KYZ3

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT SH2;Cryptotanshinone derivative
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy 10.1038/s41419-018-1139-z N/A N/A

Filter data

Compound KYZ3
Experiment types Body weight, Flow Cytometry Annexin, Flow cytometry , Immunofluorescence staining , Immunohistochemistry, Immunohistochemistry HE, Immunohistochemistry Ki67, MTT, Trans-well cell migration , Tumor volume, Western Blot, Wound healing assay, qPCR
Concentrations 0.25, 0.50, 1.00, 15.00, 2.00, 30.00, 4.00
Cell lines MCF-10A, MDA-MB-231, MDA-MB-231(xenograft), MDA-MB-468
Organisms Homo sapiens, Mus musculus
Animal models BALB/c nude mice
STAT proteins STAT3, p-STAT3
Other Bax, Bcl-2, Caspase 3, Cleaved Caspase 3 , Cleaved PARP, Cyclin D1, GAPDH, MMP-9, PARP, p-Erk, p-Src

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
KYZ3 MTT Influence on cell viability 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 MTT Influence on cell viability 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-468 Homo sapiens p-STAT3
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens p-STAT3
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens p-STAT3
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-231 Homo sapiens p-STAT3
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens p-STAT3
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens p-STAT3
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-468 Homo sapiens STAT3
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens STAT3
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens STAT3
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-231 Homo sapiens STAT3
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens STAT3
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens STAT3
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 qPCR Influence on gene expression 0.50 µM MDA-MB-468 Homo sapiens
KYZ3 qPCR Influence on gene expression 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 qPCR Influence on gene expression 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 qPCR Influence on gene expression 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 qPCR Influence on gene expression 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 qPCR Influence on gene expression 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 qPCR Influence on gene expression 0.50 µM MDA-MB-468 Homo sapiens
KYZ3 qPCR Influence on gene expression 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 qPCR Influence on gene expression 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 qPCR Influence on gene expression 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 qPCR Influence on gene expression 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 qPCR Influence on gene expression 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Immunofluorescence staining Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens p-STAT3
KYZ3 Immunofluorescence staining Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens p-STAT3
KYZ3 Wound healing assay Influence on cell migration 0.25 µM MDA-MB-231 Homo sapiens
KYZ3 Wound healing assay Influence on cell migration 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 Trans-well cell migration Influence on cell migration 0.25 µM MDA-MB-231 Homo sapiens
KYZ3 Trans-well cell migration Influence on cell migration 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 qPCR Influence on gene expression 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 qPCR Influence on gene expression 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 qPCR Influence on gene expression 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity in STAT3 transfected cells 2.00 µM MDA-MB-231 Homo sapiens p-STAT3
KYZ3 Western Blot Influence on protein activity in STAT3 transfected cells 2.00 µM MDA-MB-231 Homo sapiens STAT3
KYZ3 Western Blot Influence on protein activity in STAT3 transfected cells 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity in STAT3 transfected cells 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity in STAT3 transfected cells 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity in STAT3 transfected cells 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Flow cytometry Influence on ROS generation 0.50 µM MDA-MB-468 Homo sapiens
KYZ3 Flow cytometry Influence on ROS generation 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Flow cytometry Influence on ROS generation 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Flow cytometry Influence on ROS generation 0.50 µM MDA-MB-231 Homo sapiens
KYZ3 Flow cytometry Influence on ROS generation 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Flow cytometry Influence on ROS generation 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Flow Cytometry Annexin Influence on cell apoptosis 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Flow Cytometry Annexin Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Flow Cytometry Annexin Influence on cell apoptosis 4.00 µM MDA-MB-231 Homo sapiens
KYZ3 Flow Cytometry Annexin Influence on cell apoptosis 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Flow Cytometry Annexin Influence on cell apoptosis 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Flow Cytometry Annexin Influence on cell apoptosis 4.00 µM MDA-MB-468 Homo sapiens
KYZ3 Flow Cytometry Annexin Influence on cell apoptosis 1.00 µM MCF-10A Homo sapiens
KYZ3 Flow Cytometry Annexin Influence on cell apoptosis 2.00 µM MCF-10A Homo sapiens
KYZ3 Flow Cytometry Annexin Influence on cell apoptosis 4.00 µM MCF-10A Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-231 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 1.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 2.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-468 Homo sapiens
KYZ3 Western Blot Influence on protein activity 4.00 µM MDA-MB-468 Homo sapiens
KYZ3 Tumor volume Influence on tumor growth 15.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice
KYZ3 Tumor volume Influence on tumor growth 30.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice
KYZ3 Body weight Influence on tumor growth 15.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice
KYZ3 Body weight Influence on tumor growth 30.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice
KYZ3 Immunohistochemistry Ki67 Influence on tumor growth 15.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice
KYZ3 Immunohistochemistry Ki67 Influence on tumor growth 30.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice
KYZ3 Immunohistochemistry HE Influence on tumor growth 15.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice
KYZ3 Immunohistochemistry HE Influence on tumor growth 30.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice
KYZ3 Immunohistochemistry Influence on protein levels in tumor 15.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice p-STAT3
KYZ3 Immunohistochemistry Influence on protein levels in tumor 30.00 mg/kg MDA-MB-231(xenograft) Mus musculus BALB/c nude mice p-STAT3