| A Study to Evaluate the Mass Balance of 14C-Napabucasin in Healthy Adult Male Subjects |
Completed |
ADME|Healthy |
NCT03525405 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Drug Interaction Potential of Napabucasin in Healthy Volunteers |
Completed |
Drug-drug Interactions |
NCT03411122 |
| A Study of Napabucasin (BBI-608) Plus Weekly Paclitaxel Versus Weekly Paclitaxel Alone in Patients With Advanced, Previously Treated, Non-Squamous Non-Small Cell Lung Cancer |
Terminated |
Carcinoma, Non-Small-Cell Lung |
NCT02826161 |
| A Study of BBI608 Administered With Paclitaxel in Adult Patients With Advanced Malignancies |
Completed |
Cancer |
NCT01325441 |
| A Study of Napabucasin Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With Metastatic Pancreatic Adenocarcinoma |
Completed |
Carcinoma, Pancreatic Ductal |
NCT02993731 |
| A Phase III Clinical Study of Napabucasin (GB201) Plus FOLFIRI in Adult Patients With Metastatic Colorectal Cancer |
Unknown status |
Previously Treated Metastatic Colorectal Cancer |
NCT03522649 |
| A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer |
Completed |
Colorectal Cancer |
NCT02753127 |
| A Study of Napabucasin in Combination With Weekly Paclitaxel and Low-dose Gemcitabine in Patients With Pancreatic Cancer |
Unknown status |
Metastatic Pancreatic Cancer |
NCT03721744 |
| A Study of BBI608 in Combination With Sorafenib, or BBI503 in Combination With Sorafenib in Adult Patients With Hepatocellular Carcinoma |
Completed |
Hepatocellular Carcinoma |
NCT02279719 |
| A Study of BBI608 in Combination With Temozolomide in Adult Patients With Recurrent or Progressed Glioblastoma |
Completed |
Glioblastoma |
NCT02315534 |
| A Study of BBI608 in Adult Patients With Advanced Colorectal Cancer |
Completed |
Colorectal Cancer |
NCT01776307 |
| A Study of BBI608 Plus Weekly Paclitaxel to Treat Gastric and Gastro-Esophageal Junction Cancer |
Completed |
Gastric Cancer|Gastroesophageal Junction Cancer |
NCT02178956 |
| A Study of BBI608 and BBI503 Administered in Combination to Adult Patients With Advanced Solid Tumors |
Completed |
Cancer|Advanced Solid Tumors |
NCT02432326 |
| A Study of BBI608 in Adult Patients With Advanced, Refractory Hematologic Malignancies |
Completed |
Hematologic Malignancy |
NCT02352558 |
| Rollover Study to Provide Continued Access to Napabucasin for Patients Enrolled in Boston Biomedical-sponsored Protocols |
Completed |
Oncology |
NCT04299880 |
| Special Combination of BBI608 and Pembrolizumab |
Terminated |
Metastatic Colorectal Cancer |
NCT02851004 |
| A Study of BBI608 in Adult Patients With Advanced Malignancies |
Completed |
Cancer, Advanced Malignancies |
NCT01775423 |
| A Study of BBI608 Administered in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Cancers |
Completed |
Cancer |
NCT02467361 |
| A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer |
Completed |
Advanced Gastrointestinal Cancer |
NCT02024607 |
| A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Pancreatic Cancer |
Completed |
Metastatic Pancreatic Adenocarcinoma |
NCT02231723 |
| A Study of BBI608 Administrated With Sorafenib in Adult Patients With Advanced Hepatocellular Carcinoma |
Completed |
Hepatocellular Carcinoma |
NCT02358395 |
| A Study of BBI608 in Combination With Pemetrexed and Cisplatin in Adult Patients With Malignant Pleural Mesothelioma |
Completed |
Malignant Pleural Mesothelioma|Non-Small Cell Lung Cancer |
NCT02347917 |
| BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinoma |
Completed |
Colorectal Carcinoma |
NCT01830621 |
| A Study of BBI608 Administrated With FOLFIRI + Bevacizumab in Adult Patients With Metastatic Colorectal Cancer |
Completed |
Metastatic Colorectal Cancer |
NCT02641873 |
| Modulation Of The Tumour Microenvironment Using Either Vascular Disrupting Agents or STAT3 Inhibition in Order to Synergise With PD1 Inhibition in Microsatellite Stable, Refractory Colorectal Cancer |
Completed |
Colorectal Cancer Metastatic |
NCT03647839 |
| A Study of DSP-0337 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic Profile |
Terminated |
Neoplasms |
NCT03416816 |
| A Study of BBI503 in Adult Patients With Advanced Urologic Malignancies |
Withdrawn |
Urologic Malignancies|Renal Cell Carcinoma|Urothelial Carcinoma |
NCT02232646 |
