Gefitinib

Name Value
Weight 446.910 g/mol
Zinc ID ZINC19632614
Smiles COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Molecular formula C22H24ClFN4O3
Mode of inhibition STAT
CAS 184475-35-2

Clinical Trials

Study title Status Conditions Link
S-1 Plus Gefitinib Versus Gefitinib Monotherapy in Patients With EGFR-sensitive Mutation Advanced Non-squamous NSCLC Not yet recruiting EGFR-sensitive Mutation-positive Advanced Non-squamous Non-small Cell Lung Cancer Treated With S-1plus Gefitinib Versus Gefitinib Monotherapy NCT03457337
PRe-Operative Gefitinib in Resectable EGFR Mutation Positive Lung Cancer With Sector Sequencing for Biomarker Discovery Recruiting Non-small Cell Lung Cancer NCT02804776
Bone Metastasis on the Survival of Gefitinib Effective Patients Completed Overal Survival, Non-small Cell Lung Cancer NCT03157310
Osimertinib and Gefitinib in EGFR Inhibitor naĂŻve Advanced EGFR Mutant Lung Cancer Recruiting Non-Small Cell Lung Cancer NCT03122717
First Line Gefitinib by FDG-PET Metabolic Response Unknown status Non-small Cell Lung Cancer NCT01510990
Gefitinib and Berberine in the First-line Treatment of Lung Adenocarcinoma With EGFR Mutation Unknown status Lung Adenocarcinoma|EGFR Mutation NCT03486496
Gefitinib Combine Radiotherapy as Therapy for Patients With NSCLC Harbouring Sensitive Mutations of EGFR Not yet recruiting Lung Cancer NCT03381430
ASK120067 Versus Gefitinib as First-line Treatment for EGFRm Locally Advanced or Metastatic NSCLC Recruiting Locally Advanced or Metastatic NSCLC NCT04143607
Blood Detection of EGFR Mutation For Iressa Treatment Unknown status Lung Adenocarcinoma NCT02282267
A Study of EGF816 and Gefitinib in TKI-naĂŻve EGFR-mutant Non-Small Cell Lung Cancer Recruiting Lung Cancer NCT03292133
A Study of Gefitinib With or Without Apatinib in Patients With Advanced Non-squamous Non-Small-Cell Lung Cancer Harboring EGFR Mutations Recruiting EGFR Tyrosine Kinase Inhibitors Plus VEGFR Inhibitors NCT02824458
Preoperative Gefitinib for EGFR Mutant II-IIIa NSCLC Unknown status Non-small-cell Lung Cancer NCT01833572
Study of Gefitinib Retreatment in Non-Small Cell Lung Cancer (NSCLC) Completed Carcinoma, Non-Small-Cell Lung NCT00824746
High-Dose,Pulsatile Erlotinib/Gefitinib for Advanced NSCLC Patients After Failure of Standard Dose EGFR-TKIs Unknown status Self Efficacy|Drug Toxicity NCT01965275
Hydroxychloroquine and Gefitinib to Treat Lung Cancer Unknown status Non-small Cell Lung Cancer NCT00809237
Gefitinib in Combination With Anlotinib or Placebo in Previously Untreated EGFR-mutant NSCLC Recruiting Lung Cancer, Nonsmall Cell NCT04028778
Third-line Treatment of Gefitinib in NSCLC Patients Completed Non Small Cell Lung Cancer NCT01933347
Iressa Re-Challenge in Advanced NSCLC EGFR M+ Patients Who Responded to Gefitinib USed as 1st Line or Previous Treatment Completed Lung Cancer NCT01530334
Ningetinib (CT053PTSA) Plus Gefitinib in Stage IIIB or IV NSCLC Patients With EGFR Mutation and T790M Negative Recruiting Non-small Cell Lung Cancer NCT03758287
A Phase II Study of Fruquintinib in Combination With Gefitinib in Patients With Advanced Non-small Cell Lung Cancer Completed NSCLC NCT02976116
Bioequivalence Study of Gefitinib Tablets Under Fed Conditions Completed Healthy NCT03050177
The Continuation of Gefitinib Treatment Beyond Progression in Non-small Cell Lung Cancer Patients With EGFR Mutation Unknown status Non-small Cell Lung Cancer NCT03399669
Bioequivalence Study of Gefitinib Tablets Under Fasting Conditions Completed Bioequivalence Study NCT03050164
NEoadjuvant Gefitinib fOllowed by Surgery and gefiTinib In unresectAble sTage III NSCLC With EGFR Mutations. Recruiting Lung Cancer NCT02347839
Epidermal Growth Factor Receptor (EGFR) Status Based Gefitinib Neoadjuvant Therapy in Non Small Cell Lung Cancer (NSCLC) Suspended Non Small Cell Lung Cancer NCT00986284
Gefitinib Versus Vinorelbine/Platinum as Adjuvant Treatment in Stage II-IIIA(N1-N2) NSCLC With EGFR Mutation Active, not recruiting Non-small Cell Lung Cancer NCT01405079
Chemotherapy Plus Gefitinib for Advanced Lung Adenocarcinoma and Sensitive EGFR Mutations: a Randomized Controlled Trial Unknown status Lung Adenocarcinoma NCT02951637
Efficacy and Safety Study of Gefitinib in Squamous NSCLC Patients Who Failed First-Line Chemotherapy Unknown status Squamous Cell Carcinoma of Bronchus NCT01485809
High Dose Gefitinib for the Treatment of Carcinomatous Meningitis in Adult Patients With Non-Small Cell Lung Cancer and Known or Suspected EGFR Mutations Completed Non-Small Cell Lung Cancer NCT00372515
Phase II Study of Gefitinib Plus Nimotuzumab Versus Gefitinib in Non-small Cell Lung Cancer Completed Non Small Cell Lung Cancer (NSCLC) NCT01498562
Phase I of Vorinostat-Iressa Combined Therapy on Resistance by BIM Polymorphysim in EGFR Mutant Lung Cancer Unknown status Non-Small-Cell Lung Carcinoma NCT02151721
Tolerability and Efficacy of Tremelimumab in Combination With Gefitinib in NSCLC Patients Completed Non Small Cell Lung Cancer NCT02040064
DS-1205c With Gefitinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer Active, not recruiting Non Small Cell Lung Cancer NCT03599518
Gefitinib or Docetaxel as Second Line Therapy for Wild-type Epidermal Growth Factor Receptor (EGFR) NSCLC Unknown status Non-small Cell Lung Cancer NCT01755923
Study of Iressa in Patients With Relapsed or Refractory Acute Myelogenous Leukemia Completed Myelogenous Leukemia, Acute NCT00130702
Pemetrexed Combined With Synchronous Gefitinib as Adjuvent Therapy in Patient With EGFR Mutant Lung Adenocarcinoma Unknown status Lung Neoplasms NCT02518802
Phase I Study of the Combination of Anlotinib With Gefitinib Not yet recruiting Non-squamous Non-small Cell Lung Cancer NCT03602027
The Safety and Effects of Gefitinib in Triple-negative,EGFR Positive Metastatic Breast Cancer Unknown status Breast Cancer NCT01732276
Assess the Efficacy, Safety and Tolerability of Gefitinib (Iressa® 250mg) as Maintenance Therapy in Locally Advanced or Metastatic (Stage IIIB/IV) Non Small Cell Lung Cancer (NSCLC) Completed Non-small Cell Lung Cancer (NSCLC) NCT00770588
Phase II Study of Skin Toxicity Dosing of IRESSA (Gefitinib) in Squamous Cell Carcinoma of the Head and Neck Completed Head and Neck Neoplasms NCT00519077
A Trial of Gefitinib in Combination With BKM120 in Patients With Advanced Non-Small Cell Lung Cancer, With Enrichment for Patients Whose Tumours Harbour Molecular Alterations of PI3K Pathway and Known to Overexpress EGFR Active, not recruiting Non-Small Cell Lung Cancer|Solid Tumors NCT01570296
CIK Cell Transfusion Plus Gefitinib As Second Or Third-Line Treatment for Advanced Adenocarcinoma Non-Small Cell Lung Cancer Terminated Non-Small Cell Lung Cancer NCT01871480
A Study Of Nasopharyngeal Carcinoma (NPC) Treated With Celecoxib And ZD1839 Completed Nasopharyngeal Carcinoma NCT00212108
Vinorelbine-ifosfamide Versus Gefitinib for EGFR Gene Mutation Negative Non-small Cell Lung Cancer Patients Unknown status Non-small Cell Lung Cancer|Effects of Chemotherapy NCT01749072
Efficacy, Safety, Tolerability of Gefitinib as 1st Line in Caucasian Patients With EGFR Mutation Positive Advanced NSCLC Completed Caucasian Patients With EGFR Mutation Positive Advanced NSCLC NCT01203917
Gefitinib Combined With Radiotherapy in Elderly Patients With Esophageal Cancer Unknown status Esophageal Cancer NCT01291823
Efficacy of Gefitinib for Brain Metastasis of Non-Small Cell Lung Cancer Unknown status Non-Small Cell Lung Cancer|Brain Metastasis NCT00614809
the Clinical Trial of Gefitinib(Non - Small Cell Lung Cancer) Not yet recruiting Non-small Cell Lung Cancer NCT03264794
Gefitinib With or Without Pemetrexed/Cisplatin in Brain Metastases From Non-small Cell Lung Cancer Unknown status Non-small Cell Lung Cancer|Brain Metastases|EGFR Mutation NCT01951469
Study With Gefitinib in Combination With Olaparib (AZD2281) Versus Gefitinib Alone Completed Non Small Cell Lung Cancer NCT01513174
Radiotherapy Combined With Iressa for EGFR Mutation Positive Patients With Locally Advanced Non-small Cell Lung Cancer (NSCLC) Unknown status Non-small Cell Lung Cancer NCT01391260
GEfitinib Plus viNOrelbine in Advanced EGFR Mutated NSCLC. GENOA Trial Unknown status Non Small Cell Lung Cancer NCT02319577
ARCHER1050: A Study of Dacomitinib vs. Gefitinib in 1st-Line Treatment Of Advanced NSCLC. Active, not recruiting Non-small Cell Lung Cancer With EGFR-Activating Mutations NCT01774721
Gefitinib 500mg Versus 250mg in Patients With NSCLC With Stable Disease After a Month Treatment of Gefitinib 250mg Completed Non-small Cell Lung Cancer NCT01017679
Postoperative Radiotherapy Plus Iressa or Radiotherapy Plus Cisplatin and Iressa for Advanced Head & Neck Cancer Completed Head and Neck Cancer NCT00681967
Dose Defining Study For MK-2206 Combined With Gefitinib In Non Small Cell Lung Cancer (NSCLC) Unknown status Non Small Cell Lung Cancer NCT01147211
Real World Study on Erlotinib/Gefitinib Combined With Bevacizumab in Advanced Non-aquamous Non-small Cell Lung Cancer Recruiting Non Small Cell Lung Cancer NCT03647592
Phase III Trial to Evaluate the Elortinib vs Gefitinib in Advanced NSCLC With EGFR Exon 19 or 21 Mutations Completed Thoracic Neoplasms NCT01024413
Gefitinib Combined With Chemotherapy or Antiangiogensis in Patients With Bim Deletion or Low EGFR Mutation Abundance Unknown status Non-small-cell Lung Cancer NCT02930954
Gefitinib With Chemotherapy or Anti-angiogenesis in NSCLC Patients With Bim Deletion or Low EGFR Mutation Abundance Unknown status Non-small-cell Lung Cancer NCT03267654
