HJC0123

Name Value
Weight 412.470 g/mol
Zinc ID ZINC95592154
Smiles O=C(C1=CC(C2=CC=CC=C2)=NC3=CC=CC=C13)NC4=CC=C(C=CS5(=O)=O)C5=C4
Molecular formula N/A
Mode of inhibition Direct STAT
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
STAT3 Inhibition Suppresses Hepatic Stellate Cell Fibrogenesis: HJC0123, a Potential Therapeutic Agent for Liver Fibrosis. RSC advances Omar Nunez Lopez, Fredrick J Bohanon, Xiaofu Wang, Na Ye, Tiziana Corsello, Yesenia Rojas-Khalil, Haijun Chen, Haiying Chen, Jia Zhou, Ravi S Radhakrishnan, 6, 102, None, 2016-10-14, 10.1039/C6RA17459K 10.1039/C6RA17459K 28546859 PMC5440088

Vendors

Company Lnk to product
Glixxlabs http://glixxlabs.com/chemical-products/bioactive-screen-leads-p6/GLXC-04975

Filter data

Compound HJC0123
Experiment types Alamar Blue assay, Flow cytometry , Immunofluorescence staining , Influence on protein activity, Luciferase reporter assay , Western Blot
Concentrations 0.50, 1.00, 1.50, 2.00, N/A
Cell lines C3A, HSC-T6, LX-2
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3 (Y705), p-STAT3 (cytosolic), p-STAT3 (nuclear)
Other Bcl-2, Collagen I, Cyclin D1, Fibronectin, GAPDH, JNK, Lamin B (cytosolic), Lamin B (nuclear), SOCS3, Smad 2/3, Tubulin, c-myc, p-JNK, p-Smad 2/3, α-SMA

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
HJC0123 Alamar Blue assay Influence on cell viability N/A µM HSC-T6 Homo sapiens
HJC0123 Alamar Blue assay Influence on cell viability N/A µM C3A Homo sapiens
HJC0123 Alamar Blue assay Influence on cell viability N/A µM LX-2 Homo sapiens
HJC0123 Influence on protein activity Influence on protein activity 1.00 µM LX-2 Homo sapiens p-STAT3 (Y705)
HJC0123 Influence on protein activity Influence on protein activity 1.00 µM LX-2 Homo sapiens STAT3
HJC0123 Influence on protein activity Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Influence on protein activity Influence on protein activity 1.00 µM LX-2 Homo sapiens p-STAT3 (nuclear)
HJC0123 Influence on protein activity Influence on protein activity 1.00 µM LX-2 Homo sapiens p-STAT3 (cytosolic)
HJC0123 Influence on protein activity Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Influence on protein activity Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Influence on protein activity Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Luciferase reporter assay Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Luciferase reporter assay Influence on protein activity 2.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 0.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 2.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 0.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 2.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 0.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 2.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 0.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 2.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 0.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 2.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 0.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 2.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 0.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity 2.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity in presence of TGF-β 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity in presence of TGF-β 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on protein activity in presence of TGF-β 1.00 µM LX-2 Homo sapiens
HJC0123 Flow cytometry Influence on cell cycle 1.00 µM LX-2 Homo sapiens
HJC0123 Immunofluorescence staining Influence on cell cycle 1.00 µM LX-2 Homo sapiens
HJC0123 Immunofluorescence staining Influence on cell cycle 0.50 µM LX-2 Homo sapiens
HJC0123 Immunofluorescence staining Influence on cell cycle 1.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on cell activation 1.00 µM LX-2 Homo sapiens
HJC0123 Immunofluorescence staining Influence on cell activation 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on cell activation 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on cell activation 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on cell activation 0.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on cell activation 1.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on cell activation 0.50 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on cell activation 1.00 µM LX-2 Homo sapiens
HJC0123 Western Blot Influence on cell activation 1.50 µM LX-2 Homo sapiens