Oleanolic Acid

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition JAK2, STAT, SRC, EGFR; Natural product
CAS 508-02-1

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. Oncology reports Yukio Fujiwara, Yoshihiro Komohara, Rino Kudo, Keiichiro Tsurushima, Koji Ohnishi, Tsuyoshi Ikeda, Motohiro Takeya, 26, 6, None, 2011-09-12, 10.3892/or.2011.1454 10.3892/or.2011.1454 21922144 21922144
Oleanolic acid suppresses resistin induction in adipocytes by modulating Tyk-STAT signaling. Nutrition research (New York, N.Y.) Hyun-Sung Kim, Hye-Young Sung, Min Soo Kim, Jung-Lye Kim, Min-Kyung Kang, Ju-Hyun Gong, Hyoung-Sook Park, Young-Hee Kang, 33, 2, None, 2013-01-26, 10.1016/j.nutres.2012.12.006 10.1016/j.nutres.2012.12.006 23399665 23399665

Vendors

Company Lnk to product
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/aldrich/o5504?lang=pl&region=PL
Caymanchemical https://www.caymanchem.com/product/11726/
Tocris https://www.tocris.com/products/oleanolic-acid_6026
Selleckchem https://www.selleckchem.com/products/Oleanolic-Acid(Caryophyllin).html
Adooq Bioscience https://www.adooq.com/oleanolic-acid-caryophyllin.html

Filter data

Compound Oleanolic Acid
Experiment types ELISA, Immunocytochemical staining, RT-PCR, WST-8, Western Blot
Concentrations 1.00, 10.00, 100.00, 150.00, 25.00, 30.00, 5.00, 50.00
Cell lines 3T3-L1, HMDM
Organisms Homo sapiens
Animal models
STAT proteins p-STAT1, p-STAT3
Other GAPDH, IL-12, Resistin, Resistin (lysates), Resistin (media), SOCS3, p-Tyk2, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Oleanolic Acid ELISA Influence on cell viability 30.00 µM HMDM Homo sapiens
Oleanolic Acid WST-8 Influence on cell viability 10.00 µM HMDM Homo sapiens
Oleanolic Acid WST-8 Influence on cell viability 30.00 µM HMDM Homo sapiens
Oleanolic Acid WST-8 Influence on cell viability 50.00 µM HMDM Homo sapiens
Oleanolic Acid WST-8 Influence on cell viability 100.00 µM HMDM Homo sapiens
Oleanolic Acid WST-8 Influence on cell viability 150.00 µM HMDM Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 1.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 5.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 10.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 25.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 1.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 5.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 10.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 25.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 1.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 5.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 10.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 25.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid RT-PCR Influence on gene expresion 1.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid RT-PCR Influence on gene expresion 5.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid RT-PCR Influence on gene expresion 10.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid RT-PCR Influence on gene expresion 25.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid RT-PCR Influence on gene expresion 1.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid RT-PCR Influence on gene expresion 5.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid RT-PCR Influence on gene expresion 10.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid RT-PCR Influence on gene expresion 25.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 1.00 µM 3T3-L1 Homo sapiens p-STAT1
Oleanolic Acid Western Blot Influence on protein activity 5.00 µM 3T3-L1 Homo sapiens p-STAT1
Oleanolic Acid Western Blot Influence on protein activity 10.00 µM 3T3-L1 Homo sapiens p-STAT1
Oleanolic Acid Western Blot Influence on protein activity 25.00 µM 3T3-L1 Homo sapiens p-STAT1
Oleanolic Acid Western Blot Influence on protein activity 1.00 µM 3T3-L1 Homo sapiens p-STAT3
Oleanolic Acid Western Blot Influence on protein activity 5.00 µM 3T3-L1 Homo sapiens p-STAT3
Oleanolic Acid Western Blot Influence on protein activity 10.00 µM 3T3-L1 Homo sapiens p-STAT3
Oleanolic Acid Western Blot Influence on protein activity 25.00 µM 3T3-L1 Homo sapiens p-STAT3
Oleanolic Acid Immunocytochemical staining Influence on protein activity 1.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Immunocytochemical staining Influence on protein activity 5.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Immunocytochemical staining Influence on protein activity 10.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Immunocytochemical staining Influence on protein activity 25.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 1.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 5.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 10.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 25.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 1.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 5.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 10.00 µM 3T3-L1 Homo sapiens
Oleanolic Acid Western Blot Influence on protein activity 25.00 µM 3T3-L1 Homo sapiens