PMM-172

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Short-term measurement of catabolic rates using iodine-labeled plasma protein. The Journal of clinical investigation A S McFarlane, A Koj, 49, 10, None, None, 10.1038/s41598-017-02671-7 10.1038/s41598-017-02671-7 5460289 PMC5460289

Filter data

Compound PMM-172
Experiment types Flow cytometry- annexin V binding and propidium iodide staining, JC-1 staining, Western Blot
Concentrations 2.00, 4.00, 8.00
Cell lines MDA-MB-231
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, STAT5, p-STAT1, p-STAT3 (Y705), p-STAT5
Other Bcl-2, Bcl-xL, Caspase-3, Cleaved Caspase-3, Cleaved-PARP, Cyclin D1, GAPDH, PARP, Survivin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
PMM-172 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on cell apoptosis 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 JC-1 staining Influence mitochondrial transmembrane 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 JC-1 staining Influence mitochondrial transmembrane 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 JC-1 staining Influence mitochondrial transmembrane 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on protien activity 2.00 µM MDA-MB-231 Homo sapiens STAT3
PMM-172 Western Blot Influence on protien activity 4.00 µM MDA-MB-231 Homo sapiens STAT3
PMM-172 Western Blot Influence on protien activity 8.00 µM MDA-MB-231 Homo sapiens STAT3
PMM-172 Western Blot Influence on protien activity 2.00 µM MDA-MB-231 Homo sapiens p-STAT3 (Y705)
PMM-172 Western Blot Influence on protien activity 4.00 µM MDA-MB-231 Homo sapiens p-STAT3 (Y705)
PMM-172 Western Blot Influence on protien activity 8.00 µM MDA-MB-231 Homo sapiens p-STAT3 (Y705)
PMM-172 Western Blot Influence on protien activity 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on protien activity 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on protien activity 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on protien activity in presence of IL-6 2.00 µM MDA-MB-231 Homo sapiens STAT3
PMM-172 Western Blot Influence on protien activity in presence of IL-6 2.00 µM MDA-MB-231 Homo sapiens p-STAT3 (Y705)
PMM-172 Western Blot Influence on protien activity in presence of IL-6 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on protien activity 2.00 µM MDA-MB-231 Homo sapiens STAT1
PMM-172 Western Blot Influence on protien activity 4.00 µM MDA-MB-231 Homo sapiens STAT1
PMM-172 Western Blot Influence on protien activity 8.00 µM MDA-MB-231 Homo sapiens STAT1
PMM-172 Western Blot Influence on protien activity 2.00 µM MDA-MB-231 Homo sapiens p-STAT1
PMM-172 Western Blot Influence on protien activity 4.00 µM MDA-MB-231 Homo sapiens p-STAT1
PMM-172 Western Blot Influence on protien activity 8.00 µM MDA-MB-231 Homo sapiens p-STAT1
PMM-172 Western Blot Influence on protien activity 2.00 µM MDA-MB-231 Homo sapiens STAT5
PMM-172 Western Blot Influence on protien activity 4.00 µM MDA-MB-231 Homo sapiens STAT5
PMM-172 Western Blot Influence on protien activity 8.00 µM MDA-MB-231 Homo sapiens STAT5
PMM-172 Western Blot Influence on protien activity 2.00 µM MDA-MB-231 Homo sapiens p-STAT5
PMM-172 Western Blot Influence on protien activity 4.00 µM MDA-MB-231 Homo sapiens p-STAT5
PMM-172 Western Blot Influence on protien activity 8.00 µM MDA-MB-231 Homo sapiens p-STAT5
PMM-172 Western Blot Influence on protien activity 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 8.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 2.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 4.00 µM MDA-MB-231 Homo sapiens
PMM-172 Western Blot Influence on STAT3 target protein activity 8.00 µM MDA-MB-231 Homo sapiens