Intercalating and Maintenance Use of Iressa Versus Chemotherapy in Selected Advanced Non Small Cell Lung Cancer Completed Non-small Cell Lung Cancer NCT01404260
Gefitinib and Etoposide in Treating Patients With Advanced Prostate Cancer That Did Not Respond to Hormone Therapy Terminated Prostate Cancer NCT00483561
Iressa Study in Patients With Salivary Gland Cancer Completed Salivary Gland Cancer NCT00509002
Gefitinib Versus Pemetrexed for Previously Treated NSCLC Patients Completed Previous Treated Metastatic Non-small Cell Lung Cancer NCT01783834
A Study of Pemetrexed and Gefitinib Versus Gefitinib in Non-Small Cell Lung Cancer (NSCLC) Completed Carcinoma, Non Small Cell Lung NCT01469000
Gefitinib in Treating Patients With Recurrent or Metastatic Esophageal or Gastroesophageal Junction Cancer Completed Esophageal Cancer NCT00268346
Gefitinib in Treating Patients With Advanced Unresectable Hepatocellular Carcinoma (Liver Cancer) Completed Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Localized Unresectable Adult Primary Liver Cancer|Recurrent Adult Primary Liver Cancer NCT00071994
Gefitinib With or Without Simvastatin in Non-Small Cell Lung Cancer (NSCLC) Completed Lung Cancer NCT00452244
Study Of SU011248 Plus Gefitinib (Iressa) In Patients With Advanced Renal Cell Carcinoma Completed Carcinoma, Renal Cell NCT00113529
Targeted Therapy With Gefitinib in Patients With USP8-mutated Cushing's Disease Unknown status Cushing's Disease|Corticotrophin Adenoma NCT02484755
Phase 2 Study Of Neoadjuvant Iressa Treatment In Stage 1 NSCLC Completed LUNG CANCER NCT00188617
Study to Evaluate the Safety and Efficacy of Gefitinib, in Subjects With EFGR Amplification Refractory Solid Tumors Recruiting Solid Tumor NCT02447419
Topotecan and Gefitinib (Iressa) for Ovarian, Peritoneal, or Fallopian Tube Cancer Active, not recruiting Ovarian Cancer|Peritoneal Neoplasms|Fallopian Tube Cancer NCT00317772
A Feasibility Study With Iressa in Resistant Cytokeratin-Positive Tumor Cells Circulating in the Blood of Women With Breast Cancer Completed Breast Cancer NCT00428896
Combination of Chemotherapy and Gefitinib as First-line Treatment Completed Non-Small-Cell Lung Cancer NCT02148380
Comparator-Controlled Study for EGFR(+) Patients With Multiple BMs From NSCLC (BROKE) (EGFR-epidermal Growth Factor Receptor;BM-brain Metastases) Unknown status Non-Small Cell Lung Cancer|Brain Metastases|EGFR Gene Mutation NCT02338011
Iressa Follow-up Trial Completed Lung Cancer|Breast Cancer NCT00357734
A Phase I Study of Safety and Pharmacokinetics of Volitinib in Combination With Gefitinib in EGFR(+) NSCLC Active, not recruiting Non-Small Cell Lung Cancer NCT02374645
Intercalating and Maintenance Gefitinib in Combination With Chemotherapy for Advanced EGFR-mutant NSCLC Terminated Non-small Cell Lung Cancer Metastatic|EGFR Activating Mutation NCT02299765
Pemetrexed/Cisplatin Intercalating Gefitinib Treating EGFR Wild NSCLC Recruiting Non Small Cell Lung Cancer NCT03374280
Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene Completed Lung Cancer|Non-small Cell Lung Cancer|Bronchioloalveolar Cancer NCT00588445
Gefitinib in Treating Children With Refractory Solid Tumors Completed Unspecified Childhood Solid Tumor, Protocol Specific NCT00040781
Gefitinib Usage and Outcomes in Routine Treatment Completed Lung Cancer NCT01818947
Study Evaluating Gefitinib (IRESSA®) in Subjects With Solid Malignancies That Are Locally Advanced, Recurrent or Metastatic Completed Tumors NCT00127829
Alflutinib Mesylate Versus Gefitinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (FLAG) Active, not recruiting Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non-small Cell Lung Cancer NCT03787992
Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer Completed Anaplastic Thyroid Cancer|Insular Thyroid Cancer|Metastatic Parathyroid Cancer|Recurrent Adenoid Cystic Carcinoma of the Oral Cavity|Recurrent Basal Cell Carcinoma of the Lip|Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity|Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity|Recurrent Lymphoepithelioma of the Nasopharynx|Recurrent Lymphoepithelioma of the Oropharynx|Recurrent Metastatic Squamous Neck Cancer With Occult Primary|Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity|Recurrent Mucoepidermoid Carcinoma of the Oral Cavity|Recurrent Non-small Cell Lung Cancer|Recurrent Parathyroid Cancer|Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Recurrent Thyroid Cancer|Recurrent Verrucous Carcinoma of the Larynx|Stage III Follicular Thyroid Cancer|Stage III Papillary Thyroid Cancer|Stage III Salivary Gland Cancer|Stage III Squamous Cell Carcinoma of the Hypopharynx|Stage III Squamous Cell Carcinoma of the Larynx|Stage III Verrucous Carcinoma of the Larynx|Stage IIIB Non-small Cell Lung Cancer|Stage IV Lymphoepithelioma of the Nasopharynx|Stage IV Non-small Cell Lung Cancer|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity|Stage IVA Basal Cell Carcinoma of the Lip|Stage IVA Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity|Stage IVA Follicular Thyroid Cancer|Stage IVA Inverted Papilloma of the Paranasal Sinus and Nasal Cavity|Stage IVA Lymphoepithelioma of the Oropharynx|Stage IVA Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity|Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity|Stage IVA Papillary Thyroid Cancer|Stage IVA Salivary Gland Cancer|Stage IVA Squamous Cell Carcinoma of the Larynx|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Oropharynx|Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVA Verrucous Carcinoma of the Larynx|Stage IVA Verrucous Carcinoma of the Oral Cavity|Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity|Stage IVB Basal Cell Carcinoma of the Lip|Stage IVB Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity|Stage IVB Follicular Thyroid Cancer|Stage IVB Inverted Papilloma of the Paranasal Sinus and Nasal Cavity|Stage IVB Lymphoepithelioma of the Oropharynx|Stage IVB Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity|Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity|Stage IVB Papillary Thyroid Cancer|Stage IVB Salivary Gland Cancer|Stage IVB Squamous Cell Carcinoma of the Larynx|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Oropharynx|Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVB Verrucous Carcinoma of the Larynx|Stage IVB Verrucous Carcinoma of the Oral Cavity|Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity|Stage IVC Basal Cell Carcinoma of the Lip|Stage IVC Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity|Stage IVC Follicular Thyroid Cancer|Stage IVC Inverted Papilloma of the Paranasal Sinus and Nasal Cavity|Stage IVC Lymphoepithelioma of the Oropharynx|Stage IVC Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity|Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity|Stage IVC Papillary Thyroid Cancer|Stage IVC Salivary Gland Cancer|Stage IVC Squamous Cell Carcinoma of the Larynx|Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Oropharynx|Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVC Verrucous Carcinoma of the Larynx|Stage IVC Verrucous Carcinoma of the Oral Cavity|Thryoid Gland Nonmedullary Carcinoma|Thyroid Gland Medullary Carcinoma|Tongue Cancer|Untreated Metastatic Squamous Neck Cancer With Occult Primary NCT00068497
LUX-Lung 7: A Phase IIb Trial of Afatinib(BIBW2992) Versus Gefitinib for the Treatment of 1st Line EGFR Mutation Positive Adenocarcinoma of the Lung Completed Lung Neoplasms NCT01466660
Iressa for EGFR Mutation Negative Non-small Cell Lung Cancer (NSCLC) Unknown status Nonsmall Cell Lung Cancer NCT01312337
A Phase 1b/2 Study in Asian Subjects With Non-Small Cell Lung Cancer Completed Carcinoma, Non-Small Cell-Lung|Lung Neoplasms|Lung Cancer|Respiratory Tract Neoplasms NCT01039948
Neoadjuvant IRESSA As Single Agent PreopTherapy for NSCLC With Molecular Correlates Terminated Lung Cancer NCT00104728
Clinical Value of Sequential Gefitinib With Pemetrexed/Platinum for Advanced NSCLC Completed NSCLC NCT01769066
Gefitinib in Treating Patients Who Are Undergoing Surgery and/or Radiation Therapy for Locally Advanced or Recurrent Squamous Cell Skin Cancer Completed Recurrent Skin Cancer|Squamous Cell Carcinoma of the Skin NCT00126555
Combination of Metformin With Gefitinib to Treat NSCLC Completed NSCLC|EGFR Gene Amplification|Advanced Cancer|Stage IIIB NSCLC|Stage IV NSCLC NCT01864681
MEDI4736 (Anti PD-L1) Combined With Gefitinib in Subjects With Non-Small Cell Lung Cancer(NSCLC). Active, not recruiting Carcinoma, Non-Small-Cell Lung NCT02088112
First Line IRESSA™ Versus Carboplatin/Paclitaxel in Asia Completed Non-Small Cell Lung Cancer NCT00322452
Arimidex/Faslodex/Iressa Study: A Trial Using Arimidex, Faslodex and Iressa in Women With Breast Cancer Terminated BREAST CANCER NCT00206414
Gefitinib in Treating Patients With Persistent or Recurrent Endometrial Cancer Completed Recurrent Uterine Corpus Carcinoma NCT00027690
Clinical Study of YYJD Decoction Combined With Gefitinib in Advanced Pulmonary Adenocarcinoma Enrolling by invitation Cancer NCT02929693
A Phase II Study of 250-mg ZD1839 Monotherapy in Recurrent or Metastatic or Both Recurrent and Metastatic Squamous Cell Carcinoma Completed Head and Neck Cancer NCT01185158
A Phase III, Randomized, Multi-center Study to Determine the Efficacy of the Intercalating Combination Treatment of Chemotherapy and Gefitinib or Chemotherapy as Adjuvant Treatment in NSCLC With Common EGFR Mutations. Recruiting Completely Resected NSCLC With Common EGFR Mutations NCT03381066
Gefitinib in Treating Patients With Malignant Mesothelioma Completed Advanced Malignant Mesothelioma|Epithelial Mesothelioma|Recurrent Malignant Mesothelioma|Sarcomatous Mesothelioma NCT00025207
