Homoharringtonine

Name Value
Weight 545.629 g/mol
Zinc ID ZINC43450324
Smiles COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@@H]1C(OC)=C[C@]23CCCN2CCc2cc4c(cc2[C@@H]13)OCO4
Molecular formula C29H39NO9
Mode of inhibition N/A
CAS 26833-87-4

Clinical Trials

Study title Status Conditions Link
Combination of Quizartinib and Omacetaxine Mepesuccinate for AML Carrying FLT3-ITD Active, not recruiting AML|FLT3-ITD Mutation NCT03135054
Azacitidine and Homoharringtonine in JMML Recruiting JMML NCT04505995
Homoharringtonine With Oral Gleevec in Chronic, Accelerated and Blast Phase Chronic Myeloid Leukemia (CML) Terminated Myeloid Leukemia, Chronic|Myeloid Leukemia, Chronic, Accelerated-Phase|Blast Phase|Myeloid Leukemia, Chronic, Chronic-Phase NCT00114959
Homoharringtonine in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia Completed Childhood Chronic Myelogenous Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia|Relapsing Chronic Myelogenous Leukemia NCT00006364
Combination of Sorafenib and Omacetaxine Mepesuccinate in Newly Diagnosed or Relapsed/Refractory AML Carrying FLT3-ITD Completed AML|FLT3-ITD Mutation NCT03170895
Pharmacokinetic (PK) Study of Homoharringtonine (Omacetaxine Mepesuccinate) Administered Subcutaneously to Patients With Advanced Solid and Hematologic Tumors Completed Hematologic Tumors NCT00675350
Open Label Study of Subcutaneous Homoharringtonine (Omacetaxine Mepesuccinate) in Patients With Advanced CML Completed Chronic Myeloid Leukemia NCT00462943
Homoharringtonine Plus Low-Dose Cytarabine in Treating Patients With Newly Diagnosed Chronic Myelogenous Leukemia in Chronic Phase Completed Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia NCT00003694
Homoharringtonine Compared With Hydroxyurea for Chronic Myelogenous Leukemia That Has Not Responded to Interferon Alfa Terminated Leukemia NCT00004933
Homoharringtonine (Omacetaxine Mepesuccinate) in Treating Patients With Chronic Myeloid Leukemia (CML) With the T315I BCR-ABL Gene Mutation Completed Chronic Myeloid Leukemia NCT00375219
Homoharringtonine and Interferon Alfa in Treating Patients With Chronic Myelogenous Leukemia Completed Leukemia NCT00002574
Homoharringtonine in Treating Patients With Refractory Acute Promyelocytic Leukemia Withdrawn Leukemia NCT00030355
Chemotherapy and Biological Therapy in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia Completed Leukemia NCT00003239
An Open-Label Study to Investigate the Pharmacokinetics of Omacetaxine Mepesuccinate Completed Hematologic Malignancies|Solid Tumors NCT01844869
A Study to Evaluate the Pharmacokinetics, Safety,and Efficacy of Omacetaxine Given Subcutaneously as a Fixed Dose in Patients With Chronic Phase (CP) or Accelerated Phase (AP) Chronic Myeloid Leukemia (CML) (Referred to as the SYNSINCT Study) Terminated Chronic Myeloid Leukemia NCT02078960
Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Terminated Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia NCT02029417
PD-1 Inhibitor Combined With Azacytidine and Homoharringtonine，Cytarabine, G-CSF for Refractory or Relapsed AML Recruiting Immunotherapy|Refractory Leukemia|Relapsed Adult AML|Acute Myeloid Leukemia NCT04722952
DCHA as Postremission Therapy for AML With t(8;21) Unknown status Chemotherapy NCT03453255
Study of Azacitidine Combined With Homoharringtonie Based Regimens in AML Recruiting Acute Myeloid Leukemia NCT04248595
A Study of SKLB1028 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory (R/R) AML With FLT3-Mutated Recruiting Acute Myeloid Leukemia (AML) NCT04716114
Study of DAC Combined With HAAG Regimen in Newly Diagnosed AML Patients Older Than 60 Recruiting Acute Myeloid Leukemia|Induction Chemotherapy NCT04083911
