Carotid Intima-media Thickness Unknown status Hyperlipidemia|Carotid Artery Diseases NCT00711919
Fluvastatin in Adults With Dislipidemia With History of Muscle Problems Completed Dyslipidemia NCT00125125
Efficacy and Safety of Colesevelam in Pediatric Patients With Genetic High Cholesterol Completed Hypercholesterolemia NCT00145574
Prevention of Atherosclerosis and Heart Disease in Patients With Systemic Lupus Erythematosis (SLE) Completed Systemic Lupus Erythematosus|Lupus NCT00054938
High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly Completed Atherosclerosis|Cardiovascular Disease NCT00127218
To Explore the Treatment Effect of Various Commercially Available Statins on Patients With Hyperlipidemia Completed Hyperlipidemias NCT00726362
Evaluation of the Efficacy of Rosuvastatin in Daily Practice (TARGET) Completed Hypercholesterolemia|Coronary Heart Disease NCT00396110
The Triglyceride Lowering Effect of an Omega-3 Fat (DHA) in Addition to Statin Therapy for Patients With CAD or Diabetes Completed Hypertriglyceridemia (TG>200<500)|Hyperlipidemia|Coronary Artery Disease|Coronary Risk Equivalent|Diabetes NCT00360217
Harvard Atherosclerosis Reversibility Project (HARP) Completed Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Ischemia NCT00000461
Ekvasis of Atorvastatin (Antorcin®) Treatment in Patients With Acute Cardiovascular Events Completed Cardiovascular Disorders NCT01770210
Effect of Pitavastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease Unknown status Chronic Kidney Disease NCT02863185
Efficacy and Safety of PRC-4016 in Subjects With Mixed Dyslipidemia Terminated Dyslipidemia NCT01972178
Erythrocyte-bound Apolipoprotein B After Withdrawal of Statin Therapy Completed Hyperlipidemia|Atherosclerosis NCT01634906
Effect of Succinylcholine on Patients Using Statins Completed Pain NCT00986583
Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa Not yet recruiting Hidradenitis Suppurativa NCT03929835
Evaluation of Patients With Statin Myopathy Using an N of 1 Trial Design Completed Statin Myopathy NCT01259791
A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients Recruiting Prostate Cancer|Cardiovascular Disease NCT03127631
Clinical Study to Evaluate Adherence Improvement Fixed-dose Combination of Olostar Tab. in Patients With Hypertension and Dyslipidemia Completed Hypertension|Dyslipidemias NCT04061824
Role of Hydroxychloroquine to Improve Endothelial Dysfunction in Patients With Rheumatoid Arthritis Completed Rheumatoid Arthritis NCT03085940
Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy (ODYSSEY JAPAN) Completed Hypercholesterolemia NCT02107898
Arterial Disease Multifactorial Intervention Trial (ADMIT) Completed Arterial Occlusive Diseases|Cardiovascular Diseases|Heart Diseases|Vascular Diseases|Diabetes Mellitus NCT00000539
Evaluation of ETC-1002 vs Placebo in Patients Receiving Ongoing Statin Therapy Completed Hypercholesterolemia NCT02072161
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Completed Cardiovascular Diseases|Coronary Disease|Diabetes Mellitus|Heart Diseases|Hypercholesterolemia|Hypertension|Myocardial Infarction|Myocardial Ischemia|Heart Failure NCT00000542
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia Recruiting Hypercholesterolaemia NCT03510884
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia Completed Hypercholesterolemia NCT03510715
A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808) Completed Hypercholesterolemia NCT00132717
Intensive Statin Treatment in Chinese Coronary Artery Disease Patients Undergoing PCI Completed Non-ST Segment Elevation Myocardial Infarction|Unstable Angina Pectoris|Stable Angina Pectoris NCT01293097
Efficacy of Lapaquistat Acetate Co-Administered With Statins in Subjects With Hypercholesterolemia Terminated Hypercholesterolemia NCT00532311
A Study of LY3015014 in Participants With High Cholesterol Completed Hypercholesterolemia NCT01890967
Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives Recruiting Stroke|Transient Ischemic Attack|Hypertension NCT01563731
A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients With Hypertriglyceridemia and on Statin. The Primary Objective is to Evaluate the Effect of 4 g/Day AMR101 for Preventing the Occurrence of a First Major Cardiovascular Event. Completed Cardiovascular Diseases NCT01492361
Efficacy and Safety of AMR101 (Ethyl Icosapentate) in Patients With Fasting Triglyceride (Tg) Levels ≥ 500 and ≤ 2000 mg/dL Completed Hypertriglyceridemia NCT01047683
Effect of AMR101 (Ethyl Icosapentate) on Triglyceride (Tg) Levels in Patients on Statins With High Tg Levels (≥ 200 and < 500 mg/dL) Completed Hypertriglyceridemia NCT01047501
Studies of Traditional Chinese Medicine Clinical Efficacy Evaluation Index Completed Coronary Heart Disease|Stable Angina Pectoris NCT01502943
Belatacept Evaluation of Nephroprotection and Efficacy as First-line Immunosuppression (BENEFIT) Completed Kidney Transplantation|Chronic Kidney Failure NCT00256750