A Study of ASP8273 vs. Erlotinib or Gefitinib in First-line Treatment of Patients With Stage IIIB/IV Non-small Cell Lung Cancer Tumors With EGFR Activating Mutations Terminated Non-small Cell Lung Cancer (NSCLC) NCT02588261
Pharmocokinetic/Pharmacodynamic (PK/PD) Study of the Combination Cetuximab/Gefitinib Completed Colorectal Cancer|Head and Neck Cancer|Non Small Cell Lung Cancer (NSCLC) NCT00820417
Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas Completed Untreated Childhood Anaplastic Astrocytoma|Untreated Childhood Anaplastic Oligodendroglioma|Untreated Childhood Brain Stem Glioma|Untreated Childhood Giant Cell Glioblastoma|Untreated Childhood Glioblastoma|Untreated Childhood Gliomatosis Cerebri|Untreated Childhood Gliosarcoma|Untreated Childhood Oligodendroglioma NCT00042991
Gefitinib in Treating Patients With Locally Advanced or Metastatic Thyroid Cancer That Did Not Respond to Iodine Therapy Completed Head and Neck Cancer NCT00095836
Gefitinib and Radiation Therapy in Treating Patients With Glioblastoma Multiforme Completed Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma NCT00052208
Gefitinib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer Completed Bronchoalveolar Cell Lung Cancer|Recurrent Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer NCT00029003
Study of Gefitinib and Docetaxel as Salvage Therapy in Advanced Pancreatic Carcinoma Completed Cancer NCT00177242
Gefitinib and Everolimus in Treating Patients With Stage IIIB or Stage IV or Recurrent Non-Small Cell Lung Cancer Completed Lung Cancer NCT00096486
Clinical Trial of Neoadjuvant Targeted Treatment to NSCLC Patients Not yet recruiting 2-year Disease-Free Survival NCT03203590
A Study of SH-1028 Tablets Versus Gefitinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Not yet recruiting Non-Small Cell Lung Cancer NCT04239833
Open Label Extension Study With Gefitinib (IRESSA™) for Completing Trial Patients Who May Benefit From Further Treatment Approved for marketing Non Small Cell Lung Cancer (NSCLC) NCT00683306
Gefitinib Combined With Thalidomide to Treat NSCLC Unknown status NSCLC NCT02387086
Phase III Study of Nazartinib (EGF816) Versus Erlotinib/Gefitinib in First-line Locally Advanced / Metastatic NSCLC With EGFR Activating Mutations Withdrawn Carcinoma, Non-small Cell Lung NCT03529084
Trastuzumab and Gefitinib in Treating Patients With Metastatic Breast Cancer Completed Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer NCT00024154
Study of Pemetrexed Versus Gefitinib in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer Who Have Previously Received Platinum-Based Chemotherapy Without Epidermal Growth Factor Receptor (EGFR) Mutations Completed Non Small Cell Lung Cancer NCT00891579
First-line Treatment for Adenocarcinoma Patients With Epidermal Growth Factor Receptor (EGFR) Mutation Completed Pulmonary Cancer NCT00344773
Gefitinib in Treating Patients With Previously Untreated Stage IIIB or Stage IV Non-Small Cell Lung Cancer Completed Lung Cancer NCT00411047
Comparing Anastrozole-Placebo to the Combination Anastrozole-ZD1839 in Postmenopausal Patients With Estrogen Receptor and/or Progesterone Receptor Metastatic Breast Cancer Completed Breast Cancer NCT00077025
Erlotinib 100mg qd Versus Gefitinib 250mg qd for EGFR Mutant Nsclc Unknown status Advanced Stage Non Small Cell Lung Cancer NCT01955421
Study to Assess Safety/Tolerability/Efficacy of Gefitinib Versus Docetaxel in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) Terminated Carcinoma, Non-Small-Cell Lung NCT00536107
Randomized Gefitinib Trial Completed Non Small Cell Lung Cancer NCT00807066
Gefitinib in Treating Patients With Locally Advanced Esophageal Cancer Completed Esophageal Cancer NCT00100945
Iressa v BSC (Best Supportive Care) in First Line NSCLC Completed NSCLC NCT00259064
Trial of Induction Chemotherapy With Carboplatin and Paclitaxel, Followed by Concurrent Chemotherapy/Radiation Therapy With ZD1839 (IRESSA), 5-FU, Hydroxyurea, and Twice-Daily Radiation, Followed by Adjuvant ZD1839 Monotherapy in Patients With Locally Advanced Head & Neck Cancer Unknown status Head and Neck Cancer NCT01185171
Selumetinib in Combination With Gefitinib in NSCLC Patients Completed Non-small Cell Lung Cancer (NSCLC) NCT02025114
An Open-label, Phase II Trial of ZD1839 (IRESSA) in Patients With Malignant Mesothelioma Completed Mesothelioma NCT00787410
Iressa as Second Line Therapy in Advanced NSCLC-Asia Completed NSCLC NCT00478049
Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib Terminated Lung Cancer|Head and Neck Cancer NCT01405846
To Evaluate the Efficacy and Safety of Gefitinib in Adjuvant Chemotherapy for Lung Adenocarcinoma Recruiting NSCLC|EGFR NCT03656393
Paclitaxel/Carboplatin (PC) Followed by Gefitinib Versus PC in Advanced Non-small Cell Lung Cancer Completed Non Small Cell Lung Cancer NCT01196234
Gefitinib and PEG-Interferon Alfa-2b in Treating Patients With Unresectable or Metastatic Kidney Cancer Terminated Kidney Cancer NCT00467077
First-line Gefitinib Versus Chemotherapy for Lung Adenocarcinoma in Never Smoker Completed Lung Cancer NCT00455936
Gefitinib and Celecoxib in Treating Patients With Refractory Non-Small Cell Lung Cancer Completed Lung Cancer NCT00068653
ZD 1839 in Treating Patients With Metastatic or Recurrent Cancer of the Head and Neck Completed Head and Neck Cancer NCT00015964
Phase I Study of Iressa and CRT/IMRT in Chinese Patients With IIIB/IV NSCLC After Failure of Platinum-Based Chemotherapy Unknown status Carcinoma, Non-Small-Cell Lung NCT00497250
Trial of ZD1839 (Iressa) and Tamoxifen in Breast Cancer Patients Terminated Breast Cancer NCT00206492
Pemetrexed (ALIMTA) and Gefitinib (IRESSA®) in Never-Smoker and Adenocarcinoma Patients With Non-Small Cell Lung Cancer Previously Treated With Platinum-Based Chemotherapy Unknown status Non-small Cell Lung Cancer NCT01066195
Oxaliplatin With or Without Gefitinib in Treating Patients With Metastatic or Locally Recurrent Colorectal Cancer Completed Colorectal Cancer NCT00026299
IRESSA™ (Gefitinib) in Breast Cancer Patients Completed Breast Cancer NCT00632723
Study of Vorinostat and Gefitinib in Relapsed/ or Refractory Patients With Advanced Non-small Cell Carcinoma (NSCLC) Unknown status Non-Small-Cell Lung Carcinoma NCT01027676
Trial of Iressa in Prostate Cancer Patients Completed Prostate Cancer NCT00265070
Gefitinib in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed Gastrinoma|Glucagonoma|Insulinoma|Metastatic Gastrointestinal Carcinoid Tumor|Pancreatic Polypeptide Tumor|Recurrent Gastrointestinal Carcinoid Tumor|Recurrent Islet Cell Carcinoma|Somatostatinoma|WDHA Syndrome NCT00075439
ZD1839 (Iressa) for Recurrent or Metastatic Squamous Cell Carcinoma of the Skin Completed Skin Cancer NCT00054691
Phase III Trial Of Docetaxel Versus Docetaxel Plus ZD1839 In Head And Neck Cancer Terminated Recurrent Head and Neck Cancer|Metastatic Head and Neck Cancer NCT00088907
SELINE: Second-Line Iressa Phase IV Study in NSCLC Patients Completed Non Small Cell Lung Carcinoma NCT00608868
Clinical Trial of YH25448(Lazertinib) as the First-line Treatment in Patients With EGFR Mutation Positive Locally Advanced or Metastatic NSCLC (LASER301) Recruiting Non-Small Cell Lung Cancer NCT04248829
Ph II Early BC Pre-Surgical Biologic Study Completed Breast Cancer NCT00637026
Adjuvant Therapy of Gefitinib (Iressa, ZD1839) in Patients With Resectable Hepatocellular Carcinoma Active, not recruiting Liver Cancer NCT00282100
A Safety and Efficacy Study of INC280 and Gefitinib in Patients With EGFR Mutated, c-MET-amplified NSCLC Who Have Progressed After EGFRi Treatment Active, not recruiting Non-small Cell Lung Cancer NCT01610336
Phase II Metastatic ER+/PgR+ Nolvadex +/- Iressa Study Completed Breast Neoplasms NCT00229697
Docetaxel in Combination With Iressa in Previously Treated Patients With Pancreatic Cancer Completed Metastatic Pancreatic Carcinoma NCT00137761
Everolimus and Gefitinib in Treating Patients With Progressive Glioblastoma Multiforme or Progressive Metastatic Prostate Cancer Completed Brain and Central Nervous System Tumors|Prostate Cancer NCT00085566
Gefitinib Followed By Surgery in Treating Women With Ductal Carcinoma In Situ of the Breast Terminated Breast Cancer NCT00082667
Phase II Study of Docetaxel + ZD1839 in Elderly Patients With Non-Small Cell Lung Cancer Completed Non-Small Cell Lung Cancer NCT00231465
Assess the Efficacy of Whole Brain Radiation Therapy in Lung Cancer Patients With Brain Metastasis Terminated EGFR-mutated Lung Adenocarcinoma|Brain Metastasis NCT01363557
Gefitinib for EGFR Sensitive Mutation Postoperative Stage Ib NSCLC Patients Terminated NSCLC NCT02526537
Induction Therapy With Intercalated Tyrosine Kinase Inhibitor (TKI) and Chemotherapy in NSCLC With Activating Epidermal Growth Factor Receptor (EGFR) Mutation in Stages II-IIIB Terminated Non-squamous Non-small Cell Lung Cancer Stage II|Non-squamous Non-small Cell Lung Cancer Stage IIIA|Non-squamous Non-small Cell Lung Cancer Stage IIIB|Activating EGFR Mutation|NSCLC NCT02326285
Gefitinib in Treating Patients With Stage IB, II, or IIIA Non-small Cell Lung Cancer That Was Completely Removed by Surgery Completed Adenocarcinoma of the Lung|Adenosquamous Cell Lung Cancer|Bronchoalveolar Cell Lung Cancer|Large Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IB Non-small Cell Lung Cancer|Stage IIA Non-small Cell Lung Cancer|Stage IIB Non-small Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer NCT00049543
EGFR Mutation Positive NSCLC Patients With Gefitinib and Thalidomide Recruiting NSCLC Stage IV|Chemotherapy Effect NCT03341494
