Peficitinib (ASP015K, JNJ-54781532)

Name Value
Weight 326.400 g/mol
Zinc ID ZINC103297953
Smiles NC(=O)c1cnc2[nH]ccc2c1N[C@H]1[C@H]2CC3C[C@@H]1C[C@](O)(C3)C2
Molecular formula C18H22N4O2
Mode of inhibition N/A
CAS 944118-01-8

Clinical Trials

Study title Status Conditions Link
Japan Post-Marketing Surveillance for Peficitinib to Assess Safety and Effectiveness in the Patients With Rheumatoid Arthritis Recruiting Rheumatoid Arthritis (RA) NCT03971253
A Study to Evaluate the Pharmacokinetics and Safety of ASP015K in Healthy Chinese Subjects Completed Healthy Volunteers NCT04143477
Bioequivalence Evaluation of a New and Current Tablet of ASP015K Completed Healthy Volunteers NCT02531191
A Study to Evaluate the Effect of Verapamil on the Pharmacokinetics of ASP015K in Healthy Adult Subjects Completed Healthy Subjects|Pharmacokinetics of ASP015K NCT02111317
A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Metformin Completed Healthy Subjects NCT02760342
A Study to Assess the Relative Bioavailability Between Two ASP015K Tablets and the Food Effect of a New Tablet in Healthy Adult Subjects Completed Bioavailability of ASP015K|Healthy Subjects|Pharmacokinetics of ASP015K|Food Effect of ASP015K NCT01929577
A Study to Evaluate the Long-term Safety and Efficacy of ASP015K in Subjects Previously Enrolled in a Phase 2 ASP015K Rheumatoid Arthritis Study Completed Arthritis, Rheumatoid NCT01711814
A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid Arthritis Completed Rheumatoid Arthritis NCT01754805
Single and Multiple Oral Administration Study of ASP015K in Healthy Nonelderly Volunteers Completed Pharmacokinetics of ASP015K|Healthy Volunteer NCT01225224
A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis Completed Arthritis, Rheumatoid NCT01565655
A Study to Assess Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response or Intolerance to Methotrexate (MTX) Completed Rheumatoid Arthritis (RA) NCT03660059
A Study to Evaluate Efficacy and Safety of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to Methotrexate (MTX) Treatment Completed Rheumatoid Arthritis NCT02305849
A Study to Continue ASP015K Treatment to Rheumatoid Arthritis Patients Who Completed Phase IIb Study or Phase III Study of ASP015K Completed Arthritis, Rheumatoid NCT01638013
A Study to Evaluate Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to DMARDs Completed Rheumatoid Arthritis NCT02308163
A Single Oral Dose Study of ASP015K in Healthy Volunteers Assessing the Relative Bioavailability Across Three Tablet Strengths From a New Formulation of ASP015K Completed Bioavailability of ASP015K|Pharmacokinetics of ASP015K|Healthy Subjects NCT01486017
A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis Subjects Who Have Had an Inadequate Response to Methotrexate Completed Arthritis, Rheumatoid NCT01554696
A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP015K in Healthy Subjects Completed Healthy Volunteers|Pharmacokinetics of ASP015K NCT02141425
A Study to Evaluate the Efficacy and Safety of ASP015K in Moderate to Severe Rheumatoid Arthritis Subjects Completed Arthritis, Rheumatoid NCT01649999
A Study to Assess the Pharmacokinetics of ASP015K in Healthy Male Subjects Completed Healthy Subjects|Pharmacokinetics of ASP015K NCT01406132
Drug-Drug Interaction Study Evaluating Effects of ASP015K on Rosuvastatin Completed Healthy Subjects|Pharmacokinetics of ASP015K NCT01959399
A Phase I Study to Compare 3 Different Strengths of an Extended Release Formulation of ASP015K to an Immediate Release Formulation of ASP015K Completed Pharmacokinetics of ASP015K|Food Effect|Healthy Volunteers NCT01686217
A Study to Explore Efficacy and Safety of ASP015K in Subjects With Moderate to Severe Psoriasis Completed Psoriasis NCT01096862
A Single Oral Dose Study to Compare the Bioavailability Between Two Different Tablet Formulations and Assess if There is a Food Effect With the New Formulation Completed Pharmacokinetics of ASP015K|Bioavailability of ASP015K|Healthy Subjects NCT01484964
A Study to Assess Drug Interaction of ASP015K and Midazolam Completed Healthy|Pharmacokinetics of ASP015K and Midazolam NCT01182077
Pharmacokinetic Interaction Study to Assess the Effect of ASP015K on Mycophenolate Mofetil in Healthy Volunteers Completed Healthy Subjects|Drug Interactions|Pharmacokinetics of ASP015K NCT01364987
A Study to Evaluate the Drug Interaction of ASP015K and Tacrolimus Completed Healthy|Pharmacokinetics of ASP015K and Tacrolimus NCT01190670
Pharmacokinetic Interaction Study to Assess the Effect of ASP015K on Tacrolimus in Healthy Volunteers Completed Pharmacokinetics of ASP015K|Drug Interactions|Healthy Subjects NCT01430065
A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP015K Completed Healthy Subjects|Pharmacokinetics of ASP015K|Pharmacodynamics NCT01364974
A Study to Assess the Bioavailability of ASP015K Completed Healthy NCT01430078
A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP015K Completed Healthy Subjects|Pharmacokinetics of ASP015K NCT01387087
Pharmacokinetics Study in Patients With Impaired Renal Function and Subjects With Normal Renal Function Completed Patients With Impaired Renal Function NCT02603497
Pharmacokinetics Study in Patients With Impaired Hepatic Function Completed Patients With Impaired Hepatic Function NCT02586194
A Study of Safety and Effectiveness of JNJ-54781532 in Patients With Moderately to Severely Active Ulcerative Colitis Completed Colitis, Ulcerative NCT01959282
A Study to Evaluate Absorption, Distribution and Elimination of Mirabegron After Oral Administration to Non-elderly Healthy Chinese Subjects Completed Healthy Subjects|Plasma Concentration of Mirabegron NCT01747564

References

Publication DOI Pubmed PMCID

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Compound Peficitinib (ASP015K, JNJ-54781532)
Experiment types
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Cell lines
Organisms
Animal models
STAT proteins
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Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details