PM-73G

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT; Peptidomimetic
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis. Journal of experimental therapeutics & oncology Edmond J Auzenne, Jim Klostergaard, Pijus K Mandal, Warren S Liao, Zhen Lu, Fengqin Gao, Robert C Bast, Fredika M Robertson, John S McMurray, 10, 2, None, None, N/A N/A 23350355 PMC4033579
The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain. JAK-STAT John S McMurray, Pijus K Mandal, Warren S Liao, Jim Klostergaard, Fredika M Robertson, 1, 4, 2012-10-01, None, 10.4161/jkst.22682 10.4161/jkst.22682 24058783 PMC3670284

Filter data

Compound PM-73G
Experiment types Immunohistochemistry, MTT, Tumor volume, Western Blot
Concentrations 0.01, 0.05, 0.10, 0.30, 0.50, 1.00, 1.60, 200.00, 25.00, 40.00, 5.00, 50.00, 8.00
Cell lines MDA-MB-468, MDA-MB-468(xenograft)
Organisms Homo sapiens, Mus musculus
Animal models nude mice
STAT proteins STAT1, STAT3, STAT5, p-STAT1, p-STAT3, p-STAT5
Other AKT, CD31, FAK, VEGF, p-AKT, p-FAK

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
PM-73G Immunohistochemistry Influence on protein astivity in tumor tissue 200.00 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Immunohistochemistry Influence on protein astivity in tumor tissue 40.00 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Immunohistochemistry Influence on protein astivity in tumor tissue 8.00 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Immunohistochemistry Influence on protein astivity in tumor tissue 1.60 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Immunohistochemistry Influence on protein astivity in tumor tissue 0.30 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Tumor volume Influence on protein astivity in tumor tissue 5.00 mM MDA-MB-468(xenograft) Mus musculus nude mice
PM-73G Immunohistochemistry Influence on microvessel density 5.00 mM MDA-MB-468(xenograft) Mus musculus nude mice p-STAT3
PM-73G Immunohistochemistry Influence on microvessel density 5.00 mM MDA-MB-468(xenograft) Mus musculus nude mice STAT3
PM-73G Immunohistochemistry Influence on microvessel density 5.00 mM MDA-MB-468(xenograft) Mus musculus nude mice
PM-73G Immunohistochemistry Influence on microvessel density 5.00 mM MDA-MB-468(xenograft) Mus musculus nude mice
PM-73G Western Blot Influence on protein activity 0.01 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Western Blot Influence on protein activity 0.05 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Western Blot Influence on protein activity 0.50 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens p-STAT3
PM-73G Western Blot Influence on protein activity 0.01 µM MDA-MB-468 Homo sapiens STAT3
PM-73G Western Blot Influence on protein activity 0.05 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 0.10 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 0.50 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity in presence of IFNγ 0.01 µM MDA-MB-468 Homo sapiens p-STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 0.05 µM MDA-MB-468 Homo sapiens p-STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 0.10 µM MDA-MB-468 Homo sapiens p-STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 0.50 µM MDA-MB-468 Homo sapiens p-STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 1.00 µM MDA-MB-468 Homo sapiens p-STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 5.00 µM MDA-MB-468 Homo sapiens p-STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 0.01 µM MDA-MB-468 Homo sapiens STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 0.05 µM MDA-MB-468 Homo sapiens STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 0.10 µM MDA-MB-468 Homo sapiens STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 0.50 µM MDA-MB-468 Homo sapiens STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 1.00 µM MDA-MB-468 Homo sapiens STAT1
PM-73G Western Blot Influence on protein activity in presence of IFNγ 5.00 µM MDA-MB-468 Homo sapiens STAT1
PM-73G Western Blot Influence on protein activity in presence of EGF 5.00 µM MDA-MB-468 Homo sapiens p-STAT5
PM-73G Western Blot Influence on protein activity in presence of EGF 5.00 µM MDA-MB-468 Homo sapiens STAT5
PM-73G Western Blot Influence on protein activity in presence of EGF 5.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity in presence of EGF 5.00 µM MDA-MB-468 Homo sapiens
PM-73G MTT Influence on cell viability 50.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 25.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 25.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 25.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 5.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 25.00 µM MDA-MB-468 Homo sapiens
PM-73G Western Blot Influence on protein activity 25.00 µM MDA-MB-468 Homo sapiens p-STAT5
PM-73G Western Blot Influence on protein activity 25.00 µM MDA-MB-468 Homo sapiens STAT5