Iressa Re-challenge in Advanced NSCLC EGFR-mutated Patients Terminated Lung Cancer NCT02025218
Intercalated Administration of PamCis With Gefitinib or Placebo as First Line Lung Adenocarcinoma in Never Smokers Unknown status Non Small Cell Lung Cancer|Adenocarcinoma NCT01502202
Cediranib Maleate With or Without Gefitinib in Treating Patients With Recurrent or Progressive Glioblastoma Terminated Glioblastoma NCT01310855
Gefitinib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma NCT00014170
Gefitinib and Capecitabine in Treating Patients With Advanced Solid Tumors Completed Unspecified Adult Solid Tumor, Protocol Specific NCT00039390
Iressa/Docetaxel in Non-Small-Cell Lung Cancer Withdrawn Non-small Cell Lung Cancer NCT00048087
Effect of Iressa With/Without Concurrent Chemoradiotherapy on Tumor Gene Expression Profiles in Patients With Advanced Non-Nasopharyngeal Head and Neck Carcinoma Completed Head and Neck Cancer NCT00228488
Open Label Trial to Assess Iressa in Prostate Cancer Patients Completed Prostate Cancer NCT00635856
Therapy With Docetaxel and ZD1839 for Patients Who Have Advanced Breast Cancer Completed Breast Neoplasms NCT00052169
Gefitinib in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer Completed Head and Neck Cancer NCT00024089
Gefitinib in Combination With Chemoradiation in Resectable Gastric Cancer Terminated Subjects With Resectable Local or Locally Advanced, Non-Metastatic (T2-T4, N0-N3, M0; Stages II and III) and Histologically-Confirmed Intestinal GC NCT00237900
Gefitinib Plus Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Bladder Cancer Completed Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter|Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter NCT00041106
Gefitinib in Treating Patients With Esophageal Cancer That is Progressing After Chemotherapy Completed Adenocarcinoma of the Gastroesophageal Junction|Esophageal Cancer NCT01243398
UFUR (Tegafur/Uracil) Plus Iressa in Non-small-cell Lung Cancer Completed Non-Small-Cell Lung Cancer NCT01037998
A Phase I Study of Cetuximab in Combination With Gefitinib in Patients With Advanced/Metastatic Non-Small Cell Lung Cancer Completed Non-Small-Cell Lung Carcinoma NCT00162318
Erlotinib Re-Challenge for Recurrent EGFR-mutant Lung Cancer in Patients Who Previously Received Adjuvant Erlotinib or Gefitinib Terminated Lung Cancer NCT01189435
Open-Label Extension of Other SZ1839 (Iressa) Trials Completed Cancer NCT00635973
Safety and Efficacy Study of Icotinb in Non-small Cell Lung Cancer (NSCLC) Patients Completed Non-small Cell Lung Cancer NCT01040780
S0031, ZD 1839 in Treating Patients With Advanced Cancer of the Urinary Tract Completed Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer NCT00014144
Iressa Expanded Access Program (EAP) Completed Carcinoma|Non-small-cell Lung|Metastases|Neoplasm NCT00034879
Tepotinib With Gefitinib in Subjects With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Active, not recruiting Non-small Cell Lung Cancer NCT01982955
Phase II Trial of Preoperative Therapy With Gefitinib and Chemotherapy in Patients With ERneg Breast Cancer Completed Breast Cancer NCT00239343
Gefitinib Long-term Survivor Study Completed EGFR Mutation Positive Advanced Non-small-cell Lung Cancer NCT02932345
Gefitinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III or Stage IV Head and Neck Cancer Terminated Stage III Squamous Cell Carcinoma of the Hypopharynx|Stage III Squamous Cell Carcinoma of the Larynx|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Larynx|Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IV Squamous Cell Carcinoma of the Oropharynx NCT00033449
Head and Neck Phase III Iressa Versus Methotrexate Refractory: Iressa Versus Methotrexate (IMEX) Completed Squamous Cell Carcinoma of the Head and Neck NCT00206219
A Study to Predict Gefitinib' s Efficacy for Lung Cancer by Plasma Free Nucleic Acids EGFR Gene Mutation Test Unknown status Lung Adenocarcinoma NCT02738684
Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal Cancer Terminated Adenocarcinoma of the Colon|Adenocarcinoma of the Rectum|Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum|Recurrent Colon Cancer|Recurrent Rectal Cancer|Signet Ring Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Rectum|Stage IV Colon Cancer|Stage IV Rectal Cancer NCT00052585
Paclitaxel, Cisplatin, Gefitinib, and Radiation Therapy Followed by Surgery and Gefitinib in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction That Can Be Removed By Surgery Terminated Esophageal Cancer NCT00493025
IRESSA™ (Gefitinib) With Cisplatin Plus Radiotherapy for the Treatment of Previously Untreated Unresected Late Stage III/IV Non-Metastatic Head and Neck Squamous Cell Carcinoma Completed Neoplasms, Squamous Cell NCT00229723
A Study of Alimta/Cisplatin/Gefitinib for Asian Non-smoking Participants With Non Small Cell Lung Cancer Completed Non Small Cell Lung Cancer NCT01017874
A Study of IRESSA Treatment Beyond Progression in Addition to Chemotherapy Versus Chemotherapy Alone Completed Non-Small Cell Lung Cancer NCT01544179
Iressa vs Best Supportive Care - 2nd/3rd Line Survival Study Completed NSCLC NCT00242801
BCG With or Without Gefitinib in Treating Patients With High-Risk Bladder Cancer Terminated Bladder Cancer NCT00352079
Gefitinib With or Without Carboplatin and Paclitaxel in Treating Older Patients With Unresectable or Metastatic Non-Small Cell Lung Cancer Completed Lung Cancer NCT00062062
Prophylactic Cranial Irradiation in Erlotinib/Gefitinib-responders With Non-small Cell Lung Cancer (NSCLC) (RT1001) Unknown status Non-small Cell Lung Cancer NCT01158170
Cisplatin, Fluorouracil, Iressa, and Radiation Therapy Patients With Locally Advanced Head and Neck Cancer Completed Head and Neck Cancer NCT00352105
Gefitinib and PEG-Interferon Alfa-2a in Treating Patients With Unresectable or Metastatic Skin Cancer Unknown status Non-melanomatous Skin Cancer NCT00423397
Phase II Gemcitabine + Cisplatin +/- Iressa Bladder CCT Completed Bladder Cancer NCT00246974
Post-operative Radiotherapy With Cisplatin Alone or in Combination With Iressa in Upper Aerodigestive Tract Carcinomas Terminated Head and Neck Cancer NCT00169221
Combination Chemotherapy, Radiation Therapy, and Gefitinib in Treating Patients With Stage III Non-Small Cell Lung Cancer Completed Adenocarcinoma of the Lung|Adenosquamous Cell Lung Cancer|Bronchoalveolar Cell Lung Cancer|Large Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer NCT00040794
Anastrozole With or Without Gefitinib in Treating Postmenopausal Women With Metastatic or Locally Recurrent Breast Cancer Completed Breast Cancer NCT00066378
Genius Study Study to Compare Efficacy and Safety of Gefitinib/ Pemetrexed With Pemetrexed Alone as Maintenance Therapy in Patients With Stage IV EGFR Mutation Negative or T790M Single Mutation Who Respond to Pemetrexed/ Platinum as First-line Therapy Unknown status NSCLC NCT01579630
Study of Gefitinib Compared With Pemetrexed/Cisplatin in Advanced Non-Small Cell Lung Cancer Patients Unknown status Toxicity|Non-small Cell Lung Cancer NCT01192243
ZD1839 With Hypofractionated Radiation Therapy With an Immobilization Device for Advanced Non-Small Cell Lung Cancer Completed Non-Small Cell Lung Carcinoma (NSCLC) NCT00328562
Gefitinib in the Treatment of the First Relapse of Prostate Cancer Beyond Prostatectomy or Radiotherapy Completed Prostate Cancer NCT00241475
Anastrozole and ZD1839 Compared With Fulvestrant and ZD1839 in Postmenopausal Women w/ Metastatic Breast Cancer Completed Estrogen Receptor-positive Breast Cancer|Progesterone Receptor-positive Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer NCT00057941
Phase II Iressa Versus Vinorelbine (INVITE) Completed Non-Small-Cell Lung Carcinoma NCT00256711
Iressa as a First-Line Treatment in Chemonaive Patients With Inoperable Non-Small Cell Lung Cancer Completed Non-Small Cell Lung Cancer NCT00173875
Gefitinib After Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer Terminated Lung Cancer NCT00091156
Radiation Therapy Combined With Either Gefitinib or Temozolomide in Pats With NSCLC and Brain Metastases Completed Lung Cancer|Metastatic Cancer NCT00238251
A Phase II Exploratory, Multicentre, Open-label, Non-comparative Study of ZD1839 (Iressa) and Radiotherapy in the Treatment of Patients With Glioblastoma Multiforme Completed Glioblastoma NCT00238797
Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors Completed Brain and Central Nervous System Tumors NCT00025675
Gefitinib in Treating Patients With Recurrent Metastatic Colorectal Cancer Completed Colorectal Cancer NCT00025350
Gefitinib, Trastuzumab, and Docetaxel in Treating Patients With Metastatic Breast Cancer Completed Breast Cancer NCT00086957
Gefitinib in Treating Patients With Locally Advanced or Metastatic Synovial Sarcoma Completed Sarcoma NCT00052754
A Study of ZD1839 Effects on Cell Proliferation in Breast Cancer Withdrawn Breast Cancer NCT00252811
Iressa Versus Docetaxel (Taxotere) Completed Non-Small-Cell Lung Carcinoma NCT00076388
Gefitinib in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer or Primary Peritoneal Cancer Completed Ovarian Cancer|Primary Peritoneal Cavity Cancer NCT00023699
Phase I Study of AZD2171 co-Administered With Fixed Multiple Oral Doses of ZD1839 in Patients With Advanced Cancer Completed Advanced Tumor NCT00502060
A Study of IRESSA in Relapsed and Refractory Small Cell Lung Cancer Completed Small Cell Lung Cancer NCT00298688
A Trial to Evaluate the Combination of Iressa & Faslodex® in Patients With Advanced or Metastatic Breast Cancer Completed Breast Cancer NCT00234403
