PM-43I

Name Value
Weight 559.559 g/mol
Zinc ID N/A
Smiles N/A
Molecular formula C30H30N3O6P
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS 1637532-77-4

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease. The Journal of biological chemistry J Morgan Knight, Pijus Mandal, Pietro Morlacchi, Garbo Mak, Evan Li, Matthew Madison, Cameron Landers, Brandon Saxton, Ed Felix, Brian Gilbert, Joel Sederstrom, Atul Varadhachary, Melissa M Singh, Dev Chatterjee, David B Corry, John S McMurray, 293, 26, 2018-06-29, 2018-05-08, 10.1074/jbc.RA117.000567 10.1074/jbc.RA117.000567 29739850 PMC6028980

Vendors

Company Lnk to product
ProbeChem http://www.probechem.com/products_PM-43I.aspx
Glixx Laboratories http://glixxlabs.com/chemical-products/bioactive-screen-leads-p6/GLXC-12831

Filter data

Compound PM-43I
Experiment types Western Blot
Concentrations 0.05, 0.10, 0.50, 1.00, 2.50, 5.00
Cell lines BEAS-2B
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, STAT5, STAT6, p-STAT1 (Y701), p-STAT3 (Y705), p-STAT5 (Y694), p-STAT6
Other AKT, FAK, p-AKT (S473), p-FAK (Y861), β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
PM-43I Western Blot Influence on protein in presence IL-4 0.05 µM BEAS-2B Homo sapiens p-STAT6
PM-43I Western Blot Influence on protein in presence IL-4 0.10 µM BEAS-2B Homo sapiens p-STAT6
PM-43I Western Blot Influence on protein in presence IL-4 0.50 µM BEAS-2B Homo sapiens p-STAT6
PM-43I Western Blot Influence on protein in presence IL-4 1.00 µM BEAS-2B Homo sapiens p-STAT6
PM-43I Western Blot Influence on protein in presence IL-4 2.50 µM BEAS-2B Homo sapiens p-STAT6
PM-43I Western Blot Influence on protein in presence IL-4 5.00 µM BEAS-2B Homo sapiens p-STAT6
PM-43I Western Blot Influence on protein in presence IL-4 0.05 µM BEAS-2B Homo sapiens STAT6
PM-43I Western Blot Influence on protein in presence IL-4 0.10 µM BEAS-2B Homo sapiens STAT6
PM-43I Western Blot Influence on protein in presence IL-4 0.50 µM BEAS-2B Homo sapiens STAT6
PM-43I Western Blot Influence on protein in presence IL-4 1.00 µM BEAS-2B Homo sapiens STAT6
PM-43I Western Blot Influence on protein in presence IL-4 2.50 µM BEAS-2B Homo sapiens STAT6
PM-43I Western Blot Influence on protein in presence IL-4 5.00 µM BEAS-2B Homo sapiens STAT6
PM-43I Western Blot Influence on protein in presence IL-4 0.05 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence IL-4 0.10 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence IL-4 0.50 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence IL-4 1.00 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence IL-4 2.50 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence IL-4 5.00 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 0.50 µM BEAS-2B Homo sapiens p-STAT5 (Y694)
PM-43I Western Blot Influence on protein in presence EGF 1.00 µM BEAS-2B Homo sapiens p-STAT5 (Y694)
PM-43I Western Blot Influence on protein in presence EGF 0.50 µM BEAS-2B Homo sapiens STAT5
PM-43I Western Blot Influence on protein in presence EGF 1.00 µM BEAS-2B Homo sapiens STAT5
PM-43I Western Blot Influence on protein in presence EGF 0.50 µM BEAS-2B Homo sapiens p-STAT3 (Y705)
PM-43I Western Blot Influence on protein in presence EGF 1.00 µM BEAS-2B Homo sapiens p-STAT3 (Y705)
PM-43I Western Blot Influence on protein in presence EGF 0.50 µM BEAS-2B Homo sapiens STAT3
PM-43I Western Blot Influence on protein in presence EGF 1.00 µM BEAS-2B Homo sapiens STAT3
PM-43I Western Blot Influence on protein in presence EGF 0.50 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 1.00 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 0.50 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 1.00 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 0.50 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 1.00 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 0.50 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 1.00 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 0.50 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence EGF 1.00 µM BEAS-2B Homo sapiens
PM-43I Western Blot Influence on protein in presence IFNγ 0.50 µM BEAS-2B Homo sapiens p-STAT1 (Y701)
PM-43I Western Blot Influence on protein in presence IFNγ 1.00 µM BEAS-2B Homo sapiens p-STAT1 (Y701)
PM-43I Western Blot Influence on protein in presence IFNγ 0.50 µM BEAS-2B Homo sapiens STAT1
PM-43I Western Blot Influence on protein in presence IFNγ 1.00 µM BEAS-2B Homo sapiens STAT1