HO-3867

Name Value
Weight 464.556 g/mol
Zinc ID ZINC114897816
Smiles CC1(C)C=C(CN2C/C(=C/c3ccc(F)cc3)C(=O)/C(=C/c3ccc(F)cc3)C2)C(C)(C)N1O
Molecular formula C28H30F2N2O2
Mode of inhibition Direct STAT DBD; Curcumin analog
CAS 1172133-28-6

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anti-cancer drugs Yan Hu, Chengguang Zhao, Hailun Zheng, Kongqin Lu, Dengjian Shi, Zhiguo Liu, Xuanxuan Dai, Yi Zhang, Xiuhua Zhang, Wanle Hu, Guang Liang, 28, 4, None, None, 10.1097/CAD.0000000000000470 10.1097/CAD.0000000000000470 28067673 28067673

Vendors

Company Lnk to product
Caymanchemical https://www.caymanchem.com/product/21581/ho-3867
Selleckchem https://www.selleckchem.com/products/ho-3867.html
MedChemExpress https://www.medchemexpress.com/HO-3867.html

Filter data

Compound HO-3867
Experiment types Flow cytometry , Western Blot
Concentrations 0.50, 1.00, 2.00
Cell lines BXPC-1, Panc-1
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3
Other ATF-4, Bax, Bcl-2, Cleaved PARP, ERK, GAPDH, JNK, P-eif2a, eif2a, p-38, p-ERK, p-JNK, p-p-ERK, p-p38, pro-caspase-3

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
HO-3867 Western Blot Influence on apoptosis 0.50 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 1.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 0.50 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 1.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 0.50 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 1.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 0.50 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 1.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 0.50 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 1.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on apoptosis 2.00 µM Panc-1 Homo sapiens
HO-3867 Flow cytometry Influence on ROS generation 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM BXPC-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM BXPC-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM BXPC-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM BXPC-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM BXPC-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM BXPC-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM BXPC-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM BXPC-1 Homo sapiens
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens p-STAT3
HO-3867 Western Blot Influence on protein activity 2.00 µM Panc-1 Homo sapiens STAT3
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens p-STAT3
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM Panc-1 Homo sapiens STAT3
HO-3867 Western Blot Influence on protein activity 2.00 µM BXPC-1 Homo sapiens p-STAT3
HO-3867 Western Blot Influence on protein activity 2.00 µM BXPC-1 Homo sapiens STAT3
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM BXPC-1 Homo sapiens p-STAT3
HO-3867 Western Blot Influence on protein activity i presence of NAC 2.00 µM BXPC-1 Homo sapiens STAT3