A Study to Evaluate Safety and Efficacy of HS-10296 as First-Line Treatment in Patients Recruiting Non Small Cell Lung Cancer NCT03849768
An Expanded Access Programme With Iressa for Patients With Non-Small-Cell Lung Cancer and Cancer of the Head and Neck Approved for marketing Non Small Cell Lung Cancer|Cancer of the Head and Neck NCT00684385
Gefitinib in Treating Patients With Stage IIIA Non-Small Cell Lung Cancer Unknown status Lung Cancer NCT00616499
Iressa and Taxotere Study in Patients With Metastatic Urothelial Cancer Terminated Bladder Cancer NCT00479089
A Phase I Study of ZD1839 and Palliative Thoracic Radiotherapy in Patients With Non-small-cell Lung Cancer Completed Non-small-cell Lung Cancer NCT00255489
ZD1839 and Oral Irinotecan in Treating Young Patients With Refractory Solid Tumors Completed Glioblastoma|Rhabdomyosarcomas|Neuroblastoma|Osteosarcoma NCT00132158
Iressa 2nd Line Phase III Study in Japan Completed Non-Small Cell Lung Cancer NCT00252707
Phase II Trial of ZD1839 (Iressa) in Patients With Nonresectable Adrenocortical Carcinoma (ACC) Completed Nonresectable Adrenocortical Carcinoma NCT00215202
Gefitinib as First-Line Therapy Followed by Gemcitabine and Cisplatin in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Completed Lung Cancer NCT00217698
Iressa in the Treatment of Brain Metastases From Non Small Cell Lung Cancer Terminated Brain Neoplasms|Non Small Cell Lung Cancer NCT00234442
Gefitinib With or Without Tamoxifen in Treating Patients With Tamoxifen-Resistant Metastatic Breast Cancer Completed Breast Cancer NCT00080743
Second-Line Irinotecan or Gefitinib in Docetaxel Pretreated NSCLC Unknown status Non-Small Cell Lung Cancer NCT00319800
ZD1839 (Iressa™) In Combination With Docetaxel As First-Line Treatment In Patients With Metastatic Breast Cancer Completed Breast Cancer NCT00247481
Observations From Long Term Responders in the Gefitinib (Iressa) Expanded Access Program (EAP) Completed Non-Small Cell Lung Cancer NCT01103089
Study of TLK286 (Telcyta) vs. Gefitinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer Completed Non Small Cell Lung Carcinoma NCT00080340
Pre- and Postoperative Use of ZD1839 (Iressa) in Recurrent Glioblastoma, Including Translational Research Completed Recurrent Glioblastoma NCT00250887
Gefitinib, Docetaxel, and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer Completed Lung Cancer NCT00310154
A Randomized Phase III Trial of Chemotherapy Alone Versus Chemotherapy Followed by Gefitinib in Stage IIIB/IV Non-Small Cell Lung Cancer Completed Lung Cancer NCT00144066
Gefitinib in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer That Can Be Removed By Surgery Terminated Esophageal Cancer NCT00258297
Gefitinib in Treating Patients With Metastatic Breast Cancer That Has Progressed After Antiestrogen and Nonsteroidal Aromatase Inhibitor Therapy Completed Breast Cancer NCT00066339
Safety Study to Explore Combination of Gefitinib (ZD1839, Iressa) and Radiotherapy in Non-Metastatic Prostate Cancer Completed Non-Metastatic Prostate Cancer NCT00239291
Gefitinib and Docetaxel in Treating Patients With Advanced Solid Tumors Completed Unspecified Adult Solid Tumor, Protocol Specific NCT00084786
A Phase II Study of Iressa in Patients With Chemo Refractory Germ Cell Tumors Expressing EGFR Terminated Refractory Germ Cell Tumors Expressing EGRF NCT00198159
Management of Advanced Non-Small Cell Lung Cancer (NSCLC) and Clinical Outcomes in Patients Who Received Gefitinib in Thailand Completed Lung Cancer NCT01130961
Gefitinib Plus Temozolomide in Treating Patients With Malignant Primary Glioma Completed Brain and Central Nervous System Tumors NCT00027625
Treatment of Lung Adenocarcinoma With Bronchioloalveolar Feature Completed Pneumonic-type Adenocarcinoma (P-ADC)|Lung Adenocarcinoma With Bronchiolo-alveolar Feature NCT00198380
Phase II Iressa & Carbo/Gem in NSCLC Completed Carcinoma, Non-Small-Cell Lung NCT00264498
Iressa (ZD1839) Plus Anastrozole (Arimidex) in Patients With Ovarian Cancer Completed Ovarian Cancer|Peritoneal Carcinoma|Tubal Carcinoma NCT00181688
Gefitinib and Sirolimus in Treating Patients With Recurrent or Refractory Stage IIIB or Stage IV Non-Small Cell Lung Cancer Withdrawn Lung Cancer NCT00098462
The IRESSA Novel Head and Neck Chemotherapy Evaluation Study Completed Squamous Cell Cancer|Cancer of Head and Neck NCT00255476
Trial of BMS-690514 in Non-Small Cell Lung Cancer Subjects Who Have Been Treated With Gefitinib or Erlotinib and Are Genotypically EGFR Mutation Positive or Who Have Had a Prior Response Completed Non-Small-Cell Lung Carcinoma NCT01167244
ZD 1839 in Treating Patients With Metastatic Kidney Cancer Completed Kidney Cancer NCT00012337
Gefitinib, Paclitaxel, and Radiation Therapy in Treating Patients With Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck Completed Head and Neck Cancer NCT00083057
ZD 1839 in Treating Patients With Stage IV or Recurrent Kidney Cancer Completed Kidney Cancer NCT00014183
Gefitinib in Treating Patients With Cervical Cancer Completed Cervical Cancer|Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer NCT00049556
Neoadjuvant Chemoradiotherapy With or Without Gefitinib in Treating Patients With Stage IIIA or Stage IIIB Non-Small Cell Lung Cancer Completed Lung Cancer NCT00062270
ZD 1839 in Treating Patients With Glioblastoma Multiforme in First Relapse Completed Brain and Central Nervous System Tumors NCT00016991
Combination Chemotherapy and Radiation Therapy With or Without Gefitinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery Completed Adenocarcinoma of the Lung|Bronchoalveolar Cell Lung Cancer|Large Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer NCT00020709
ZD 1839 in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer Completed Colorectal Cancer NCT00030524
ZD 1839 in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy Completed Prostate Cancer NCT00025116
A Study of Serum Protein Profiling in Patients With Non-Small Cell Lung Cancer Treated With Gefitinib or Erlotinib Completed Non Small Cell Lung Cancer NCT00717847
Cisplatin and ZD1839 + Re-Irradiation in Recurrent Squamous Cell Cancer of the Head and Neck Completed Head and Neck Cancer|Carcinoma, Squamous Cell NCT00185835
Paclitaxel, Carboplatin, and Gefitinib in Treating Patients With Advanced Non-Small Cell Lung Cancer Unknown status Lung Cancer NCT01024712
Chemotherapy Plus Gefitinib Followed by Chemotherapy, Radiation Therapy, and Gefitinib For Head and Neck Cancer Completed Head and Neck Cancer NCT00193284
Osimertinib Treatment on EGFR T790M Plasma Positive NSCLC Patients (APPLE) Recruiting NSCLC NCT02856893
Safety and Effectiveness Study of Docetaxel and ZD1839 Followed by Removal of the Prostate to Treat Prostate Cancer Completed Prostate Cancer NCT00242918
Safety Trial of IRESSA, Cisplatin and Radiation Therapy for Patients With Head and Neck Cancer Terminated Head and Neck Cancer NCT00195078
Gefitinib (Iressa) in Combo With Chemoradiation in Patients With Locally Advanced Head & Neck Cancer Completed Head and Neck Neoplasms NCT00239304
IRESSA™ In Combo With Xeloda™ in Advanced Colorectal Cancer Patients After 1st-Line Chemo Failure Completed Colorectal Cancer NCT00242788
Iressa vs Placebo as Maintenance Therapy in Locally Advanced NSCLC Terminated Non Small Cell Lung Carcinoma NCT00234468
Immune-Modulated Study of Selected Small Molecules (Gefitinib, AZD9291, or Selumetinib + Docetaxel) or a 1st Immune-Mediated Therapy (IMT; Tremelimumab) With a Sequential Switch to a 2nd IMT (MEDI4736) in Patients With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer Completed Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (Stage IIIB-IV) NCT02179671
First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System Metastases Recruiting Non-small Cell Lung Cancer|EGFR Gene Mutation|Brain Metastases NCT03653546
Chemotherapy for Patients With Non-Small Cell Lung Cancer Who Are Non-Smokers Completed Non-small Cell Lung Cancer NCT00409006
Cisplatin and Irinotecan Chemotherapy, Followed by ZD 1839 (Iressa) in Patients With Esophageal or Gastric Carcinomas Completed Esophageal Cancer|Gastric Cancer NCT00215995
Phase II Neoadjuvant ER+/PgR + Arimidex +/- Iressa Study Completed Breast Cancer NCT00255463
Maintenance ZD1839 (IRESSA®) Following Completion of Front Line, Platinum-Based, Double Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer Withdrawn Non-Small-Cell Lung Carcinoma NCT00090675
Gefitinib and Radiation Therapy in Treating Patients With Inoperable Stage I or Stage II Non-Small Cell Lung Cancer Withdrawn Non-small Cell Lung Cancer NCT00268255
A Phase 2 Study of Tomudex & Iressa as Second Line Chemotherapy in Subjects With Colorectal Carcinoma Completed Colorectal Cancer NCT00234429
Dasatinib in Treating Patients With Advanced Lung Cancer That Is No Longer Responding to Erlotinib or Gefitinib Completed Lung Cancer NCT00570401
Study of ZD1839 Combined With Irinotecan and Vincristine in Pediatric Patients With Refractory Solid Tumors Completed Solid Tumors NCT00186979
IRESSA in Combination With Cisplatin & Radiotherapy in Patients With Advanced Head & Neck Carcinoma Completed Cancer of Head and Neck NCT00242749
Capecitabine, Oxaliplatin, and Gefitinib in Treating Patients With Metastatic Colorectal Cancer Terminated Colorectal Cancer NCT00087334
Gemcitabine, Cisplatin, and Gefitinib in Treating Patients Who Are Undergoing Surgery for Stage III Non-Small Cell Lung Cancer Completed Lung Cancer NCT00103051
ZD1839 (Iressa™) and Concurrent Chemo-Radiation in Patients With Locally Advanced Non Small Cell Lung Cancer Completed Non Small Cell Lung Carcinoma NCT00252798
