E738

Name Value
Weight 381.388 g/mol
Zinc ID ZINC001772619165
Smiles COc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\OC[C@@H](O)CO)C(=O)N2
Molecular formula C20H19N3O5
Mode of inhibition SRC, JAK, STAT inhibitor
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Molecular oncology Sangkil Nam, Wei Wen, Anne Schroeder, Andreas Herrmann, Hua Yu, Xinlai Cheng, Karl-Heinz Merz, Gerhard Eisenbrand, Hongzhi Li, Yate-Ching Yuan, Richard Jove, 7, 3, None, 2012-11-16, 10.1016/j.molonc.2012.10.013 10.1016/j.molonc.2012.10.013 23206899 PMC3968804

Filter data

Compound E738
Experiment types Flow cytometry , Fluorescent staining, Kinase activity assay , MTS, Western Blot
Concentrations 0.10, 0.50, 0.70, 1.00, 10.00, 10.40, 2.50, 5.00, 74.10
Cell lines AcPC1, BxPC3, MIA-PaCa2, Panc-1
Organisms Homo sapiens
Animal models
STAT proteins STAT3, STAT3-YFP, p-STAT3 (Tyr705)
Other Actin, Cleaved PARP, JAK1, JAK2, Mcl-1, PARP, Src, Survivin, TYK2, p-JAK2 (Tyr1007/1008), p-Src (Tyr419)

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
E738 Kinase activity assay Influence on kinase activity 10.40 nM Homo sapiens
E738 Kinase activity assay Influence on kinase activity 74.10 nM Homo sapiens
E738 Kinase activity assay Influence on kinase activity 0.70 nM Homo sapiens
E738 MTS Influence on cell viability 0.10 µM Panc-1 Homo sapiens
E738 MTS Influence on cell viability 0.50 µM Panc-1 Homo sapiens
E738 MTS Influence on cell viability 2.50 µM Panc-1 Homo sapiens
E738 MTS Influence on cell viability 5.00 µM Panc-1 Homo sapiens
E738 MTS Influence on cell viability 10.00 µM Panc-1 Homo sapiens
E738 MTS Influence on cell viability 0.10 µM MIA-PaCa2 Homo sapiens
E738 MTS Influence on cell viability 0.50 µM MIA-PaCa2 Homo sapiens
E738 MTS Influence on cell viability 2.50 µM MIA-PaCa2 Homo sapiens
E738 MTS Influence on cell viability 5.00 µM MIA-PaCa2 Homo sapiens
E738 MTS Influence on cell viability 10.00 µM MIA-PaCa2 Homo sapiens
E738 MTS Influence on cell viability 0.10 µM BxPC3 Homo sapiens
E738 MTS Influence on cell viability 0.50 µM BxPC3 Homo sapiens
E738 MTS Influence on cell viability 2.50 µM BxPC3 Homo sapiens
E738 MTS Influence on cell viability 5.00 µM BxPC3 Homo sapiens
E738 MTS Influence on cell viability 10.00 µM BxPC3 Homo sapiens
E738 MTS Influence on cell viability 0.10 µM AcPC1 Homo sapiens
E738 MTS Influence on cell viability 0.50 µM AcPC1 Homo sapiens
E738 MTS Influence on cell viability 2.50 µM AcPC1 Homo sapiens
E738 MTS Influence on cell viability 5.00 µM AcPC1 Homo sapiens
E738 MTS Influence on cell viability 10.00 µM AcPC1 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM BxPC3 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM AcPC1 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM BxPC3 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM AcPC1 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM BxPC3 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM AcPC1 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM BxPC3 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM AcPC1 Homo sapiens
E738 Western Blot Influence on protein activity 5.00 µM Panc-1 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 5.00 µM MIA-PaCa2 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 5.00 µM BxPC3 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 5.00 µM AcPC1 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 5.00 µM Panc-1 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 5.00 µM MIA-PaCa2 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 5.00 µM BxPC3 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 5.00 µM AcPC1 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 0.10 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 0.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 1.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 2.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 0.10 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 0.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 1.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 2.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 0.10 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 0.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 1.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 2.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 0.10 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 0.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 1.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 2.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 0.10 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 0.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 1.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 2.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 0.10 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 0.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 1.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 2.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 0.10 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 0.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 1.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 2.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on protein activity 0.10 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 0.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 1.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 2.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on protein activity 0.10 µM Panc-1 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 0.50 µM Panc-1 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 1.00 µM Panc-1 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 2.50 µM Panc-1 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 0.10 µM MIA-PaCa2 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 0.50 µM MIA-PaCa2 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 1.00 µM MIA-PaCa2 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 2.50 µM MIA-PaCa2 Homo sapiens p-STAT3 (Tyr705)
E738 Western Blot Influence on protein activity 0.10 µM Panc-1 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 0.50 µM Panc-1 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 1.00 µM Panc-1 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 2.50 µM Panc-1 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 0.10 µM MIA-PaCa2 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 0.50 µM MIA-PaCa2 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 1.00 µM MIA-PaCa2 Homo sapiens STAT3
E738 Western Blot Influence on protein activity 2.50 µM MIA-PaCa2 Homo sapiens STAT3
E738 Fluorescent staining Influence on STAT3 nuclear translocation 0.10 µM Panc-1 Homo sapiens STAT3-YFP
E738 Fluorescent staining Influence on STAT3 nuclear translocation 0.50 µM Panc-1 Homo sapiens STAT3-YFP
E738 Fluorescent staining Influence on STAT3 nuclear translocation 1.00 µM Panc-1 Homo sapiens STAT3-YFP
E738 Fluorescent staining Influence on STAT3 nuclear translocation 2.50 µM Panc-1 Homo sapiens STAT3-YFP
E738 Fluorescent staining Influence on STAT3 nuclear translocation 5.00 µM Panc-1 Homo sapiens STAT3-YFP
E738 Western Blot Influence on apoptotic proteins 0.10 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.10 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.10 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.10 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.10 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.10 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.10 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.10 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.10 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM MIA-PaCa2 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.10 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 0.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 1.00 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 2.50 µM Panc-1 Homo sapiens
E738 Western Blot Influence on apoptotic proteins 5.00 µM Panc-1 Homo sapiens
E738 Flow cytometry Influence on apoptosis 0.10 µM MIA-PaCa2 Homo sapiens
E738 Flow cytometry Influence on apoptosis 0.50 µM MIA-PaCa2 Homo sapiens
E738 Flow cytometry Influence on apoptosis 1.00 µM MIA-PaCa2 Homo sapiens
E738 Flow cytometry Influence on apoptosis 2.50 µM MIA-PaCa2 Homo sapiens
E738 Flow cytometry Influence on apoptosis 5.00 µM MIA-PaCa2 Homo sapiens