Visualization

References

Publication DOI Pubmed PMCID
Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice. International journal of molecular sciences Xiaoxu Zhou, Dan Li, Wei Yan, Weimin Li, 9, 11, None, 2008-11-14, 10.3390/ijms9112253 10.3390/ijms9112253 19330073 PMC2635628

Filter data

Compound Pravastatin
Experiment types ELISA, Hematoxilin and eosin stainig , LDL level assesment , TC levels assesment, Western Blot
Concentrations 80.00
Cell lines serum, thoracoabdominal aortas, vessel
Organisms Mus musculus
Animal models ApoE-/-, C57BL/6J
STAT proteins STAT3, p-STAT3
Other IL-6, SOCS3, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Pravastatin Hematoxilin and eosin stainig Influence on atherosclerotic plaques development 80.00 mg/kg vessel Mus musculus ApoE-/-
Pravastatin LDL level assesment Influence on atherosclerosis progression 80.00 mg/kg serum Mus musculus ApoE-/-
Pravastatin TC levels assesment Influence on atherosclerosis progression 80.00 mg/kg serum Mus musculus ApoE-/-
Pravastatin Hematoxilin and eosin stainig Influence on atherosclerosis progression 80.00 mg/kg vessel Mus musculus C57BL/6J
Pravastatin LDL level assesment Influence on atherosclerosis progression 80.00 mg/kg serum Mus musculus C57BL/6J
Pravastatin TC levels assesment Influence on atherosclerosis progression 80.00 mg/kg serum Mus musculus C57BL/6J
Pravastatin ELISA Influence on atherosclerosis progression 80.00 mg/kg serum Mus musculus ApoE-/-
Pravastatin ELISA Influence on atherosclerosis progression 80.00 mg/kg serum Mus musculus C57BL/6J
Pravastatin Western Blot Influence on atherosclerosis progression 80.00 mg/kg thoracoabdominal aortas Mus musculus ApoE-/- p-STAT3
Pravastatin Western Blot Influence on atherosclerosis progression 80.00 mg/kg thoracoabdominal aortas Mus musculus C57BL/6J p-STAT3
Pravastatin Western Blot Influence on atherosclerosis progression 80.00 mg/kg thoracoabdominal aortas Mus musculus ApoE-/- STAT3
Pravastatin Western Blot Influence on atherosclerosis progression 80.00 mg/kg thoracoabdominal aortas Mus musculus C57BL/6J STAT3
Pravastatin Western Blot Influence on atherosclerosis progression 80.00 mg/kg thoracoabdominal aortas Mus musculus ApoE-/-
Pravastatin Western Blot Influence on atherosclerosis progression 80.00 mg/kg thoracoabdominal aortas Mus musculus C57BL/6J
Pravastatin Western Blot Influence on atherosclerosis progression 80.00 mg/kg thoracoabdominal aortas Mus musculus ApoE-/-
Pravastatin Western Blot Influence on atherosclerosis progression 80.00 mg/kg thoracoabdominal aortas Mus musculus C57BL/6J