Increased Dose of Icotinib in Advanced None Small Cell Lung Cancer Patients After Routine Gefitinib Therapy Suspended Non-small Cell Lung Cancer NCT01720901
Iressa in Poor Performance Status Patients With Previously Untreated Advanced Non-Small Cell Lung Cancer Completed Lung Cancer NCT00193336
Calcitriol and Gefitinib With or Without Dexamethasone in Treating Patients With Advanced Solid Tumors Completed Unspecified Adult Solid Tumor, Protocol Specific NCT00084708
IRESSA Combined With Radiotherapy & Gemcitabine as First-Line Treatment in Locally Advanced Pancreatic Cancer Completed Pancreatic Cancer NCT00234416
Iressa and Radiotherapy in the Treatment of the Locally Advanced Inoperable Squamous Cell Carcinoma of the Head and Neck Withdrawn Head and Neck Cancer|Carcinoma, Squamous Cell NCT00233636
Anastrozole and ZD 1839 in Treating Postmenopausal Women With Metastatic Breast Cancer Completed Breast Cancer NCT00049062
Gilotrif (Afatinib) in Advanced Non-Small Cell Lung Cancer Patients Pre-treated With Erlotinib or Gefitinib Completed Non-small Cell Lung Cancer NCT02747953
A Retrospective Pharmacogenomics Research of EGFR-TKIs,Gefitinib and Erlotinib, in NSCLC Patients Treatment Recruiting Non-small Cell Lung Cancer (NSCLC)|EGFR-TKI Resistant Mutation|EGFR-TKI Sensitizing Mutation|Germline Mutations|Somatic Mutation NCT01994057
Combination Weekly Taxotere™ With Iressa™ /Placebo in Metastatic Breast Cancer Completed Metastatic Breast Cancer NCT00319618
Gefitinib, Cisplatin, Irinotecan, and Radiation Therapy Before Surgery in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By Surgery Terminated Esophageal Cancer NCT00290719
Oxaliplatin, Gefitinib, and Radiation Therapy in Treating Patients With Locally Advanced or Metastatic Esophageal Cancer Terminated Esophageal Cancer NCT00093652
Combination Casodex® and Iressa™ in Locally Advanced Prostate Cancer Completed Locally Advanced Prostate Cancer NCT00319787
An Open Label Study of BIBW 2992/Afatinib in Advanced Non-Small Cell Lung Cancer Patients Pre-treated With Erlotinib or Gefitinib Unknown status NSCLC NCT01932229
Gefitinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Colorectal Cancer Completed Colorectal Cancer NCT00025142
Radiotherapy,Chemotherapy,Before and After Surgery in Advanced Esophageal or Gastroesophageal Junction Cancer Completed Esophageal Cancer NCT00258323
Study of XL647 in Subjects With NSCLC Who Have Progressed After Responding to Treatment With Gefitinib or Erlotinib Completed Carcinoma, Non-Small-Cell Lung NCT00522145
Tetracycline in Preventing Skin Rash in Patients Who Are Receiving Drugs Such as Gefitinib and Cetuximab for Cancer Completed Unspecified Adult Solid Tumor, Protocol Specific NCT00091247
ZD 1839 Plus Combination Chemotherapy in Treating Patients With Locally Advanced, Locally Recurrent, or Metastatic Colorectal Cancer Completed Colorectal Cancer NCT00026364
BIBW 2992 and BSC Versus Placebo and BSC in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib (LUX-LUNG 1) Completed Carcinoma, Non-Small-Cell Lung NCT00656136
A Phase I/II Study of Bexarotene in Combination With ZD1839 (IRESSA®) in the Treatment of Non-Small Cell Lung Cancer Completed Lung Cancer NCT00238628
ZD 1839 Plus Combination Chemotherapy in Treating Patients With Non-Small Cell Lung Cancer Unknown status Lung Cancer NCT00006048
PharmacoEconomic Assessment IRESSA® in the Treatment of Non-Small-Cell Lung Cancer (NSCLC) Unknown status Non-Small Cell Lung Cancer NCT00173524
A Study on the Long Term Survivals in an Expand Access Program (EAP) of Iressa Completed Non-small Cell Lung Cancer NCT01000740
Pemetrexed Disodium and Carboplatin or Cisplatin With or Without Erlotinib Hydrochloride in Treating Patient With Stage IV Non-Small Cell Lung Cancer Resistant to First-Line Therapy With Erlotinib Hydrochloride or Gefitinib Withdrawn Recurrent Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer NCT01928160
ZD 1839 Plus Chemotherapy in Treating Patients With Non-Small Cell Lung Cancer Unknown status Lung Cancer NCT00006049
AZD9291 Versus Gefitinib or Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Active, not recruiting Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non Small Cell Lung Cancer NCT02296125
Phase II Iressa + Irradiation Followed by Chemo in NSCLC Completed Non-Small Cell Lung Cancer NCT00333294
This Study is to Compare the Efficacy of ZD6474 and ZD1839 in Subjects With NSCLC. Completed Carcinoma, Non-Small-Cell Lung NCT00059722
A Phase II Study of ZD1839 and Tamoxifen in Patients With Epithelial Ovarian Carcinoma, Cancer of the Fallopian Tube or the Peritoneum Refractory to Platinum- and Taxane-based Therapy Completed Ovarian Cancer|Cancer of the Fallopian Tube|Peritoneal Cancer NCT00189358
β-elemene Combine With EGFR-TKI for Advanced EGFR-TKI-resistant NSCLC Unknown status Non Small Cell Lung Cancer NCT03123484
ZD1839 (IRESSA™) in Combination With Docetaxel & Cisplatin in Subjects With Metastatic Head & Neck Cancer Completed Head and Neck Cancer NCT00242762
A Study of BPI-7711 Capsule in Non-small Cell Lung Cancer Patients Recruiting NSCLC NCT03866499
Irinotecan, 5-Fluorouracil and Leucovorin With or Without Iressa in the Treatment of Metastatic Colorectal Cancer Withdrawn Metastatic Colorectal Cancer NCT00233623
Dynamic Changes of Circulating Tumor DNA in Late Stage NSCLC Patients Unknown status Carcinoma, Non-Small-Cell Lung|Bronchial Neoplasms|Carcinoma, Bronchogenic|Lung Diseases|Lung Neoplasms NCT02804100
Iressa Case Control Study in Japan Completed Non-small Cell Lung Cancer NCT00252759
Descriptive Pharmacoepidemiological Study of Patients Treated With Iressa Completed Lung Cancer NCT01448187
LUX-Lung 4: BIBW 2992 (Afatinib) Phase I Trial in Advanced Non Small Cell Lung Cancer Patients & Phase II Trial in Non Small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib Completed Carcinoma, Non-Small-Cell Lung NCT00711594
Abivertinib Maleate Versus Geifitinib in Patients With Advanced Non-small Cell Lung Cancer With Sensitive EGFR Mutation Not yet recruiting Advanced Non-small Cell Lung Cancer NCT03856697
Study to Allow Patients Previously Participating in a Novartis Sponsored Trial to Continue Receiving INC280 Treatment as Single Agent or in Combination With Other Treatments. Active, not recruiting Advanced Solid Tumors Which Are cMET-dependent NCT03040973
Exploratory Study of Drug Sensitivity Prediction Software (IRCR-DReSS) With Patient-derived Tumor Cells of Metastatic Gastric Cancer Recruiting Stomach Neoplasms NCT03170180
LUX-Lung 5: Afatinib Plus Weekly Paclitaxel Versus Investigator's Choice of Single Agent Chemotherapy Following Afatinib Monotherapy in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib Completed Carcinoma, Non-Small-Cell Lung NCT01085136
Trial of Continuous Once Daily Oral Treatment Using BIBW 2992 (Afatinib) Plus Sirolimus (Rapamune®) in Patients With Non-small Cell Lung Cancer Harbouring an EGFR Mutation and/or Disease Progression Following Prior Erlotinib or Gefitinib Completed Carcinoma, Non-Small-Cell Lung NCT00993499
Stereotactic Body Radiation Therapy (SBRT) in Newly Diagnosed Advanced Staged Lung Adenocarcinoma (Sindas) Recruiting Stage IV EGFR Mutated Non-Small Cell Lung Cancer NCT02893332
Anticancer Activity of Nicotinamide on Lung Cancer Active, not recruiting Non-Small-Cell Lung Carcinoma NCT02416739
EGFR-TKIs Combine With Anlotinib as First-line Treatment for Patients With Advanced EGFR Mutation-positive NSCLC Recruiting EGFR Gene Mutation NCT03720873
EGFR-TKI With/Without Chemotherapy in NSCLC Patients With Both EGFR Mutation and BIM Deletion Polymorphism Unknown status Nonsmall Cell Lung Cancer|EGFR Gene Mutation NCT03002844
A Study of LY2875358 in Japanese Participants With Advanced Cancer Completed Solid Tumors|Lymphoma|Carcinoma, Non-Small-Cell Lung NCT01602289
Customized Neoadjuvant Versus Standard Chemotherapy in NSCL Patients With Resectable Stage IIIA (N2)Disease Unknown status Non Small Cell Lung Cancer NCT01784549
Apatinib Combine With EGFR-TKI for Advanced EGFR-TKI-resistant Non-Small Cell Lung Cancer Unknown status Nonsmall Cell Lung Cancer NCT03050411
Gemcitabine/Irinotecan/ZD1839 vs Paclitaxel/Carboplatin/Etoposide/ZD1839 in Carcinoma of Unknown Primary Site Completed Neoplasms, Unknown Primary NCT00193596
A Study of Hypofractionated Radiotherapy for Limited Metastatic NSCLC Harboring Sensitizing EGFR Mutations After First Line TKI Therapy Not yet recruiting Lung Adenocarcinoma|EGFR Positive Non-small Cell Lung Cancer NCT02788058
A Open-label Prospective Cohort Trial of Curcumin Plus Tyrosine Kinase Inhibitors (TKI) for EGFR -Mutant Advanced NSCLC Unknown status Lung Cancer NCT02321293
Study of Chemotherapy Sequenced by or Combined With EGFR-TKIs for NSCLC Patients Failed to EGFR-TKIs Therapy Unknown status Non Small Cell Lung Cancer NCT01746277
Can Epidermal Growth Factor Receptor Improve the Postoperative Survivorship for Inoperable Non-small Cell Lung Cancer With Spinal Metastasis ? Completed Is Targeted Therapy Increasing Survival Inoperable Nonsmall Cell Lung Cancer With Spinal Metastasis ? NCT02740894
Induction Chemotherapy Using Paclitaxel, Carboplatin, CPT-11 With Pegfilgrastim Completed Non Small Cell Lung Cancer NCT00280787
Anlotinib Hydrochloride Combined With EGFR TKIs in Advanced Non-small Cell Lung Cancer Not yet recruiting Non-Small-Cell Lung NCT03766490
Trial of BIBW 2992 (Afatinib) + Cetuximab in Non-Small Cell Lung Cancer Completed Carcinoma, Non-Small-Cell Lung NCT01090011
A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Previously Untreated Participants With EGFR Mutation-Positive Metastatic NSCLC (RELAY) Active, not recruiting Metastatic Non-Small Cell Lung Cancer NCT02411448