Omacetaxine in Patients With Intermediate-1 and Higher Risk Myelodysplastic Syndrome (MDS) Post Hypomethylating Agent (HMA) Failure Completed Leukemia NCT02159872
Efficacy Study of CHG Regimen vs Decitabine to Treat Higher-risk MDS Unknown status Myelodysplastic Syndromes NCT01417767
Omacetaxine + Azacitidine in Untreated Patients With High Grade MDS Recruiting High Grade Myelodysplastic Syndromes NCT03564873
Omacetaxine and Decitabine in Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS) Terminated Leukemia NCT02141477
Omacetaxine and Venetoclax for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Harboring Mutant RUNX1 Not yet recruiting Hematopoietic and Lymphoid Cell Neoplasm|Recurrent Acute Biphenotypic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Biphenotypic Leukemia|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome NCT04874194
Omacetaxine for Consolidation and Maintenance Terminated Acute Myelogenous Leukemia (AML) NCT01873495
Efficacy of HAD Induction With Intensified Cytarabine in Newly-diagnosed CEBPA Double Mutated Acute Myeloid Leukemia Recruiting CEBPA Double Mutation|Acute Myeloid Leukemia NCT04415008
A Study of Azacitidine for Patients With Int/High -Risk MDS and AML-MRC Recruiting Myelodysplastic Syndromes,Acute Myeloid Leukemia NCT03978364
Study of APG2575 Single Agent and Combination Therapy in Patients With Relapsed/Refractory AML Recruiting Relapsed/Refractory Acute Myeloid Leukaemia|Myeloid Malignancy NCT04501120
Azacytidine + HAG Regimen vs. Azacytidine for Elderly Patients With Newly Diagnosed Myeloid Malignancy Recruiting Acute Myeloid Leukaemia; Myelodysplastic Syndromes;Chronic Myelomonocytic Leukemia NCT03873311
A Clinical Trial of Omacetaxine, Azacitidine, and Growth-Colony Stimulating Factor (G-CSF) for Myelodysplastic Syndromes (MDS) Withdrawn Myelodysplastic Syndromes NCT02835794
A Pivotal Study of HQP1351 in Patients With Chronic Myeloid Leukemia in Chronic Phase Active, not recruiting Chronic Myeloid Leukemia, Chronic Phase NCT04126681
Efficacy and Safety of HVA Regimens as Salvage Treatment in rrAML Enrolling by invitation Refractory Acute Myeloid Leukemia|Relapsed Acute Erythroid Leukemia|Salvage Treatment|HVA Regimen NCT04424147
A Phase 2 Study of Venetoclax in Combination With Low-dose HHT, G-CSF, and AZA as First-line Treatment for Newly Diagnosed Elderly AML Patients Unfit for Intensive Chemotherapy Not yet recruiting Leukemia, Myeloid, Acute NCT04824924
AML-02: Omacetaxine With Standard-of-Care Induction With Cytarabine & Idarubicin in Newly-Diagnosed AML Patients Terminated Acute Myeloid Leukemia NCT02440568
Study of Decitabine Combined With HAAG Regimen in Newly Diagnosed ETP-ALL/LBL, T/M-MPAL and ALL/LBL With Myeloid or Stem Cell Markers Patients Recruiting Induction Chemotherapy|Acute T-Lymphocytic Leukemia|T-cell Lymphoblastic Lymphoma Leukemia|T-cell/Myeloid Mixed Phenotype Acute Leukemia NCT04446130
New Double Epigenetic Regimen in the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Recruiting Acute Myeloid Leukemia|Refractory Acute Leukemia|Relapsed Adult AML NCT05029141
Efficacy Analysis of Comparison of CAMS（Chinese Academy of Medical Sciences）-2005 Trial and CAMS-2009 Trial for Pediatric Acute Myeloid Leukemia Completed Acute Myeloid Leukemia, Pediatric NCT03165851
Study of DAC Combined With HAAG Regimen in Newly Diagnosed Younger AML Patients Recruiting Acute Myeloid Leukemia|Induction Chemotherapy NCT04087967
Safety and Efficacy of Venetoclax With Escalating Doses of Omacetaxine in Patients With Acute Myeloid Leukemia Recruiting Relapsed or Refractory Hematologic Malignancies NCT04926285
Omacetaxine and Low Dose Cytarabine in Older Patients With Acute Myelogenous Leukemia (AML) and High-Risk Myelodysplastic Syndrome (MDS) Completed Leukemia NCT01272245

