Oleandrin

Name Value
Weight 576.700 g/mol
Zinc ID N/A
Smiles CC1C(C(CC(O1)OC2CCC3(C(C2)CCC4C3CCC5(C4(CC(C5C6=CC(=O)OC6)OC(=O)C)O)C)C)OC)O
Molecular formula C32H48O9
Mode of inhibition Nf-κB, OCT3/4, STAT, MMP inhibitor; Natural product
CAS 465-16-7

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Comparison of the renal excretory mechanisms of cefmenoxime and other cephalosporins: renal clearance in rats and rabbits. The Journal of antibiotics I Yamazaki, Y Shirakawa, T Fugono, 34, 8, None, None, 10.3390/ijms19113350 10.3390/ijms19113350 6274837 PMC6274837

Vendors

Company Lnk to product
Adooq https://www.adooq.com/oleandrin.html
MedChemExpress http://medchemexpress.net/Oleandrin.html

Filter data

Compound Oleandrin
Experiment types Cell invasion assay, Clonogenic assay , Colony formation assay , MTT Assay , RT-PCR, Western Blot
Concentrations 1.00, 10.00, 100.00, 30.00, 50.00, 500.00
Cell lines EC, MDA-MB-231, RT-R-MDA-MB-231
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3
Other MMP-9, OCT3/4, β-actin, β-catenin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Oleandrin MTT Assay Infuence on cell viability 1.00 nM MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 10.00 nM MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 30.00 nM MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 50.00 nM MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 100.00 nM MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 500.00 nM MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 1.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 10.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 30.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 50.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 100.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 500.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 1.00 nM EC Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 10.00 nM EC Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 30.00 nM EC Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 50.00 nM EC Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 100.00 nM EC Homo sapiens
Oleandrin MTT Assay Infuence on cell viability 500.00 nM EC Homo sapiens
Oleandrin Colony formation assay Influence on cell motility 1.00 nM MDA-MB-231 Homo sapiens
Oleandrin Colony formation assay Influence on cell motility 10.00 nM MDA-MB-231 Homo sapiens
Oleandrin Colony formation assay Influence on cell motility 30.00 nM MDA-MB-231 Homo sapiens
Oleandrin Colony formation assay Influence on cell motility 100.00 nM MDA-MB-231 Homo sapiens
Oleandrin Colony formation assay Influence on cell motility 1.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Colony formation assay Influence on cell motility 10.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Colony formation assay Influence on cell motility 30.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Colony formation assay Influence on cell motility 100.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Clonogenic assay Influence on cell motility 1.00 nM MDA-MB-231 Homo sapiens
Oleandrin Clonogenic assay Influence on cell motility 10.00 nM MDA-MB-231 Homo sapiens
Oleandrin Clonogenic assay Influence on cell motility 30.00 nM MDA-MB-231 Homo sapiens
Oleandrin Clonogenic assay Influence on cell motility 100.00 nM MDA-MB-231 Homo sapiens
Oleandrin Clonogenic assay Influence on cell motility 1.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Clonogenic assay Influence on cell motility 10.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Clonogenic assay Influence on cell motility 30.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Clonogenic assay Influence on cell motility 100.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Cell invasion assay Influence on cell motility 1.00 nM MDA-MB-231 Homo sapiens
Oleandrin Cell invasion assay Influence on cell motility 10.00 nM MDA-MB-231 Homo sapiens
Oleandrin Cell invasion assay Influence on cell motility 30.00 nM MDA-MB-231 Homo sapiens
Oleandrin Cell invasion assay Influence on cell motility 50.00 nM MDA-MB-231 Homo sapiens
Oleandrin Cell invasion assay Influence on cell motility 1.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Cell invasion assay Influence on cell motility 10.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Cell invasion assay Influence on cell motility 30.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Cell invasion assay Influence on cell motility 50.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Western Blot Influence on protein activity 100.00 nM MDA-MB-231 Homo sapiens
Oleandrin Western Blot Influence on protein activity 100.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Western Blot Influence on protein activity 100.00 nM MDA-MB-231 Homo sapiens
Oleandrin Western Blot Influence on protein activity 100.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Western Blot Influence on protein activity 100.00 nM MDA-MB-231 Homo sapiens
Oleandrin Western Blot Influence on protein activity 100.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin RT-PCR Influence on mRNA expression 100.00 nM MDA-MB-231 Homo sapiens
Oleandrin RT-PCR Influence on mRNA expression 100.00 nM RT-R-MDA-MB-231 Homo sapiens
Oleandrin Western Blot Influence on protein activity 100.00 nM MDA-MB-231 Homo sapiens p-STAT3
Oleandrin Western Blot Influence on protein activity 100.00 nM RT-R-MDA-MB-231 Homo sapiens p-STAT3
Oleandrin Western Blot Influence on protein activity 100.00 nM MDA-MB-231 Homo sapiens STAT3
Oleandrin Western Blot Influence on protein activity 100.00 nM RT-R-MDA-MB-231 Homo sapiens STAT3