Intercalated Combination of Chemotherapy and Tyrosine Kinase Inhibitors as First-line Treatment for Patients With Non-Small-Cell Lung Cancer Unknown status Non-Small-Cell Lung Cancer NCT02031601
Afatinib Plus Nimotuzumb for NSCLC Unknown status NSCLC NCT01861223
EGFR-TKI Concurrent With/Without WBRT in Brain Metastasis From NSCLC Recruiting Non-Small Cell Lung Cancer NCT02714010
Radiation Therapy to the Brain or Observation in Preventing Brain Metastases in Patients With Advanced Non-Small Cell Lung Cancer Unknown status Lung Cancer NCT00955695
Efficacy Study of Chinese Medicine Plus EGFR-TKI Versus EGFR-TKI in Advanced Pulmonary Adenocarcinoma Unknown status Cancer NCT01745302
Therapy for Children With Neuroblastoma Completed Neuroblastoma NCT00135135
Clinical Study of Chinese Medicine Plus Targeted Therapy Maintenance in Advanced Pulmonary Adenocarcinoma Completed Cancer NCT02889692
Combination Chemotherapy in Treating Patients With Advanced Non-Small Cell Lung Cancer Completed Lung Cancer NCT00005806
Anlotinib Hydrochloride Combined With EGFR-Tyrosine Kinase Inhibitor (TKI) in Treating Advanced NSCLC Patients With Acquired Resistance to EGFR-TKI Not yet recruiting NSCLC NCT04007835
Hypofractionated Brain Radiation In EGFR Mutated Adenocarcinoma Cranial Disease (Hybrid) Recruiting Stage IV EGFR Mutated NSCL With Brain Metastases NCT02882984
Evaluation of EGFR TKI Resistance Mechanism Using Plasma DNA Analysis Unknown status EGFR Mutation Positive Non-small Cell Lung Cancer NCT01776684
Radiotherapy Combined With Thymosin for Metastatic NSCLC Patients Who Showed Stable Disease After First Line TKI Therapy Recruiting Lung Adenocarcinoma NCT02787447
Apatinib in the Treatment of Patients With EGFR T790M-Negative NSCLC Not yet recruiting Lung Diseases|Neoplasms|Respiratory Tract Diseases|Thoracic Neoplasms|Non-Small-Cell Lung NCT03389256
Study of EGF816 in Combination With Selected Targeted Agents in EGFR-mutant NSCLC Recruiting EGFR-mutant Non-small Cell Lung Cancer NCT03333343
A Study Of Combined C- MET Inhibitor And PAN-HER Inhibitor (PF-02341066 And PF-00299804) In Patients With Non- Small Cell Lung Cancer Completed Non Small Cell Lung Cancer NCT01121575
Lung Cancer in Women Treated With Anti-oestrogens anD Inhibitors of EGFR Active, not recruiting Stage IV Lung Cancer NCT01556191
Randomized Phase 2 Study of 3 Therapeutic Modalities in PS 2/3 Patients With NSCLC Stage IIIB/IV Completed Carcinoma, Non-Small-Cell Lung NCT00198393
Retreatment With Epidermal Growth Factor Receptor(EGFR) Tyrosine Kinase Inhibitor in EGFR Mutation Positive Patients Recruiting EGFR Positive Non-small Cell Lung Cancer NCT03382795
Local Non-salvage Radiotherapy for Synchronous Oligometastatic Non-small-cell Lung Cancer. Recruiting Stage IV Non-small Cell Lung Cancer NCT03119519
Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD) Recruiting Non-Small Cell Lung Cancer NCT03944772
Anti-angiogenesis Combine With EGFR-TKI in Advanced Non-squamous Non Small Cell Lung Cancer Unknown status Non Small Cell Lung Cancer NCT03461185
EGFR-TKI With Chemotherapy in NSCLC Patients With Both EGFR Mutation and BIM Deletion Polymorphism Unknown status Non-Small-Cell Lung Cancer NCT02859077
De Novo Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors Unknown status NSCLC NCT01697163
Studying Biomarkers in Samples From Patients With Recurrent or Metastatic Head and Neck Cancer Treated on E1302 Trial Completed Head and Neck Cancer NCT01619618
Study of Endostatin Combined With Docetaxel in the Treatment of Advanced Non-small Cell Lung Cancer Patients Unknown status Carcinoma, Non-Small-Cell Lung NCT01192230
Maintenance Targeted Therapy With or Without Stereotactic Body Radiation Therapy for Stage IV Non-small Cell Lung Cancer Recruiting Stage IV Non-small Cell Lung Cancer NCT03595644
Concordance of Key Actionable Genomic Alterations as Assessed in Tumor Tissue and Plasma in Non Small Cell Lung Cancer Terminated Non Small Cell Lung Carcinoma NCT02762877
A Pilot Study of Genomic Sequencing Guided Individualized Therapy in Gastrointestinal Cancers, GITIC Study Unknown status Gastrointestinal Cancers NCT02013089
Trial Of PF-00299804 In Patients With Advanced Refractory Lung Cancer Completed Carcinoma, Non Small Cell Lung NCT00553254
Psychometric Properties of the EORTC QLQ-LC29 Completed Lung Cancer NCT02745691
A Study of Pembrolizumab (MK-3475) in Combination With Chemotherapy or Immunotherapy in Participants With Non-small Cell Lung Cancer (MK-3475-021/KEYNOTE-021) Active, not recruiting Non-small Cell Lung Carcinoma NCT02039674
Study Evaluating the Safety Of HKI-272 (Neratinib) In Subjects With Advanced Non-Small Cell Lung Cancer Completed Carcinoma, Non-Small-Cell Lung|Lung Neoplasms NCT00266877
ARQ 197 Plus Erlotinib in Patient With Locally Advanced or Metastatic EGFR Mutation-positive Non-small-cell Lung Cancer Completed Non-small-cell Lung Cancer NCT01580735
Efficacy and Safety of Targeted Precision Therapy in Refractory Tumor With Druggable Molecular Event Recruiting Rare Tumor|Refractory Tumor NCT03239015
Development of Circulating Tumour Cell Molecular Diagnostics Using a Novel Microfluidic Device Unknown status Patients With Non-small Cell Lung Cancer NCT01193829
First Line Bio-immunotherapy With Thymosin Alpha 1 in Patients With Sensitizing EGFR Mutation Positive Non Small Cell Lung Cancer Who Are Taking Standard of Care Therapy Unknown status EGFR Mutation Positive Non Small Cell Lung Cancer NCT02906163
Evaluation of the High Dose of Icotinib in Advanced Lung Cancer Patients After Failure of Target Therapy Unknown status NSCLC NCT01963195
Conmana Combined With Thalidomide to Treat NSCLC Unknown status NSCLC NCT02778893
Tyrosine Kinase Inhibitors In Metastatic Non Small Cell Lung Cancer Unknown status Non Small Cell Lung Cancer NCT01163058
Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of AZD9291, in Patients With EGFR Positive Non-small Cell Lung Cancer. Patients Will be Chosen From Those Who Have Already Been Prescribed an EGFR TKI Medicine (Such as Iressa or Tarceva) Active, not recruiting Advanced Non Small Cell Lung Cancer|Advanced (Inoperable) Non Small Cell Lung Cancer NCT02157883
Neoadjuvant Therapy in Resectable Non-Small Cell Lung Cancer Stages IIIA Recruiting Non Small Cell Lung Cancer NCT04197076
Evaluation of the Efficacy of Low-dose Acetylsalicylic Acid on Diarrhea Induced by Anti-cancer Targeted Therapies. Withdrawn Cancer NCT02323516
The Evaluation of Lung Cancer Patient Treated With Epidermal Growth Factor Receptor Tyrosine Kinase Unknown status Non-Small-Cell Lung Cancer NCT02755337
A Phase II Trial of Afatinib in Patients With Metastatic or Recurrent Squamous Cell Carcinoma of Esophagus Active, not recruiting Squamous Cell Carcinoma of Esophagus NCT02353936
Tetracycline as a Prophylaxis for Rash in Patients With NSCLC Receiving Treatment With BIBW2992 (Afatinib) Completed Skin Rash|Lung Cancer NCT01880515
Efficacy and Safety Study of Bevacizumab Plus Chemotherapy in EGFR-TKI Resistant Non-Squamous Non-Small Cell Lung Cancer Unknown status Lung, Carcinoma NCT02139579
Clinical Pharmacokinetics of TKIs in Chinese Patients of Hepatitis B (HBV) Recruiting Non Small Cell Lung Cancer|Hepatitis B NCT03680183
Circulating Tumor DNA (ctDNA) as a Prognostic Tool in Patients With Advanced Lung Adenocarcinoma Unknown status Adenocarcinoma of Lung (Disorder) NCT03090815
Extension Study of Lapatinib Plus Herceptin With or Without Endocrine Therapy Active, not recruiting Breast Cancer NCT00999804
Erlotinib as 1st Line Treatment in NSCLC Stage IIIB/IV Completed Non Small Cell Lung Cancer NCT00615758
LUX Lung Special Access Scheme Australia Named Patient Use (NPU) Approved for marketing Carcinoma, Non-Small-Cell Lung NCT01209650
Afatinib Plus Chemotherapy Against Esophageal or Lung Squamous Cell Carcinoma Not yet recruiting Squamous Cell Carcinoma NCT03486509
Intermittent and Maintenance of Icotinib in Combination With Pemetrexed/Carboplatin Compared With Icotinib Single Drug in â…˘b/IV Non Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Mutation Not yet recruiting Lung, Carcinoma NCT03151161
Intermittent and Maintenance of Erlotinib in Combination With Pemetrexed/Carboplatin in â…˘b/IV Non Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Mutation Unknown status Lung, Carcinoma NCT02066038
Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal Metastasis Not yet recruiting Leptomeningeal Metastasis|Non-small Cell Lung Cancer|EGFR Activating Mutation NCT04148898
Registry for Patients With Acquired Resistance to Small Molecule Kinase Inhibitors in Non-Small-Cell Lung Cancer Completed Unresectable or Metastatic Non-small Cell Lung Cancer (NSCLC) NCT00579683
Phase II Clinical Study of Intermittent High Dose of Icotinib in Combination With Docetaxel to Treat Lung Cancer Unknown status Non Small Cell Lung Cancer NCT02191059
Pemetrexed and Erlotinib for Metastatic Colorectal Cancer Completed Metastatic Colorectal Cancer NCT02723578
Uncommon EGFR AZD9291 Unknown status Non Small Cell Lung Cancer NCT03424759
Combination of Cetuximab With Afatinib for Patient With EGFR Mutated Lung Cancer Active, not recruiting Non Small Cell Lung Cancer NCT02716311
PF-00299804 in Patients With Head and Neck Squamous Cell Carcinoma Completed Head Neck Cancer Squamous Cell Metastatic|Head Neck Cancer Squamous Cell Recurrent NCT01449201
MEchanisms of Resistance in EGFR Mutated Nonpretreated Advanced Lung Cancer Receiving OSimErtib Recruiting Non-small Cell Lung Cancer NCT03865511
Study Investigating the Effect of Everolimus Monotherapy in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Completed Non-small-cell Lung Carcinoma NCT00124280