References

Publication DOI Pubmed PMCID
Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells. European journal of haematology Hongyan Tong, Yanling Ren, Fengjuan Zhang, Jie Jin, 81, 4, None, 2008-07-08, 10.1111/j.1600-0609.2008.01116.x 10.1111/j.1600-0609.2008.01116.x 18616510 18616510
Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Scientific reports Wei Cao, Ying Liu, Ran Zhang, Bo Zhang, Teng Wang, Xianbing Zhu, Lin Mei, Hongbo Chen, Hongling Zhang, Pinghong Ming, Laiqiang Huang, 5, None, 2015-07-13, 2015-07-13, 10.1038/srep08477 10.1038/srep08477 26166037 PMC4499885

Vendors

Company Lnk to product
MERCK/Sigma Aldrich https://www.sigmaaldrich.com/PL/pl/product/sigma/sml1091

Filter data

Compound Homoharringtonine
Experiment types Colony formation assay , Flow cytometry- annexin V binding and propidium iodide staining, Hoechst 33258 assay, MTT, Trypan blue exclusion assay, Tumor volume, Tumor wight , Western Blot
Concentrations 0.12, 0.25, 0.50, 1.00, 10.00, 160.00, 2.00, 20.00, 3.00, 4.00, 40.00, 5.00, 6.00, 60.00, 80.00
Cell lines A549, H1975, H1975 (xenograft), HEL, HL60, K562, Leukemia patient cells
Organisms Homo sapiens, Mus musculus
Animal models
STAT proteins STAT3, STAT5, p-STAT3, p-STAT3 (S727), p-STAT3 (Y705), p-STAT5
Other AKT1/2/3, Actin, BAX, BCL2, Bcl-xL, Caspase 3, Caspase 9, Cytochrome C, EGFR, ERK1/2, GAPDH, JAK1, JAK2, MCL1, PARP, PDK1, Pim-1, Smad2, Smad3, Survivin, c-Myc, p-AKT1/2/3, p-EGFR, p-ERK1/2, p-JAK1, p-JAK2, p-PDK1, p-Smad2, p-Smad3

