Methylseleninic Acid

Name Value
Weight 127.010 g/mol
Zinc ID N/A
Smiles C[Se](=O)O
Molecular formula CH4O2Se
Mode of inhibition JAK and STAT inhibitor; Non-peptide small molecule
CAS 28274-57-9

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Methylseleninic Acid Suppresses Breast Cancer Growth via the JAK2/STAT3 Pathway. Reproductive sciences (Thousand Oaks, Calif.) Changwei Qiu, Tao Zhang, Xinying Zhu, Jinxia Qiu, Kangfeng Jiang, Gan Zhao, Haichong Wu, Ganzhen Deng, 26, 6, None, 2018-12-09, 10.1177/1933719118815582 10.1177/1933719118815582 30526368 30526368

Vendors

Company Lnk to product
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/aldrich/541281?lang=pl&region=PL

Filter data

Compound Methylseleninic Acid
Experiment types Flow cytometry- annexin V binding and propidium iodide staining, RT-PCR, RT-qPCR, TUNEL, Tumor volume, Tumor weight, Western Blot
Concentrations 1.50, 10.00, 20.00, 5.00
Cell lines 4TI, 4TI (xenograft)
Organisms Mus musculus
Animal models BALB/c
STAT proteins STAT1, STAT2, STAT3, STAT5A, STAT5B, STAT6, p-STAT3
Other Bax, Bcl-2, Caspase-3, Cleaved PARP, Cleaved caspase-3, JAK1, JAK2, JAK3, MMP-2, MMP-9, PARP, TIMP1, TIMP2, XIAP, cXIAP, p-JAK2, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Methylseleninic Acid Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 5.00 µM 4TI Mus musculus
Methylseleninic Acid Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 10.00 µM 4TI Mus musculus
Methylseleninic Acid Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell apoptosis 20.00 µM 4TI Mus musculus
Methylseleninic Acid RT-qPCR Influence on cell apoptosis 5.00 µM 4TI Mus musculus
Methylseleninic Acid RT-qPCR Influence on cell apoptosis 10.00 µM 4TI Mus musculus
Methylseleninic Acid RT-qPCR Influence on cell apoptosis 20.00 µM 4TI Mus musculus
Methylseleninic Acid RT-qPCR Influence on cell apoptosis 5.00 µM 4TI Mus musculus
Methylseleninic Acid RT-qPCR Influence on cell apoptosis 10.00 µM 4TI Mus musculus
Methylseleninic Acid RT-qPCR Influence on cell apoptosis 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 20.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 5.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on cell motility 20.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 5.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 10.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 20.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 5.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 10.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 20.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 5.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 10.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 20.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 5.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 10.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on cell motility 20.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on mRNA expression 10.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on mRNA expression 10.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on mRNA expression 10.00 µM 4TI Mus musculus
Methylseleninic Acid RT-PCR Influence on mRNA expression 10.00 µM 4TI Mus musculus STAT1
Methylseleninic Acid RT-PCR Influence on mRNA expression 10.00 µM 4TI Mus musculus STAT2
Methylseleninic Acid RT-PCR Influence on mRNA expression 10.00 µM 4TI Mus musculus STAT3
Methylseleninic Acid RT-PCR Influence on mRNA expression 10.00 µM 4TI Mus musculus STAT5A
Methylseleninic Acid RT-PCR Influence on mRNA expression 10.00 µM 4TI Mus musculus STAT5B
Methylseleninic Acid RT-PCR Influence on mRNA expression 10.00 µM 4TI Mus musculus STAT6
Methylseleninic Acid Western Blot Influence on protein activity in presence of AG490 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on protein activity in presence of AG490 10.00 µM 4TI Mus musculus
Methylseleninic Acid Western Blot Influence on protein activity in presence of AG490 10.00 µM 4TI Mus musculus p-STAT3
Methylseleninic Acid Western Blot Influence on protein activity in presence of AG490 10.00 µM 4TI Mus musculus STAT3
Methylseleninic Acid Western Blot Influence on protein activity in presence of AG490 10.00 µM 4TI Mus musculus
Methylseleninic Acid Tumor weight Influence on cell proliferation in tumor tissue 1.50 mg/kg 4TI (xenograft) Mus musculus BALB/c
Methylseleninic Acid Tumor volume Influence on cell proliferation in tumor tissue 1.50 mg/kg 4TI (xenograft) Mus musculus BALB/c
Methylseleninic Acid TUNEL Influence on cell apoptosis in tumor tissue 1.50 mg/kg 4TI (xenograft) Mus musculus BALB/c
Methylseleninic Acid Western Blot Influence on protien activity in tumor tissue 1.50 mg/kg 4TI (xenograft) Mus musculus BALB/c
Methylseleninic Acid Western Blot Influence on protien activity in tumor tissue 1.50 mg/kg 4TI (xenograft) Mus musculus BALB/c
Methylseleninic Acid Western Blot Influence on protien activity in tumor tissue 1.50 mg/kg 4TI (xenograft) Mus musculus BALB/c
Methylseleninic Acid Western Blot Influence on protien activity in tumor tissue 1.50 mg/kg 4TI (xenograft) Mus musculus BALB/c
Methylseleninic Acid Western Blot Influence on protien activity in tumor tissue 1.50 mg/kg 4TI (xenograft) Mus musculus BALB/c