Cetuximab in Patients With Lung Adenocarcinoma Receiving Erlotinib That Have Developed "Acquired Resistance" to Erlotinib Completed Lung Adenocarcinoma NCT00716456
Local Ablative Therapy for Treatment of Oligoprogressive, EGFR-Mutated, Non-Small Cell Lung Cancer After Treatment With Osimertinib Active, not recruiting Lung Adenocarcinoma|Lung Neoplasms NCT02759835
A Phase II Study of CI-1033 in Treating Patients With Metastatic (Stage IV) Breast Cancer Completed Breast Neoplasms NCT00051051
Endostar Combination With Chemotherapy and EGFR-TKI in Lung Cancer Rechallenging Treatment After Acquired Resistance. Unknown status Lung Cancer NCT02350361
A Window of Opportunity Trial of Afatinib In Early Stage Non-Small Cell Lung Cancer (NSCLC) Withdrawn Lung Cancer NCT01480141
A Study of LDK378 in Patients With Non-small Cell Lung Cancer Harboring ROS1 Rearrangement Recruiting Non-small Cell Lung Cancer Harboring ROS1 Rearrangement NCT03399487
Survival Outcomes and Tumor Molecular Profile Following Bicalutamide Neoadjuvant Therapy Completed Prostate Cancer NCT00418080
Phase 2 Study of AUY922 in NSCLC Patients With Exon 20 Insertion Mutations in EGFR Completed Non Small Cell Lung Cancer NCT01854034
A Phase II Trial of PF-00299804 in Patients With Metastatic or Recurrent Squamous Cell Carcinoma of Esophagus Completed Esophageal Squamous Cell Carcinoma NCT01608022
Clinical Trial to Evaluate Pharmacokinetics,Safety and Immunogenicity of Single Injection of CDP1 to Healthy Volunteers Compared to Erbitux Recruiting Healthy Volunteers NCT03881787
A Positron Emission Tomography (PET) Imaging Agent [18F]-ODS2004436 as a Marker of EGFR Mutation in Subjects With NSCLC Completed Carcinoma, Non-Small-Cell Lung NCT02847377
A Preliminary Clinical Study on the Pharmacokinetics and Safety of CDP1 in Patients With Advanced CRC or HNSCC Active, not recruiting Colorectal Cancer NCT03491709
Dasatinib and Osimertinib (AZD9291) in Advanced Non-Small Cell Lung Cancer With EGFR Mutations Active, not recruiting EGFR Gene Mutation|Nonsmall Cell Lung Cancer NCT02954523
Liver Function Test (LFT) Elevations in Cancer Patients and Users of Tyrosine Kinase Inhibitor (TKI) Drugs Completed Cancer NCT01098500
Phase II Trial of HM781-36B in Patients With Metastatic/Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) After Failure of or Unfit for Platinum-containing Therapy Recruiting HNSCC NCT02216916
Phase II Study of Afatinib as Third- or Further-line Treatment for Patients With Stage IV Bronchial Adenocarcinoma, Harboring Wild-type EGFR, Expressing the Neurotensin - Neurotensin Receptor Complex Withdrawn SMALL CELL LUNG CARCINOMA NCT02876081
A Retrospective Study of Biomarkers in Non-Small Cell Lung Cancer Unknown status Non Small Cell Lung Cancer NCT01100840
Metformin Plus TKI Use in Patients With Non-Small Cell Lung Carcinoma Unknown status Non-Small Cell Adenocarcinoma|Tyrosine Kinase Mutation|EGFR Gene Mutation NCT03071705
TAURAS - T790 AURA ScreenFailure SOC Registry Study Terminated Non Small Cell Lung Cancer NCT02405247
Low Dose Daily Erlotinib in Combination With High Dose Twice Weekly Erlotinib in Patients With EGFR-Mutant Lung Cancer Completed EGFR-Mutant Lung Cancer NCT01967095
Icotinib Combined With Whole Brain Radiotherapy in Treating Multiple Brain Metastases From Non-Small Cell Lung Cancer Completed Lung Cancer|Metastatic Cancer NCT01514877
Metformin in Stage IV Lung Adenocarcinoma Terminated Non-small Cell Lung Cancer NCT01997775
The Role of Brain Radiotherapy in Patients With Asymptomatic Brain Metastasis in the Era of Targeted Therapy for NSCLC Not yet recruiting Non Small Cell Lung Cancer|Brain Metastases NCT04193007
IMRT and Timing in Combination With EGFRTKI for Stage IV Non-small-cell Lung Cancer Not yet recruiting Non-Small Cell Lung Cancer|Nonsmall Cell Lung Cancer|Carcinoma, Non-Small-Cell Lung NCT03258671
Molecularly Target Therapy With FORFIRINOX in Advanced or Recurrent Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma Recruiting Cholangiocarcinoma of the Extrahepatic Bile Duct|Gallbladder Cancer NCT03768375
Retrospective Study in Non Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Completed NSCLC Non Small Cells Lung Cancer NCT02293733
Observational Study of Patients With Locally Advanced or Metastatic NSCLC (Non-Small Cell Lung Cancer) Terminated Carcinoma, Non-Small-Cell Lung NCT03053297
Intracranial Activity of AZD9291 (TAGRISSO) in Advanced EGFRm NSCLC Patients With Asymptomatic Brain Metastases Recruiting Lung Cancer NCT02736513
Genomic Based Assignment of Therapy in Advanced Urothelial Carcinoma Completed Urothelial Carcinoma|Bladder Cancer|Urinary Bladder Neoplasms NCT02788201
Epidermal Growth Factor Receptor and K-ras Mutations in Patients With Stage III Non-Small Cell Lung Cancer Completed Lung Cancer NCT00898924
N-of-1 Trial: Actionable Target Identification in Metastatic Cancer for Palliative Systemic Therapy Completed Metastatic Cancer NCT02142036
Treatment Patterns, Outcomes and Testing in EGFRm NSCLC Patients With EGFR TKI 1L Across Europe (REFLECT) Completed Lung Cancer NCT04031898
Vitamin C and Tyrosine Kinase Inhibitor in Lung Cancer Patients With Epidermal Growth Factor Receptor Mutations Recruiting Carcinoma, Non-Small-Cell Lung NCT03799094
Molecularly Target Therapy With GEMOX in Advanced or Recurrent Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma Recruiting Cholangiocarcinoma of the Extrahepatic Bile Duct|Gallbladder Cancer NCT02836847
Molecular Phenotype Changes and Personalized Treatment for CRPC Unknown status Hormone Refractory Prostate Cancer NCT02208583
Survey on the Treatment Reality of Patients With Epidermal Growth Factor Receptor (EGFR) Mutation-positive Non-small Cell Lung Cancer(NSCLC) Completed Carcinoma, Non-Small-Cell Lung NCT02475720
Low-frequency Rotating Magnetic System Combined With Systemic Anti-tumor Therapy for Advanced Lung Cancer Recruiting Lung Neoplasms NCT02701231
Radical Treatment of Synchronous Oligometastatic Non-Small Cell Lung Carcinoma Unknown status Carcinoma, Non-Small-Cell Lung|Synchronous Neoplasms NCT02805530
Evaluating Preventive Therapy With Oint Threolone, Synthomycine or Aqua Cream, for EGFR'I Induced Acneiform Rash Completed Acneiform Rash NCT01256437
A Study of DS-2248, in Subjects With Advanced Solid Tumors Terminated Solid Tumors|Non-small Cell Lung Carcinoma NCT01288430
PD-1 Immune Checkpoint Inhibitors and Immune-Related Adverse Events: a Cohort Study Not yet recruiting Carcinoma, Non-Small-Cell Lung|Immune-Related Adverse Events NCT04115410
High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia Recruiting Acute Leukemia of Ambiguous Lineage|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia|Refractory Adult Acute Lymphoblastic Leukemia|Refractory Childhood Acute Lymphoblastic Leukemia NCT02551718
Molecular Profiling and Matched Targeted Therapy for Patients With Metastatic Melanoma Not yet recruiting Melanoma NCT02645149

Visualization

References

Publication DOI Pubmed PMCID
Dihydroartemisinin and gefitinib synergistically inhibit NSCLC cell growth and promote apoptosis via the Akt/mTOR/STAT3 pathway. Molecular medicine reports Hong Jin, Ai-Ying Jiang, Han Wang, Yong Cao, Yan Wu, Xiao-Feng Jiang, 16, 3, None, 2017-07-14, 10.3892/mmr.2017.6989 10.3892/mmr.2017.6989 28713965 28713965

Filter data

Compound Gefitinib
Experiment types CCK8 assay, Flow cytometry- annexin V binding and propidium iodide staining, Invasion assay , TUNEL, Western Blot
Concentrations 10.00
Cell lines NCI‑H1975
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3
Other AKT, Bax, Bcl-2, Cdk1, Cyclin B1, mTOR, p-AKT, p-mTOR, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Gefitinib CCK8 assay Inlfuence on cell viability in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib CCK8 assay Inlfuence on cell viability 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib TUNEL Inlfuence on cell viability in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib TUNEL Inlfuence on cell viability 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Flow cytometry- annexin V binding and propidium iodide staining Inlfuence on cell cycle in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Flow cytometry- annexin V binding and propidium iodide staining Inlfuence on cell cycle 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Inlfuence on cell cycle in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Inlfuence on cell cycle 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Inlfuence on cell cycle in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Inlfuence on cell cycle 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Inlfuence on cell cycle in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Inlfuence on cell cycle 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Invasion assay Influence on cell motility 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Invasion assay Influence on cell motility in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity 10.00 µM NCI‑H1975 Homo sapiens STAT3
Gefitinib Western Blot Influence on protein activity in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens STAT3
Gefitinib Western Blot Influence on protein activity 10.00 µM NCI‑H1975 Homo sapiens p-STAT3
Gefitinib Western Blot Influence on protein activity in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens p-STAT3
Gefitinib Western Blot Influence on protein activity 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity 10.00 µM NCI‑H1975 Homo sapiens
Gefitinib Western Blot Influence on protein activity in presence of DHA 10.00 µM NCI‑H1975 Homo sapiens