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Homoharringtonine MTT Influence on cell viability and apoptosis 20.00 ng/ml HEL Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 20.00 ng/ml K562 Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 20.00 ng/ml HL60 Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 40.00 ng/ml HEL Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 40.00 ng/ml K562 Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 40.00 ng/ml HL60 Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 80.00 ng/ml HEL Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 80.00 ng/ml K562 Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 80.00 ng/ml HL60 Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 160.00 ng/ml HEL Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 160.00 ng/ml K562 Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis 160.00 ng/ml HL60 Homo sapiens
Homoharringtonine Flow cytometry- annexin V binding and propidium iodide staining Influence on cell viability and apoptosis 20.00 ng/ml HEL Homo sapiens
Homoharringtonine Flow cytometry- annexin V binding and propidium iodide staining Influence on cell viability and apoptosis 40.00 ng/ml HEL Homo sapiens
Homoharringtonine Flow cytometry- annexin V binding and propidium iodide staining Influence on cell viability and apoptosis 80.00 ng/ml HEL Homo sapiens
Homoharringtonine Flow cytometry- annexin V binding and propidium iodide staining Influence on cell viability and apoptosis 160.00 ng/ml HEL Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis in patients 20.00 ng/ml HEL Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis in patients 40.00 ng/ml HEL Homo sapiens
Homoharringtonine MTT Influence on cell viability and apoptosis in patients 80.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity in patients 20.00 ng/ml Leukemia patient cells Homo sapiens
Homoharringtonine Western Blot Influence on protein activity in patients 40.00 ng/ml Leukemia patient cells Homo sapiens
Homoharringtonine Western Blot Influence on protein activity in patients 20.00 ng/ml Leukemia patient cells Homo sapiens
Homoharringtonine Western Blot Influence on protein activity in patients 40.00 ng/ml Leukemia patient cells Homo sapiens
Homoharringtonine Western Blot Influence on protein activity in patients 20.00 ng/ml Leukemia patient cells Homo sapiens STAT5
Homoharringtonine Western Blot Influence on protein activity in patients 40.00 ng/ml Leukemia patient cells Homo sapiens STAT5
Homoharringtonine Western Blot Influence on protein activity in patients 20.00 ng/ml Leukemia patient cells Homo sapiens p-STAT5
Homoharringtonine Western Blot Influence on protein activity in patients 40.00 ng/ml Leukemia patient cells Homo sapiens p-STAT5
Homoharringtonine Western Blot Influence on protein activity in patients 20.00 ng/ml Leukemia patient cells Homo sapiens
Homoharringtonine Western Blot Influence on protein activity in patients 40.00 ng/ml Leukemia patient cells Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml HEL Homo sapiens STAT5
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml HEL Homo sapiens STAT5
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml HEL Homo sapiens STAT5
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml HEL Homo sapiens p-STAT5
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml HEL Homo sapiens p-STAT5
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml HEL Homo sapiens p-STAT5
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml K562 Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml K562 Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml K562 Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml K562 Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml K562 Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml K562 Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml K562 Homo sapiens STAT5
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml K562 Homo sapiens STAT5
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml K562 Homo sapiens STAT5
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml K562 Homo sapiens p-STAT5
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml K562 Homo sapiens p-STAT5
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml K562 Homo sapiens p-STAT5
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml K562 Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml K562 Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml K562 Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 20.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 40.00 ng/ml HEL Homo sapiens
Homoharringtonine Western Blot Influence on protein activity 60.00 ng/ml HEL Homo sapiens
Homoharringtonine Flow cytometry- annexin V binding and propidium iodide staining Influence on cell viability 20.00 ng/ml HEL Homo sapiens
Homoharringtonine Flow cytometry- annexin V binding and propidium iodide staining Influence on cell viability 40.00 ng/ml K562 Homo sapiens
Homoharringtonine MTT Influence on cell viability 1.00 µM A549 Homo sapiens
Homoharringtonine MTT Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine MTT Influence on cell viability 3.00 µM A549 Homo sapiens
Homoharringtonine MTT Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine MTT Influence on cell viability 5.00 µM A549 Homo sapiens
Homoharringtonine MTT Influence on cell viability 6.00 µM A549 Homo sapiens
Homoharringtonine MTT Influence on cell viability 0.12 µM H1975 Homo sapiens
Homoharringtonine MTT Influence on cell viability 0.25 µM H1975 Homo sapiens
Homoharringtonine MTT Influence on cell viability 0.50 µM H1975 Homo sapiens
Homoharringtonine MTT Influence on cell viability 1.00 µM H1975 Homo sapiens
Homoharringtonine MTT Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine MTT Influence on cell viability 3.00 µM H1975 Homo sapiens
Homoharringtonine Trypan blue exclusion assay Influence on cell viability 0.50 µM H1975 Homo sapiens
Homoharringtonine Trypan blue exclusion assay Influence on cell viability 1.00 µM H1975 Homo sapiens
Homoharringtonine Trypan blue exclusion assay Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine Colony formation assay Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine Colony formation assay Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine Colony formation assay Influence on cell viability 1.00 µM A549 Homo sapiens
Homoharringtonine Colony formation assay Influence on cell viability 4.00 µM H1975 Homo sapiens
Homoharringtonine Colony formation assay Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine Colony formation assay Influence on cell viability 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine Hoechst 33258 assay Influence on cell apoptosis 1.00 µM A549 Homo sapiens
Homoharringtonine Hoechst 33258 assay Influence on cell apoptosis 2.00 µM A549 Homo sapiens
Homoharringtonine Hoechst 33258 assay Influence on cell apoptosis 3.00 µM A549 Homo sapiens
Homoharringtonine Hoechst 33258 assay Influence on cell apoptosis 4.00 µM A549 Homo sapiens
Homoharringtonine Hoechst 33258 assay Influence on cell apoptosis 1.00 µM H1975 Homo sapiens
Homoharringtonine Hoechst 33258 assay Influence on cell apoptosis 2.00 µM H1975 Homo sapiens
Homoharringtonine Hoechst 33258 assay Influence on cell apoptosis 3.00 µM H1975 Homo sapiens
Homoharringtonine Hoechst 33258 assay Influence on cell apoptosis 4.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell apoptosis 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on cell viability 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens p-STAT3 (Y705)
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens p-STAT3 (Y705)
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens p-STAT3 (Y705)
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens p-STAT3 (Y705)
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens p-STAT3 (Y705)
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens p-STAT3 (Y705)
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens p-STAT3 (S727)
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens p-STAT3 (S727)
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens p-STAT3 (S727)
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens p-STAT3 (S727)
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens p-STAT3 (S727)
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens p-STAT3 (S727)
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 4.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 0.50 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity 2.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 1.00 µM A549 Homo sapiens p-STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 5.00 µM A549 Homo sapiens p-STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 10.00 µM A549 Homo sapiens p-STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 1.00 µM H1975 Homo sapiens p-STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 5.00 µM H1975 Homo sapiens p-STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 10.00 µM H1975 Homo sapiens p-STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 1.00 µM A549 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 5.00 µM A549 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 10.00 µM A549 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 1.00 µM H1975 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 5.00 µM H1975 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 10.00 µM H1975 Homo sapiens STAT3
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 1.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 5.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 10.00 µM A549 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 1.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 5.00 µM H1975 Homo sapiens
Homoharringtonine Western Blot Influence on protien activity in presence of IL-6 10.00 µM H1975 Homo sapiens
Homoharringtonine Tumor volume Influence on cell proliferation in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus
Homoharringtonine Tumor wight Influence on cell proliferation in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus
Homoharringtonine Western Blot Influence on protien activity in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus p-STAT3
Homoharringtonine Western Blot Influence on protien activity in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus STAT3
Homoharringtonine Western Blot Influence on protien activity in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus
Homoharringtonine Western Blot Influence on protien activity in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus
Homoharringtonine Western Blot Influence on protien activity in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus
Homoharringtonine Western Blot Influence on protien activity in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus
Homoharringtonine Western Blot Influence on protien activity in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus
Homoharringtonine Western Blot Influence on protien activity in tumor tissue 10.00 mg/kg H1975 (xenograft) Mus musculus